Abstract The results reported in a foregoing paper1 show that because of the diversity of anatomic renal defects orthostatic albuminuria cannot be regarded as a distinct disease entity. Even the purely clinical definition of orthostatic albuminuria shows a lack of precision. It is incorrect to state that orthostatic albuminuria is a condition characterized by the presence of albumin in the urine while the subject is erect and by the absence of albumin in the urine while he is supine, because albumin (protein) is always present under all conditions. What is really meant is that more albumin is present under certain circumstances than under others. Since this is the case, quantitative methods are essential. The same five subjects with orthostatic albuminuria who were studied roentgenographically after the injection of diodrast, reported on in the foregoing paper,1 were further investigated by means of the Addis urea ratio, the Rehberg (creatinine) glomerular References 1. Rytand, D. A.: Roentgenographic Study of Orthostatic Albuminuria by Means of Injections of Diodrast , Arch. Int. Med. , this issue, p. 837. 2. MacKay, E. M., and Rytand, D. A.: Significance of Phenolsulphonphthalein Test of Renal Function , Arch. Int. Med. 60:131 ( (Jan.) ) 1935.Crossref 3. Medes, G., and Neemes, M.: Orthostatic Proteinuria , in Berglund, H., and Medes, G.: The Kidney in Health and Disease , Philadelphia, Lea & Febiger, 1935, p. 462. 4. White, H. L.; Rosen, I. T.; Fischer, S. S., and Wood, G. H.: The Influence of Posture on Renal Activity , Am. J. Physiol. 178:185 ( (Sept.) ) 1926. 5. Van Slyke, D. D.; Alving, A., and Rose, W. C.: Studies of Urea Excretion: VII. The Effects of Posture and Exercise on Urea Excretion , J. Clin. Investigation 11:1053 ( (Sept.) ) 1932.Crossref 6. Addis, T., and Watanabe, C. K.: A Method for the Measurement of the Urea-Excreting Function of the Kidney , J. Biol. Chem. 28:251 ( (Dec.) ) 1916. 7. Rehberg, P. B.: Studies on Kidney Function: I. The Rate of Filtration and Reabsorption in the Human Kidney , Biochem. J. 20:447 ( (April 26) ) 1926 8. II. The Excretion of Urea and Chlorine Analyzed According to a Modified Filtration-Reabsorption Theory , Rehberg Biochem. J. (April 26) 20:461, 1926. 9. Addis, T.: A Clinical Classification of Bright's Disease , J. A. M. A. 85: 163 ( (July 18) ) 1925.Crossref 10. Heubner, O.: Die chronischen Albuminurien im Kindesalter , Ergebn. d. inn. Med. u. Kinderh. 2:567, 1908. 11. Holst, P. F.: Orthostatic Albuminuria and Its Relation to Nephritis , Norsk mag. f. lægevidensk. 13:1377, 1915 12. J. A. M. A. 65:2206 ( (Dec. 18) ) 1915. 13. Fishberg, A. M.: Hypertension and Nephritis , ed. 2, Philadelphia, Lea & Febiger, 1931, p. 257. 14. Hartwich, A.: Die gutartigen Albuminurien , Ergebn. d. inn. Med. u. Kinderh. 38:44, 1930. 15. Addis, T.: Renal Failure Casts , J. A. M. A. 84:1013 ( (April 4) ) 1925.Crossref 16. Barnett, G. D., and Barnett, C. W.: Unpublished observations. 17. Addis, T., and Oliver, J.: The Renal Lesion in Bright's Disease , New York, Paul B. Hoeber, Inc., 1931, p. 140. 18. Chapman, E. M., and Halsted, J. A.: The Fractional Phenolsulphonphthalein Test in Bright's Disease , Am. J. M. Sc. 186:223 ( (July) ) 1933.Crossref
Archives of Internal Medicine – American Medical Association
Published: May 1, 1937
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