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THE QUANTITATIVE KAHN PROCEDURE WITH STANDARD AND SENSITIZED ANTIGENS

THE QUANTITATIVE KAHN PROCEDURE WITH STANDARD AND SENSITIZED ANTIGENS Abstract It was shown elsewhere1 that the regular Kahn test with standard antigen is considerably less sensitive than the presumptive procedure which employs sensitized antigen. In the general run of cases observed in the University Hospital, the presumptive procedure is 2.5 per cent more sensitive and in patients treated for syphilis 26 per cent more sensitive than the regular test. The question arose as to the comparative sensitiveness of the quantitative Kahn procedure when the standard and sensitized antigens were employed. It will be recalled that the quantitative procedure gives the potency of syphilitic serums in terms of Kahn units.2 One of several serums giving 4 plus reactions might indicate 800 units, another 400 and still another perhaps 120. These units are determined by the performance of the precipitation reaction with a series of serum dilutions under constant conditions. The highest dilution in which precipitation occurs establishes the number References 1. McDermott, E. B.: The Presumptive Kahn Procedure in Syphilis Based on Fifteen Thousand Examinations , Arch. Path. 8:661 ( (Oct.) ) 1929. 2. Kahn, R. L.: The Kahn Test, A Practical Guide , Baltimore, Williams & Wilkins Company, 1928, p. 134. 3. Kahn, R. L.: Serum Diagnosis of Syphilis by Precipitation , Baltimore, Williams & Wilkins, 1925, p. 148. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

THE QUANTITATIVE KAHN PROCEDURE WITH STANDARD AND SENSITIZED ANTIGENS

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Publisher
American Medical Association
Copyright
Copyright © 1929 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1929.01440060096009
Publisher site
See Article on Publisher Site

Abstract

Abstract It was shown elsewhere1 that the regular Kahn test with standard antigen is considerably less sensitive than the presumptive procedure which employs sensitized antigen. In the general run of cases observed in the University Hospital, the presumptive procedure is 2.5 per cent more sensitive and in patients treated for syphilis 26 per cent more sensitive than the regular test. The question arose as to the comparative sensitiveness of the quantitative Kahn procedure when the standard and sensitized antigens were employed. It will be recalled that the quantitative procedure gives the potency of syphilitic serums in terms of Kahn units.2 One of several serums giving 4 plus reactions might indicate 800 units, another 400 and still another perhaps 120. These units are determined by the performance of the precipitation reaction with a series of serum dilutions under constant conditions. The highest dilution in which precipitation occurs establishes the number References 1. McDermott, E. B.: The Presumptive Kahn Procedure in Syphilis Based on Fifteen Thousand Examinations , Arch. Path. 8:661 ( (Oct.) ) 1929. 2. Kahn, R. L.: The Kahn Test, A Practical Guide , Baltimore, Williams & Wilkins Company, 1928, p. 134. 3. Kahn, R. L.: Serum Diagnosis of Syphilis by Precipitation , Baltimore, Williams & Wilkins, 1925, p. 148.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Dec 1, 1929

References