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The Significance of a Positive L. E. Phenomenon

The Significance of a Positive L. E. Phenomenon Abstract Since the interesting discovery of the L. E. phenomenon by Hargraves and his co-workers,1 the diagnosis of systemic lupus erythematosus has been vastly facilitated and has been made in a number of hitherto obscure conditions. Moreover, certain cases of rheumatic and allied diseases have presented this blood picture, raising the question of whether or not this group of diseases is another manifestation of the etiologic agent which causes lupus erythematosus. Furthermore, the phenomenon has been reported in patients with drug allergies, and it has been suggested that the increase in the number of patients with lupus erythematous is due not only to more acute diagnosis and the rising interest in the disease, but also to the indiscriminate use of the sulfonamides and the antibiotics, especially penicillin. During the past year, we have examined a fairly large series of bloods from patients whose diseases References 1. References 11 to 14. 2. Saunders, J. C. (Ciba Pharmaceutical Products, Inc.): Personal communication to the authors. 3. Hargraves, M. M.: Personal communication to the authors. 4. Hagemann, P. O.: Personal communication to the authors. 5. References 29 and 30. 6. Hargraves, M. M.; Richmond, H., and Morton, R.: Presentation of Two Bone Marrow Elements: The "Tart" Cell and the "L. E." Cell , Proc. Staff Meet., Mayo Clin. 23:25, 1948. 7. Dubois, E. L.: Acquired Hemolytic Anemia as the Presenting Symptom of Lupus Erythematosus Disseminatus , Am. J. Med. 12:197, 1952.Crossref 8. Zimmer, F. E., and Hargraves, M. M.: The Effect of Blood Coagulation on L. E. Cell Formation , Proc. Staff Meet., Mayo Clin. 27:424, 1952. 9. Magath, T. B., and Winkle, V.: Technic for Demonstrating "L. E." (Lupus Erythematosus) Cells in Blood , Am. J. Clin. Path. 22:586, 1952. 10. Barnes, S. S.; Moffatt, T. W., and Weiss, R. S.: Demonstration of the L. E. Cell in the Absence of Anticoagulant , J. Invest. Dermat. 14: 397, 1950. 11. Walsh, J. R., and Zimmerman, H. J.: Demonstration of the L. E. Phenomenon in Patients with Penicillin Hypersensitivity , Blood 8:65, 1953. 12. Paull, A. M.: Occurrence of the L. E. Phenomenon in a Patient with a Severe Penicillin Reaction , New England J. Med. 252:128, 1955.Crossref 13. Brown, E. A.: Drug Allergy , Quart. Rev. Allergy 7:51, 1953. 14. Lincoln, M., and Ricker, W. A.: A Case of Periarteritis Nodosa with L. E. Cells: Apparent Complete Remission with Cortisone Therapy , Ann. Int. Med. 41:639, 1954.Crossref 15. Stich, M. H.; Feldman, F., and Morrison, M.: Pre-L. E. Cell: A Stage in Development of the L. E. Phenomenon , A. M. A. Arch. Dermat. & Syph. 65:581, 1952. 16. Dustan, H. P.; Taylor, R. D.; Corcoran, A. C., and Page, I. H.: Rheumatic and Febrile Syndrome During Prolonged Hydralazine Treatment , J. A. M. A. 154:23, 1954. 17. Perry, H. M., and Schroeder, H. A.: Syndrome Simulating Collagen Disease Caused by Hydralazine (Apresoline) , J. A. M. A. 154:670, 1954. 18. Reinhardt, D. J., and Waldron, J. M.: Lupus Erythematosus-like Syndrome Complicating Hydralazine (Apresoline) Therapy , J. A. M. A. 155: 1491, 1954. 19. Shackman, N. H.; Swiller, A. I., and Morrison, M.: Syndrome Simulating Acute Disseminated Lupus Erythematosus: Appearance After Hydralazine (Apresoline) Therapy , J. A. M. A. 155:1492, 1954. 20. Turner, L. W., and Lansbury, J.: Low Diastolic Pressure as a Clinical Feature of Rheumatoid Arthritis and its Possible Etiologic Significance , Am. J. Med. Sc. 227:503, 1954. 21. Meyler, L.: Phagocytosis in Drug Allergy , Acta med. scandinav. 150:33, 1954. 22. Hargraves, M. M.: Systemic Lupus Erythematosus and L. E. Cell Phenomenon , Postgrad. Med. 16:164, 1954. 23. Holman, S.: The Lupus Erythematosus Cell Inclusion Phenomenon , J. Clin. Path. 4:290, 1951. 