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J. Toomey, Myron August (1929)
STUDIES IN SCARLET FEVER: VII. BLANCHING WITH PLACENTAL SERUMJAMA Pediatrics, 38
W. Park, R. Spiegel (1925)
Complexity of the Scarlet Fever Toxin and AntitoxinThe Journal of Immunology
A. Dochez (1924)
THE SIGNIFICANCE OF STREPTOCOCCUS HEMOLYTICUS IN SCARLET FEVER: AND THE PREPARATION OF A SPECIFIC ANTISCARLATINAL SERUM BY IMMUNIZATION OF THE HORSE TO STREPTOCOCCUS HEMOLYTICUS-SCARLATINAEJAMA, 82
W. Park (1925)
SCARLET FEVER: ETIOLOGY, PREVENTION BY IMMUNIZATION, AND ANTITOXIC TREATMENTJAMA, 85
M. Kirkbride, M. Wheeler (1924)
Comparison of reactions in individuals to toxins prepared from three strains of scarlet fever streptococci.Proceedings of the Society for Experimental Biology and Medicine, 22
H. Singer, B. Kaplan (1926)
STREPTOCOCCUS ERYSIPELATIS TOXIN AND ANTITOXINJAMA, 87
J. Neumann (1920)
Das Auslöschphänomen, ein neues brauchbares Hilfsmittel bei der Diagnose des ScharlachsDeutsche Medizinische Wochenschrift, 46
W. Mair (1923)
AN IMMUNITY REACTION IN SCARLET FEVER.The Lancet, 202
J. Cooke (1927)
Skin Reactions to Scarlatinal Streptococcus Filtrate in New-Born Infants and Their Mothers.Proceedings of the Society for Experimental Biology and Medicine, 24
J. Toomey (1928)
STUDIES IN SCARLET FEVER: SKIN BLANCHING BY COMMERCIAL ANTITOXINSJAMA Pediatrics, 35
In 1918, Schultz and Charlton1 first reported that the intracutaneous injection of from 0.5 to 1 cc. of normal or scarlet fever convalescent serum would blanch the rash of scarlet fever at the site of injection. They also showed that the blanching substance was present in serum taken after the fourteenth day of scarlet fever, but that serum taken earlier in the disease did not have blanching power. Plain horse serum or diphtheria antitoxin failed to blanch the rash. Schultz and Charlton also made injections of a dilute solution of epinephrine hydrochloride intracutaneously, and found that the rash blanched within a few minutes. This blanching lasted five or six hours. In contrast, the reaction produced by scarlet fever convalescent serum appeared only after five or six hours and lasted several days. Schultz and Charlton expressed the belief that human serum contained some vasoconstricting factor which counteracted the vasodilating effect
American journal of diseases of children – American Medical Association
Published: Dec 1, 1933
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