Abstract Albumin turnover was measured in a whole body counter in six normal infants and 12 infants with iron deficiency anemia following the intravenous injection of 0.12 microcuries of iodinated I 131 serum albumin. Seven of the 12 patients had a rapid turnover (half-times less than ten days) which indicated significant exudative enteropathy. Treatment with iron dextran injection (100 mg parenterally) had no effect on the albumin turnover. Feeding evaporated milk instead of fresh cow's milk was followed by a lengthening of albumin turnover half-times in four out of five patients. Replacement of milk by a soybean substitute was always followed by a return to normal values. These observations suggest that there is a spectrum of effects of fresh cow's milk on the intestinal tract which are not due to iron deficiency. References 1. Wilson JF, Heiner DC, Lahey ME: Studies on iron metabolism: IV. Milk-induced gastrointestinal bleeding in infants with hypochromic microcytic anemia . JAMA 189:568-572, 1964.Crossref 2. Hoag MS, Wallerstein RO, Pollycove M: Occult blood loss in iron deficiency anemia of infancy . Pediatrics 27:199-203, 1961. 3. Schubert WK, Lahey ME: Copper and protein depletion complicating hypoferric anemia of infancy . Pediatrics 24:710-733, 1959. 4. Naiman JL, Oski FA, Diamond LK, et al: The gastrointestinal effects of iron deficiency anemia . Pediatrics 33:83-99, 1964. 5. Visakorpi JK, Kuitunen P: Intestinal absorption and mucosal histology in iron deficiency anaemia in children . Ann Paediat Fenn 12:251-256, 1966. 6. Guha DK, Walia BNS, Tandon BN, et al: Smallbowel changes in iron deficiency anaemia of childhood . Arch Dis Child 43:239-244, 1968.Crossref 7. Waldman TA: Protein-losing enteropathy . Gastroenterology 50:422-443, 1966. 8. Waldman TA, Wochner RD, Strober W: The role of the gastrointestinal tract in plasma protein metabolism . Amer J Med 46:275-285, 1969.Crossref 9. MacDonald NS, Hayes M, Figueroa WG: Medical utility of a total body counter—a four-year assessment . J Nucl Med 8:588-600, 1967. 10. Holt PR: Dietary treatment of protein loss in intestinal lymphangiectasia . Pediatrics 34:629-635, 1964. 11. Walker WA, Ulstrom RA, Lowman JT: Albumin synthesis rates in patients with hypoproteinemia . J Pediat 78:812-820, 1971.Crossref 12. Woodruff CW: A micromethod for serum iron determination . J Lab Clin Med 53:955-957, 1959. 13. Ressler N, Zak B: Serum unsaturated iron-binding capacity . Amer J Clin Path 30:87-90, 1958. 14. Wilson CS, Schaeffer AE, Darby WJ: A review of methods used in nutrition surveys conducted by the Interdepartmental Committee on Nutrition for National Defense . Amer J Clin Nutr 15:29-44, 1964. 15. Markowitz H, Shields GS, Klassen WH, et al: Spectrophotometric determination of total erythrocyte copper . Anal Chem 33:1594-1598, 1961.Crossref 16. Crowle AJ: Immunodiffusion . New York, Academic Press Inc, 1961. 17. Saxena KM, Chapman EM, Pryles CV: Minimal dosage of iodide required to suppress uptake of iodine-131 by normal thyroid . Science 138:430-431, 1962.Crossref 18. Coffman WJ: Manual for use of 2Π liquid scintillation counter. Special Report 88, Agricultural Experiment Station. University of Missouri, 1968. 19. Dallman PR, Sunshine P, Leonard Y: Intestinal cytochrome response with repair of iron deficiency . Pediatrics 39:863-871, 1967. 20. Katz J, Spiro HM, Herskovic T: Milk precipitating substance in the stool in gastrointestinal milk sensitivity . New Eng J Med 278:1191-1194, 1968.Crossref 21. Lahey ME: Iron Nutrition in Infancy: Report of the 62nd Ross Conference on Pediatric Research . Columbus, Ohio, Ross Laboratories, 1970, p 119.
American Journal of Diseases of Children – American Medical Association
Published: Jul 1, 1972