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The Role of Microcirculatory Dysfunction in the Pathophysiology and Treatment of Venous Leg Ulcers

The Role of Microcirculatory Dysfunction in the Pathophysiology and Treatment of Venous Leg Ulcers Letters 4. Neven B, Pérot P, Bruneau J, et al. Cutaneous and visceral chronic Streptococcus pneumoniae, Haemophilus influenzae, and tetanus granulomatous disease triggered by a rubella virus vaccine strain in children toxoid despite the patient receiving these vaccines on schedule. with primary immunodeficiencies. Clin Infect Dis. 2017;64(1):83-86. doi:10. Isolatedcutaneousgranulomasmaybeapreviouslyunknownfea- 1093/cid/ciw675 ture of her particular NOD mutation variant, or perhaps further 5. Caso F, Galozzi P, Costa L, Sfriso P, Cantarini L, Punzi L. Autoinflammatory immunology evaluation may yield another explanation. granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn’s disease. RMD Open. 2015;1(1):e000097. doi:10.1136/rmdopen-2015-000097 Discussion | These 2 cases add to the growing number of reports 6. Lo Schiavo A, Ruocco E, Russo T, Brancaccio G. Locus minoris resistentiae: regarding VDRV in association with granulomas in patients with An old but still valid way of thinking in medicine. Clin Dermatol. 2014;32(5): immunesystemdefects.ThefindingofVDRVingranulomasraises 553-556. doi:10.1016/j.clindermatol.2014.04.001 the question of whether rubella vaccine is an antigenic trigger or a bystander. The cases described in the literature report the lo- calizationofVDRVinaffectedskin,itsabsenceinnormalskin,and COMMENT & RESPONSE itsabilitytopersistinanti-inflammatoryM2macrophages,aswell as keratinocytes, while accumulating mutations. All reports sug- The Role of Microcirculatory Dysfunction gestacausalrelationshipbetween rubella viruspersistence inthe in the Pathophysiology and Treatment 1-4 skinandgranulomadevelopment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

The Role of Microcirculatory Dysfunction in the Pathophysiology and Treatment of Venous Leg Ulcers

JAMA Dermatology , Volume 155 (7) – Jul 15, 2019

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Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2019.0591
Publisher site
See Article on Publisher Site

Abstract

Letters 4. Neven B, Pérot P, Bruneau J, et al. Cutaneous and visceral chronic Streptococcus pneumoniae, Haemophilus influenzae, and tetanus granulomatous disease triggered by a rubella virus vaccine strain in children toxoid despite the patient receiving these vaccines on schedule. with primary immunodeficiencies. Clin Infect Dis. 2017;64(1):83-86. doi:10. Isolatedcutaneousgranulomasmaybeapreviouslyunknownfea- 1093/cid/ciw675 ture of her particular NOD mutation variant, or perhaps further 5. Caso F, Galozzi P, Costa L, Sfriso P, Cantarini L, Punzi L. Autoinflammatory immunology evaluation may yield another explanation. granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn’s disease. RMD Open. 2015;1(1):e000097. doi:10.1136/rmdopen-2015-000097 Discussion | These 2 cases add to the growing number of reports 6. Lo Schiavo A, Ruocco E, Russo T, Brancaccio G. Locus minoris resistentiae: regarding VDRV in association with granulomas in patients with An old but still valid way of thinking in medicine. Clin Dermatol. 2014;32(5): immunesystemdefects.ThefindingofVDRVingranulomasraises 553-556. doi:10.1016/j.clindermatol.2014.04.001 the question of whether rubella vaccine is an antigenic trigger or a bystander. The cases described in the literature report the lo- calizationofVDRVinaffectedskin,itsabsenceinnormalskin,and COMMENT & RESPONSE itsabilitytopersistinanti-inflammatoryM2macrophages,aswell as keratinocytes, while accumulating mutations. All reports sug- The Role of Microcirculatory Dysfunction gestacausalrelationshipbetween rubella viruspersistence inthe in the Pathophysiology and Treatment 1-4 skinandgranulomadevelopment.

Journal

JAMA DermatologyAmerican Medical Association

Published: Jul 15, 2019

References