Abstract It was noted at autopsy in a study of animals dying after the removal of both adrenals that the pancreas always presents a characteristic appearance. In color the gland is deep pink and contrasts quite strikingly with the faint white color of the normal pancreas. Because of their marked injection, it is possible to see all the vessels by transmitted light; even those leading to the small lobules stand out prominently. Histologically the islands appear prominent and the capillaries are engorged with blood. This appearance is only slightly simulated by that of the fatigue gland at the end of a long period of digestion. Since these changes in the pancreas were so marked and constant, we deemed them worthy of a separate investigation. This seemed especially desirable as accurate data in regard to the polyglandular theory are very scant. We found only one reference describing a seemingly References 1. Sweet, J. E., and Allen, A. R.: The Effect of the Removal of the Hypophysis in the Dog , Ann. Surg. , 1913, lvii, 485, 3 pl.Crossref 2. Lusk, Graham, and Riche, J. A.: Animal Calorimetry : Paper VIII. The Alleged Influence of the Adrenals on Diabetic Metabolism , The Archives Int. Med. , 1914, xiii, 673.Crossref 3. Crowe, S. J., and Wislocki, G. B.: Experimental Observation on Adrenals with Reference to Functions of their Interrenal Portions , Bull. Johns Hopkins Hosp. , 1914, xxv, No. (284) . 4. Pemberton, Ralph, and Sweet, J. E.: The Inhibition of Pancreatic Activity by Extracts of Suprarenal and Pituitary Bodies , The Archives Int. Med. , 1908, i, 628-647Crossref 5. Further Studies on the Influence of the Ductless Glands on the Pancreas , Pemberton The Archives Int. Med. , 1910, v, 466Crossref 6. Sweet, J. E., and Pemberton, Ralph: The Induction of Pancreatic Activity by the Removal of the Adrenals , The Archives Int. Med. , 1910, vi, 536Crossref 7. Pemberton, Ralph, and Sweet, J. E.: Experimental Notes on the Influence of the Adrenals Over the Pancreas , The Archives Int. Med. , 1912, ix, 169.Crossref 8. Edmunds, C. W.: Further Study of the Relation of the Adrenals to Pancreatic Activity , Jour. Pharm. and Exper. Therap. , 1910-11, ii, 559 9. The Antagonism of the Adrenal Glands Against the Pancreas , Edmunds Jour. Pharm. and Exper. Therap. , 1909-10, i, 135. 10. Bensley: Studies on the Pancreas of the Guinea-Pig , Am. Jour. Anat. , 1911-12, xii, 297.Crossref
Archives of Internal Medicine – American Medical Association
Published: Oct 1, 1915
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