24. Rasponi, L.: Observations on the L. E. Phenomenon in Different Types of Lupus Erythematosus , Arch. ital. dermat. sif. 26:121, 1954. 25. Haserick, J. R.: Simulation of the Lupus Erythematosus Phenomenon by Materials of Fungal Origin , J. Invest. Dermat. 16:211, 1951. 26. Soffer, L. J.; Levitt, M. F., and Baehr, G.: Use of Cortisone and Adrenocorticotropic Hormone in Acute Disseminated Lupus Erythematosus , Arch. Int. Med. 86:558, 1950.Crossref 27. Gausewitz, P. L.; Jones, F. S., and Worley, G.: Fatal Generalized Moniliasis , Am. J. Clin. Path. 21:41, 1951. 28. Hauser, W.: Beobachtung des L. E.-ZellenPhänomens bei einer Kranken mit Senear-Usher Syndrom , Hautartz 3:281, 1952. 29. Berman, L.; Axelrod, A. R.; Goodman, H. L., and McClaughry, R. I.: So-Called "Lupus Erythematosus Inclusion Phenomenon" of Bone Marrow and Blood , Am. J. Clin. Path. 20:403, 1950. 30. Mongomery, H., and McCreight, W. G.: Disseminate Lupus Erythematosus , Arch. Dermat. & Syph. 60:356, 1949. 31. Lee, S. L.; Michael, S. R., and Vural, I. L.: L. E. (Lupus Erythematosus) Cell , Am. J. Med. 10:446, 1951. 32. Fisher, G. S., and Moyer, J. B.: Hematologic Phenomena as a Test for Acute Disseminated Lupus Erythematosus , Grace Hosp. Bull. 28:3, 1950. 33. Miescher, P.: Immunophagocytose des éléments cellulaires dans le sang , J. suisse méd. 9:216, 1953. 34. Marshall, J.; Zoutendyk, A., and Gear, J.: Serum Auto-Antibodies in Diseases of the Skin , South African M. J. 25:764, 1951. 35. Zoutendyk, A., and Gear, J.: Lupus Erythematosus—An Auto-Antibody Disease? Brit. M. J. 2:1175, 1950. 36. Gold, S.: Role of Sulphonamides and Penicillin in Pathogenesis of Systemic Lupus Erythematosus , Lancet 1:268, 1951. 37. Pisciotta, A. V.; Giliberti, J. J.; Greenwalt, T. J., and Engstrom, W. W.: Acute Hemolytic Anemia in Disseminate Lupus Erythematosus , Am. J. Clin. Path. 21:1139, 1951. 38. Engman, M. F., Jr.: Early Acute Lupus Erythematosus , Arch. Dermat. & Syph. 35:685, 1937. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Significance of a Positive L. E. Phenomenon

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1955.03730320001001
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Abstract

Abstract Since the interesting discovery of the L. E. phenomenon by Hargraves and his co-workers,1 the diagnosis of systemic lupus erythematosus has been vastly facilitated and has been made in a number of hitherto obscure conditions. Moreover, certain cases of rheumatic and allied diseases have presented this blood picture, raising the question of whether or not this group of diseases is another manifestation of the etiologic agent which causes lupus erythematosus. Furthermore, the phenomenon has been reported in patients with drug allergies, and it has been suggested that the increase in the number of patients with lupus erythematous is due not only to more acute diagnosis and the rising interest in the disease, but also to the indiscriminate use of the sulfonamides and the antibiotics, especially penicillin. During the past year, we have examined a fairly large series of bloods from patients whose diseases References 1. References 11 to 14. 2. Saunders, J. C. (Ciba Pharmaceutical Products, Inc.): Personal communication to the authors. 3. Hargraves, M. M.: Personal communication to the authors. 4. Hagemann, P. O.: Personal communication to the authors. 5. References 29 and 30. 6. Hargraves, M. M.; Richmond, H., and Morton, R.: Presentation of Two Bone Marrow Elements: The "Tart" Cell and the "L. E." Cell , Proc. Staff Meet., Mayo Clin. 23:25, 1948. 7. Dubois, E. L.: Acquired Hemolytic Anemia as the Presenting Symptom of Lupus Erythematosus Disseminatus , Am. J. Med. 12:197, 1952.Crossref 8. Zimmer, F. E., and Hargraves, M. M.: The Effect of Blood Coagulation on L. E. Cell Formation , Proc. Staff Meet., Mayo Clin. 27:424, 1952. 9. Magath, T. B., and Winkle, V.: Technic for Demonstrating "L. E." (Lupus Erythematosus) Cells in Blood , Am. J. Clin. Path. 22:586, 1952. 