Abstract A clear understanding of the pathogenesis of macular degeneration would be a major addition to our knowledge of pathology, and more important, would give us the possibility of a rational therapy. Past work on this subject has pointed to changes in the lamina vitrea and changes in the choriocapillaris as possible origins of the breakdown that occurs.1-4 Routine histological sections of the retina have failed to show any significant alteration in the retinal vascular system in relation to this disease process. Our population of aged persons has grown tremendously in the last few years and statistical studies have shown macular degeneration after age 65 to involve to some degree almost one third of all eyes studied.5 Macular degeneration as seen in the early years of life on the basis of heredodegenerative disease is relatively a rarity. The macula does become involved in the generalized retinopathy of such conditions References 1. Kornzweig, A.L.; Feldstein, M.; and Schneider, J.: The Pathogenesis of Senile Macular Degeneration , Amer J Ophthal 48:22-28, 1959. 2. Elwyn, H.: Heredo-degeneration and Heredo-constitutional Defects of the Retina , Arch Ophthal 53:619-633, 1955.Crossref 3. Klien, B.A.: Heredo-degeneration of the Macula Lutea , Amer J Ophthal 33:371-379, 1950. 4. Hogan, M.J., and Zimmerman, L.E., eds., Ophthalmic Pathology: An Atlas and Textbook , ed 2, Philadelphia: W.B. Saunders Co., 1962, p 535. 5. Kornzweig, A.L.; Feldstein, M.; and Schneider, J.: Eye in Old Age: IV. Ocular Survey of Over 1000 Aged Persons with Special Reference to Normal and Disturbed Visual Function , Amer J Ophthal , 44:29-37, 1957. 6. Kuwabara, T., and Cogan, D.G.: Studies of Retinal Vascular Patterns: I. Normal Architecture . Arch Ophthal , 64:904-911, 1960.Crossref 7. Kornzweig, A.L.; Eliasoph, I.; and Feldstein, M.: Retinal Vasculature in the Aged , Bull NY Acad Med , 40:116-129, 1964. 8. Reinecke, R.D., et al: Retinal Vascular Patterns: V. Experimental Ischemia of the Cat Eye . Arch Ophthal , 67:470-475, 1962.Crossref 9. Kornzweig, A.L.; Eliasoph, I.; and Feldstein, M.: Occlusive Disease of Retinal Vasculature . Arch Ophthal 71:542-551, 1964.Crossref 10. Kuwabara, T.; Carroll, J.M.; and Cogan, D.G.: Retinal Vascular Patterns: III. Age, Hypertension, Absolute Glaucoma and Injury , Arch Ophthal 65:708, 1961.Crossref 11. Ashton, N.: " Diabetic Retinopathy ," in Disorders of Carbohydrate Metabolism, proceedings of conference at Royal College of Physicians, London, March, 1962 . D. A. Pyke, (ed.), London: Pitman Medical Publishers Co., 1962, pp 195-206.
Archives of Ophthalmology – American Medical Association
Published: Mar 1, 1966
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera