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THE RELATION OF THE ADRENAL GLAND TO THE TOXEMIA OF INTESTINAL OBSTRUCTION: AN EXPERIMENTAL STUDY

THE RELATION OF THE ADRENAL GLAND TO THE TOXEMIA OF INTESTINAL OBSTRUCTION: AN EXPERIMENTAL STUDY Abstract A rather considerable volume of experimental and controversial literature on the general subject of intestinal obstruction has appeared within recent years and has served to focus the interest of the surgeon on this interesting, and often most trying, condition. Much of interest has apparently been demonstrated as to both pathology and treatment, considerably more has been surmised and hypothecated, and still more is as yet unknown. From a practical point of view the alkalosis and dehydration which occur, particularly in so-called "high intestinal obstruction," and the diminished chloride content of the blood plasma, have served as valuable points of departure for therapeutic measures, but rather obviously the correction of such abnormalities partakes of the nature of symptomatic rather than curative treatment. The treatment for certain types of obstruction by the administration of spinal anesthesia has been successfully used by many clinicians, especially in the European clinics, and is rational in References 1. Murphy, F. T., and Vincent, Beth: An Experimental Study on the Cause of Death in Intestinal Obstruction , Boston M. & S. J. 165:684, 1911. 2. Murphy, F. T., and Brooks, B.: Intestinal Obstruction: An Experimental Study of the Cause of Symptoms and Death , Arch. Int. Med. 15:392 ( (March) ) 1915. 3. Copher, G. H., and Brooks, B.: Intestinal Obstruction: An Experimental Study of the Therapeutic Value of the Administration of Sodium Chloride , Ann. Surg. 78:755, 1923. 4. Dragstedt, C. A.; Dragstedt, L. R., and Chase, C. S.: The Antigenic Property of Closed Intestinal Loop Fluid , Am. J. Physiol. 46:366, 1918. 5. Clairmont, P., and Ranzi, E.: Zur Frage der autointoxication bei ileus , Arch. f. klin. Chir. 73:698, 1904. 6. Stone, H. B.; Bernheim, B. M., and Whipple, G. K.: Intestinal Obstruction: A Study of the Toxic Factors , Bull. Johns Hopkins Hosp. 23:159, 1912. 7. Whipple, G. H.; Cooke, J. V., and Stearns, T.: Proteose Intoxication and Injury of Body Protein: II. Metabolism of Dogs with Duodenal Obstruction and Isolated Loops , J. Exper. Med. 25:479, 1917. 8. Davis, D. M., and Morgan, H. S.: Natural Immunity of Animals Against Poison of Intestinal Obstruction , Bull. Johns Hopkins Hosp. 25:39, 1914. 9. Ellis, J. W.: Cause of Death in High Intestinal Obstruction , Ann. Surg. 75:429, 1922. 10. Sugito, S.: Ueber die Todenursache bei Ileus , Mitt. a. d. med. Fak. d. k. Univ. Kyushu., Fukuoka 9:229, 1924. 11. Stone, H. B.; Bernheim, B. M., and Whipple, G. K.: The Experimental Study of Intestinal Obstruction , Ann. Surg. 59:714, 1914. 12. Whipple, G. H.; Rodenbaugh, F. H., and Kilgore, A. R.: Proteose Intoxication , J. Exper. Med. 23:123, 1916. 13. Wilkie, D. P. D.: Acute Intestinal Obstruction , Lancet 1:1135, 1922. 14. Stone, H. B.: The Toxic Agents Developed in the Course of Acute Intestinal Obstruction and Their Action , Surg. Gynec. Obst. 32:415, 1921. 15. Gerard, R. W.: The Lethal Agent in Acute Intestinal Obstruction , J. A. M. A. 79:1581 ( (Nov. 24) ) 1924. 16. Ingvaldsen, T.; Whipple, A. O.; Bauman, L., and Smith, B. C.: The Rôle of Anhydremia and the Nature of the Toxin in Intestinal Obstruction , J. Exper. Med. 39:117, 1924. 17. Boinet, E.: Diminution de résistance des rats doublement décapsules a l'action toxique de diverséssubstances , Compt. rend. Soc. de biol. 49:466, 1897. 18. Scott, W. J. M.: Influence of Adrenal Glands on Resistance; Susceptibility of Adrenalectomized Rats to Morphine , J. Exper. Med. 38:543, 1923 19. Influence of Adrenal Glands on Resistance; Toxic Effect of Killed Bacteria in Adrenalectomized Rats , Scott J. Exper. Med. 39:457, 1924 20. Influence of Adrenal Glands on Resistance; Susceptibility to Histamine as Test of Adrenal Deficiency , Scott J. Exper. Med. 47:185, 1928. 21. Marine, D., and Baumann, E. J.: Duration of Life After Suprarenalectomy; an Attempt to Prolong it by Injection of Solution Containing Sodium Salts, Glucose and Glycerol , Am. J. Physiol. 81:86, 1927. 22. Belding, D. L., and Wyman, L. C.: Rôle of Suprarenal Gland in Natural Resistance of Rat to Diphtheric Toxin , Am. J. Physiol. 78:50, 1926. 23. Crivellari, C. A.: Sensitiveness of Adrenalectomized Rats to Certain Toxic Substances , Am. J. Physiol. 81:414, 1927. 24. Lewis, J. T.: Sensibilité des rats prives de surrénales envers les toxiques , Compt. rend. de 1. Séances Soc. de Biol. , (Jan. 22) , 1921. 25. Meyers: Tr. Path. Soc. London , 1898. 26. Jaffe, H. L.: On Diminished Resistance Following Suprarenalectomy in the Rat and the Protection Afforded by Autoplastic Transplants ; Am. J. Path. 2:421, 1926. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

