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The Retinal Vasculature in Macular Degeneration

The Retinal Vasculature in Macular Degeneration Abstract A clear understanding of the pathogenesis of macular degeneration would be a major addition to our knowledge of pathology, and more important, would give us the possibility of a rational therapy. Past work on this subject has pointed to changes in the lamina vitrea and changes in the choriocapillaris as possible origins of the breakdown that occurs.1-4 Routine histological sections of the retina have failed to show any significant alteration in the retinal vascular system in relation to this disease process. Our population of aged persons has grown tremendously in the last few years and statistical studies have shown macular degeneration after age 65 to involve to some degree almost one third of all eyes studied.5 Macular degeneration as seen in the early years of life on the basis of heredodegenerative disease is relatively a rarity. The macula does become involved in the generalized retinopathy of such conditions References 1. Kornzweig, A.L.; Feldstein, M.; and Schneider, J.: The Pathogenesis of Senile Macular Degeneration , Amer J Ophthal 48:22-28, 1959. 2. Elwyn, H.: Heredo-degeneration and Heredo-constitutional Defects of the Retina , Arch Ophthal 53:619-633, 1955.Crossref 3. Klien, B.A.: Heredo-degeneration of the Macula Lutea , Amer J Ophthal 33:371-379, 1950. 4. Hogan, M.J., and Zimmerman, L.E., eds., Ophthalmic Pathology: An Atlas and Textbook , ed 2, Philadelphia: W.B. Saunders Co., 1962, p 535. 5. Kornzweig, A.L.; Feldstein, M.; and Schneider, J.: Eye in Old Age: IV. Ocular Survey of Over 1000 Aged Persons with Special Reference to Normal and Disturbed Visual Function , Amer J Ophthal , 44:29-37, 1957. 6. Kuwabara, T., and Cogan, D.G.: Studies of Retinal Vascular Patterns: I. Normal Architecture . Arch Ophthal , 64:904-911, 1960.Crossref 7. Kornzweig, A.L.; Eliasoph, I.; and Feldstein, M.: Retinal Vasculature in the Aged , Bull NY Acad Med , 40:116-129, 1964. 8. Reinecke, R.D., et al: Retinal Vascular Patterns: V. Experimental Ischemia of the Cat Eye . Arch Ophthal , 67:470-475, 1962.Crossref 9. Kornzweig, A.L.; Eliasoph, I.; and Feldstein, M.: Occlusive Disease of Retinal Vasculature . Arch Ophthal 71:542-551, 1964.Crossref 10. Kuwabara, T.; Carroll, J.M.; and Cogan, D.G.: Retinal Vascular Patterns: III. Age, Hypertension, Absolute Glaucoma and Injury , Arch Ophthal 65:708, 1961.Crossref 11. Ashton, N.: " Diabetic Retinopathy ," in Disorders of Carbohydrate Metabolism, proceedings of conference at Royal College of Physicians, London, March, 1962 . D. A. Pyke, (ed.), London: Pitman Medical Publishers Co., 1962, pp 195-206. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Retinal Vasculature in Macular Degeneration

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1966.00970050328005
Publisher site
See Article on Publisher Site

Abstract

Abstract A clear understanding of the pathogenesis of macular degeneration would be a major addition to our knowledge of pathology, and more important, would give us the possibility of a rational therapy. Past work on this subject has pointed to changes in the lamina vitrea and changes in the choriocapillaris as possible origins of the breakdown that occurs.1-4 Routine histological sections of the retina have failed to show any significant alteration in the retinal vascular system in relation to this disease process. Our population of aged persons has grown tremendously in the last few years and statistical studies have shown macular degeneration after age 65 to involve to some degree almost one third of all eyes studied.5 Macular degeneration as seen in the early years of life on the basis of heredodegenerative disease is relatively a rarity. The macula does become involved in the generalized retinopathy of such conditions References 1. Kornzweig, A.L.; Feldstein, M.; and Schneider, J.: The Pathogenesis of Senile Macular Degeneration , Amer J Ophthal 48:22-28, 1959. 2. Elwyn, H.: Heredo-degeneration and Heredo-constitutional Defects of the Retina , Arch Ophthal 53:619-633, 1955.Crossref 3. Klien, B.A.: Heredo-degeneration of the Macula Lutea , Amer J Ophthal 33:371-379, 1950. 4. Hogan, M.J., and Zimmerman, L.E., eds., Ophthalmic Pathology: An Atlas and Textbook , ed 2, Philadelphia: W.B. Saunders Co., 1962, p 535. 5. Kornzweig, A.L.; Feldstein, M.; and Schneider, J.: Eye in Old Age: IV. Ocular Survey of Over 1000 Aged Persons with Special Reference to Normal and Disturbed Visual Function , Amer J Ophthal , 44:29-37, 1957. 6. Kuwabara, T., and Cogan, D.G.: Studies of Retinal Vascular Patterns: I. Normal Architecture . Arch Ophthal , 64:904-911, 1960.Crossref 7. Kornzweig, A.L.; Eliasoph, I.; and Feldstein, M.: Retinal Vasculature in the Aged , Bull NY Acad Med , 40:116-129, 1964. 8. Reinecke, R.D., et al: Retinal Vascular Patterns: V. Experimental Ischemia of the Cat Eye . Arch Ophthal , 67:470-475, 1962.Crossref 9. Kornzweig, A.L.; Eliasoph, I.; and Feldstein, M.: Occlusive Disease of Retinal Vasculature . Arch Ophthal 71:542-551, 1964.Crossref 10. Kuwabara, T.; Carroll, J.M.; and Cogan, D.G.: Retinal Vascular Patterns: III. Age, Hypertension, Absolute Glaucoma and Injury , Arch Ophthal 65:708, 1961.Crossref 11. Ashton, N.: " Diabetic Retinopathy ," in Disorders of Carbohydrate Metabolism, proceedings of conference at Royal College of Physicians, London, March, 1962 . D. A. Pyke, (ed.), London: Pitman Medical Publishers Co., 1962, pp 195-206.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1966

References

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