Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Keys , J. T. Anderson (1955)
Weight Gain from Simple OvereatingMetabolism, 4
G. B. Forbes , A. F. Reed, J. Bonderant (1956)
Changes in Body Chloride During GrowthPediatrics, 17
D. C. Darrow , E. L. Pratt, J. Flett, H. H. Gamble (1949)
Disturbances in Water Electrolytes in Infantile DiarrheaPediatrics, 3
B. Friis‐Hansen (1957)
Changes in Body Water Compartments during GrowthActa Pædiatrica, 46
M. McDowell, A. Wolf, A. Steer (1955)
Osmotic volumes of distribution; idiogenic changes in osmotic pressure associated with administration of hypertonic solutions.The American journal of physiology, 180 3
D. Darrow, H. Yannet (1935)
THE CHANGES IN THE DISTRIBUTION OF BODY WATER ACCOMPANYING INCREASE AND DECREASE IN EXTRACELLULAR ELECTROLYTE.The Journal of clinical investigation, 14 2
R. Cooke, W. Segar, C. Reed, D. Etzwiler, M. Vita, S. Brusilow, D. Darrow (1953)
The role of potassium in the prevention of alkalosis.The American journal of medicine, 17 2
G. Forbes, A. Reid, J. Bondurant, J. Etheridge (1956)
Changes in total body chloride during growth.Pediatrics, 17 3
C. Moulton (1923)
AGE AND CHEMICAL DEVELOPMENT IN MAMMALSJournal of Biological Chemistry, 57
J. D. Crawford , M. E. Terry (1950)
Simplification of Drug Dosage by Application of Surface Area PrinciplePediatrics, 5
J. Laragh (1954)
The effect of potassium chloride on hyponatremia.The Journal of clinical investigation, 33 5
S. Frenk, J. Metcoff, F. Gómez, R. Ramos-Galván, J. Cravioto, I. Antonowicz (1957)
Intracellular composition and hemostatic mechanisms in severe chronic infantile malnutrition. II. Composition of tissues.Pediatrics, 20 1 Part 1
J. Laragh, N. Capeci (1955)
Effect of administration of potassium chloride on serum sodium and potassium concentration.The American journal of physiology, 180 3
L. Finberg (1959)
Pathogenesis of lesions in the nervous system in hypernatremic states. I. Clinical ovservations of infants.Pediatrics, 23 1 Pt 1
B. Friis-Hansen (1957)
Changes in Body Water Compartments During GrowthActa Paediat., 46
H. Yannet, D. Darrow (1940)
THE EFFECT OF DEPLETION OF EXTRACELLULAR ELECTROLYTES ON THE CHEMICAL COMPOSITION OF SKELETAL MUSCLE, LIVER, AND CARDIAC MUSCLEJournal of Biological Chemistry, 134
D. Cheek (1954)
Observations on total body chloride in children.Pediatrics, 14 1
E. F. Du Bois (1939)
Heat Loss from the Human Body: Harvey LectureBull. New York Acad. Med., 15
L. Finberg (1959)
Pathogensis of Lesions in the Nervous System in Hypernatremic StatesPediatrics, 23
W. H. Bergstrom (1959)
Total Body Water and Normal Electrolyte CompositionPediat. Clin. North America, 6
Roy Swan, Robert Pitts, H. Madisso (1955)
Neutralization of infused acid by nephrectomized dogs.The Journal of clinical investigation, 34 2
S. J. Frenk , J. Metcoff, F. Gómez, R. Ramos-Galván, J. Cravioto (1957)
Intracellular Composition and Homeostatic Mechanisms in Severe Infantile MalnutritionPediatrics, 20
W. Oliver, B. Graham, J. Wilson (1958)
Lack of scientific validity of body surface as basis for parenteral fluid dosage.Journal of the American Medical Association, 167 10
Abstract For some time I have felt that doctors have created unnecessary confusion in the rules intended to take account of the different body sizes of infants, children, and adults. The difficulty arises largely from failure to utilize available knowledge of physiological relationships. Doctors know that total metabolism is considerably greater per kilogram of body weight in infants than in adults. Consequently, total metabolism rather than weight is the appropriate measure of those functions dependent on rate of metabolic turnover. Body weight is the measure of the mass of water, electrolyte, and protoplasm in which metabolic changes are taking place. In other words, body size has two dimensions. Attempts to bypass either of these dimensions fails to bring into view the relevant physiological relationships and establishes no adequate frame of reference which permits logical analysis. However, using the correct dimensions, present knowledge permits the same physiological principles to be applied to References 1. Du Bois, E. F.: Heat Loss from the Human Body: Harvey Lecture , Bull. New York Acad. Med. 15:143, 1939. 2. Crawford, J. D.; Terry, M. E., and Rourke, G. M.: Simplification of Drug Dosage by Application of Surface Area Principle , Pediatrics 5:783, 1950. 3. Oliver, W. J.; Graham, B. D., and Wilson, J. L.: Lack of Scientific Validity of Body Sur face as Basis for Parenteral Fluid Therapy . J.A.M.A. 167:1211, 1958.Crossref 4. Moulton, C. R.: Age and Chemical Development of Mammals , J. Biol. Chem. 57:79, 1923. 5. Keys, A.; Anderson, J. T., and Brozek, J.: Weight Gain from Simple Overeating , Metabolism 4:427, 1955. 6. Frenk, S. J.; Metcoff, J.; Gómez, F.; Ramos-Galván, R.; Cravioto, J., and Antonowicz, I.: Intracellular Composition and Homeostatic Mechanisms in Severe Infantile Malnutrition , Pediatrics 20:105, 1957. 7. Cheek, D. B.: Observations on Total Body Chloride in Children , Pediatrics 14:5, 1954. 8. Forbes, G. B.; Reed, A. F.; Bonderant, J., and Etheridge, J.: Changes in Body Chloride During Growth , Pediatrics 17:334, 1956. 9. Friis-Hansen, B.: Changes in Body Water Compartments During Growth , Acta Paediat. , Vol. 46, (Supp. 110) , 1957. 10. Darrow, D. C., and Yannet, H.: The Changes in Distribution of Body Water Accompanying Increase in Decrease of Extracellular Electrolyte , J. Clin. Invest. 14:266, 1935.Crossref 11. Yannet, H., and Darrow, D. C.: The Effect of Depletion of Extracellular Electrolytes on the Composition of Skeletal Muscle, Liver, and Cardiac Muscle , J. Biol. Chem. 134:721, 1940. 12. McDowell, R.; Wolf, A. V., and Steere, A.: Osmotic Volumes of Distribution: Idiogenic Changes in Osmotic Pressure Associated with Administration of Hypertonic Solutions , Am. J. Physiol. 180:545, 1955. 13. Laragh, J. H., and Capeci, N. E.: Effect of Administration of Potassium Chloride on Serum Sodium and Potassium Concentration , Am. J. Physiol. 180:539, 1955. 14. Laragh, J. H.: Effect of Potassium Chloride on Hyponatremia , J. Clin. Invest. 33:807, 1954.Crossref 15. Darrow, D. C.; Pratt, E. L.; Flett, J., Jr.; Gamble, H. H., and Wiese, H. F.: Disturbances in Water Electrolytes in Infantile Diarrhea , Pediatrics 3:179, 1949. 16. Finberg, L.: Pathogensis of Lesions in the Nervous System in Hypernatremic States , Pediatrics 23:40, 1959. 17. Swan, R. C., and Pitts, R. F.: Neutralization of Infused Acid by Nephrectomized Dogs , J. Clin. Invest. 34:205, 1955.Crossref 18. Bergstrom, W. H.: Total Body Water and Normal Electrolyte Composition , Pediat. Clin. North America 6:5, 1959. 19. Cooke, R. E.; Segar, W. E.; Reed, C.; Etzwiler, D. D.; Vita, M.; Brusilow, S., and Darrow, D. C.: The Role of Potassium in the Prevention of Alkalosis , Am. J. Med. 17:180, 1954.Crossref
A.M.A. Journal of Diseases of Children – American Medical Association
Published: Oct 1, 1959
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.