THE RELATION OF THE ADRENAL GLAND TO THE TOXEMIA OF INTESTINAL OBSTRUCTION: AN EXPERIMENTAL STUDY

Archives of Surgery , Volume 19 (2) – Aug 1, 1929

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Publisher
American Medical Association
Copyright
Copyright © 1929 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1929.01150020105002
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Abstract

Abstract A rather considerable volume of experimental and controversial literature on the general subject of intestinal obstruction has appeared within recent years and has served to focus the interest of the surgeon on this interesting, and often most trying, condition. Much of interest has apparently been demonstrated as to both pathology and treatment, considerably more has been surmised and hypothecated, and still more is as yet unknown. From a practical point of view the alkalosis and dehydration which occur, particularly in so-called "high intestinal obstruction," and the diminished chloride content of the blood plasma, have served as valuable points of departure for therapeutic measures, but rather obviously the correction of such abnormalities partakes of the nature of symptomatic rather than curative treatment. The treatment for certain types of obstruction by the administration of spinal anesthesia has been successfully used by many clinicians, especially in the European clinics, and is rational in References 1. Murphy, F. T., and Vincent, Beth: An Experimental Study on the Cause of Death in Intestinal Obstruction , Boston M. & S. J. 165:684, 1911. 2. Murphy, F. T., and Brooks, B.: Intestinal Obstruction: An Experimental Study of the Cause of Symptoms and Death , Arch. Int. Med. 15:392 ( (March) ) 1915. 3. Copher, G. H., and Brooks, B.: Intestinal Obstruction: An Experimental Study of the Therapeutic Value of the Administration of Sodium Chloride , Ann. Surg. 78:755, 1923. 4. Dragstedt, C. A.; Dragstedt, L. R., and Chase, C. S.: The Antigenic Property of Closed Intestinal Loop Fluid , Am. J. Physiol. 46:366, 1918. 5. Clairmont, P., and Ranzi, E.: Zur Frage der autointoxication bei ileus , Arch. f. klin. Chir. 73:698, 1904. 6. Stone, H. B.; Bernheim, B. M., and Whipple, G. K.: Intestinal Obstruction: A Study of the Toxic Factors , Bull. Johns Hopkins Hosp. 23:159, 1912. 7. Whipple, G. H.; Cooke, J. V., and Stearns, T.: Proteose Intoxication and Injury of Body Protein: II. Metabolism of Dogs with Duodenal Obstruction and Isolated Loops , J. Exper. Med. 25:479, 1917. 