10. Barnes, S. S.; Moffatt, T. W., and Weiss, R. S.: Demonstration of the L. E. Cell in the Absence of Anticoagulant , J. Invest. Dermat. 14: 397, 1950. 11. Walsh, J. R., and Zimmerman, H. J.: Demonstration of the L. E. Phenomenon in Patients with Penicillin Hypersensitivity , Blood 8:65, 1953. 12. Paull, A. M.: Occurrence of the L. E. Phenomenon in a Patient with a Severe Penicillin Reaction , New England J. Med. 252:128, 1955.Crossref 13. Brown, E. A.: Drug Allergy , Quart. Rev. Allergy 7:51, 1953. 14. Lincoln, M., and Ricker, W. A.: A Case of Periarteritis Nodosa with L. E. Cells: Apparent Complete Remission with Cortisone Therapy , Ann. Int. Med. 41:639, 1954.Crossref 15. Stich, M. H.; Feldman, F., and Morrison, M.: Pre-L. E. Cell: A Stage in Development of the L. E. Phenomenon , A. M. A. Arch. Dermat. & Syph. 65:581, 1952. 16. Dustan, H. P.; Taylor, R. D.; Corcoran, A. C., and Page, I. H.: Rheumatic and Febrile Syndrome During Prolonged Hydralazine Treatment , J. A. M. A. 154:23, 1954. 17. Perry, H. M., and Schroeder, H. A.: Syndrome Simulating Collagen Disease Caused by Hydralazine (Apresoline) , J. A. M. A. 154:670, 1954. 18. Reinhardt, D. J., and Waldron, J. M.: Lupus Erythematosus-like Syndrome Complicating Hydralazine (Apresoline) Therapy , J. A. M. A. 155: 1491, 1954. 19. Shackman, N. H.; Swiller, A. I., and Morrison, M.: Syndrome Simulating Acute Disseminated Lupus Erythematosus: Appearance After Hydralazine (Apresoline) Therapy , J. A. M. A. 155:1492, 1954. 20. Turner, L. W., and Lansbury, J.: Low Diastolic Pressure as a Clinical Feature of Rheumatoid Arthritis and its Possible Etiologic Significance , Am. J. Med. Sc. 227:503, 1954. 21. Meyler, L.: Phagocytosis in Drug Allergy , Acta med. scandinav. 150:33, 1954. 22. Hargraves, M. M.: Systemic Lupus Erythematosus and L. E. Cell Phenomenon , Postgrad. Med. 16:164, 1954. 23. Holman, S.: The Lupus Erythematosus Cell Inclusion Phenomenon , J. Clin. Path. 4:290, 1951. 24. Rasponi, L.: Observations on the L. E. Phenomenon in Different Types of Lupus Erythematosus , Arch. ital. dermat. sif. 26:121, 1954. 25. Haserick, J. R.: Simulation of the Lupus Erythematosus Phenomenon by Materials of Fungal Origin , J. Invest. Dermat. 16:211, 1951. 26. Soffer, L. J.; Levitt, M. F., and Baehr, G.: Use of Cortisone and Adrenocorticotropic Hormone in Acute Disseminated Lupus Erythematosus , Arch. Int. Med. 86:558, 1950.Crossref 27. Gausewitz, P. L.; Jones, F. S., and Worley, G.: Fatal Generalized Moniliasis , Am. J. Clin. Path. 21:41, 1951. 28. Hauser, W.: Beobachtung des L. E.-ZellenPhänomens bei einer Kranken mit Senear-Usher Syndrom , Hautartz 3:281, 1952. 29. Berman, L.; Axelrod, A. R.; Goodman, H. L., and McClaughry, R. I.: So-Called "Lupus Erythematosus Inclusion Phenomenon" of Bone Marrow and Blood , Am. J. Clin. Path. 20:403, 1950. 30. Mongomery, H., and McCreight, W. G.: Disseminate Lupus Erythematosus , Arch. Dermat. & Syph. 60:356, 1949. 31. Lee, S. L.; Michael, S. R., and Vural, I. L.: L. E. (Lupus Erythematosus) Cell , Am. J. Med. 10:446, 1951. 32. Fisher, G. S., and Moyer, J. B.: Hematologic Phenomena as a Test for Acute Disseminated Lupus Erythematosus , Grace Hosp. Bull. 28:3, 1950. 33. Miescher, P.: Immunophagocytose des éléments cellulaires dans le sang , J. suisse méd. 9:216, 1953. 34. Marshall, J.; Zoutendyk, A., and Gear, J.: Serum Auto-Antibodies in Diseases of the Skin , South African M. J. 25:764, 1951. 35. Zoutendyk, A., and Gear, J.: Lupus Erythematosus—An Auto-Antibody Disease? Brit. M. J. 2:1175, 1950. 36. Gold, S.: Role of Sulphonamides and Penicillin in Pathogenesis of Systemic Lupus Erythematosus , Lancet 1:268, 1951. 37. Pisciotta, A. V.; Giliberti, J. J.; Greenwalt, T. J., and Engstrom, W. W.: Acute Hemolytic Anemia in Disseminate Lupus Erythematosus , Am. J. Clin. Path. 21:1139, 1951. 38. Engman, M. F., Jr.: Early Acute Lupus Erythematosus , Arch. Dermat. & Syph. 35:685, 1937.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1955

References