8. Davis, D. M., and Morgan, H. S.: Natural Immunity of Animals Against Poison of Intestinal Obstruction , Bull. Johns Hopkins Hosp. 25:39, 1914. 9. Ellis, J. W.: Cause of Death in High Intestinal Obstruction , Ann. Surg. 75:429, 1922. 10. Sugito, S.: Ueber die Todenursache bei Ileus , Mitt. a. d. med. Fak. d. k. Univ. Kyushu., Fukuoka 9:229, 1924. 11. Stone, H. B.; Bernheim, B. M., and Whipple, G. K.: The Experimental Study of Intestinal Obstruction , Ann. Surg. 59:714, 1914. 12. Whipple, G. H.; Rodenbaugh, F. H., and Kilgore, A. R.: Proteose Intoxication , J. Exper. Med. 23:123, 1916. 13. Wilkie, D. P. D.: Acute Intestinal Obstruction , Lancet 1:1135, 1922. 14. Stone, H. B.: The Toxic Agents Developed in the Course of Acute Intestinal Obstruction and Their Action , Surg. Gynec. Obst. 32:415, 1921. 15. Gerard, R. W.: The Lethal Agent in Acute Intestinal Obstruction , J. A. M. A. 79:1581 ( (Nov. 24) ) 1924. 16. Ingvaldsen, T.; Whipple, A. O.; Bauman, L., and Smith, B. C.: The Rôle of Anhydremia and the Nature of the Toxin in Intestinal Obstruction , J. Exper. Med. 39:117, 1924. 17. Boinet, E.: Diminution de résistance des rats doublement décapsules a l'action toxique de diverséssubstances , Compt. rend. Soc. de biol. 49:466, 1897. 18. Scott, W. J. M.: Influence of Adrenal Glands on Resistance; Susceptibility of Adrenalectomized Rats to Morphine , J. Exper. Med. 38:543, 1923 19. Influence of Adrenal Glands on Resistance; Toxic Effect of Killed Bacteria in Adrenalectomized Rats , Scott J. Exper. Med. 39:457, 1924 20. Influence of Adrenal Glands on Resistance; Susceptibility to Histamine as Test of Adrenal Deficiency , Scott J. Exper. Med. 47:185, 1928. 21. Marine, D., and Baumann, E. J.: Duration of Life After Suprarenalectomy; an Attempt to Prolong it by Injection of Solution Containing Sodium Salts, Glucose and Glycerol , Am. J. Physiol. 81:86, 1927. 22. Belding, D. L., and Wyman, L. C.: Rôle of Suprarenal Gland in Natural Resistance of Rat to Diphtheric Toxin , Am. J. Physiol. 78:50, 1926. 23. Crivellari, C. A.: Sensitiveness of Adrenalectomized Rats to Certain Toxic Substances , Am. J. Physiol. 81:414, 1927. 24. Lewis, J. T.: Sensibilité des rats prives de surrénales envers les toxiques , Compt. rend. de 1. Séances Soc. de Biol. , (Jan. 22) , 1921. 25. Meyers: Tr. Path. Soc. London , 1898. 26. Jaffe, H. L.: On Diminished Resistance Following Suprarenalectomy in the Rat and the Protection Afforded by Autoplastic Transplants ; Am. J. Path. 2:421, 1926.

Journal

Archives of SurgeryAmerican Medical Association

Published: Aug 1, 1929

References