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The Prolonged Administration of Streptomycin Hydrosulfate: The Effect on Hearing

The Prolonged Administration of Streptomycin Hydrosulfate: The Effect on Hearing Abstract The low incidence of hearing loss resulting from the administration of streptomycin hydrosulfate in the treatment of pulmonary and other forms of tuberculosis has been previously reported.* These reports covered patients who were under treatment at Veterans Administration tuberculosis facilities and other institutions for the treatment of tuberculosis. The period of observation varied from 42 days2 to 8 months.† In recent years the treatment of non-surgical pulmonary tuberculosis has been shifting from hospital and sanitarium care to home care with periodic check-ups in out-patient clinics. Because of the high incidence rate of relapse in "arrested" cases of tuberculosis of the lung prior to chemotherapy and the low incidence of relapse of those patients who continue indefinitely on chemotherapy after discharge from the hospital, Dooneief, Hite, and Bloch ‡ advocated "chemotherapy under close observation should be prolonged indefinitely except in the presence of threatening side effects or until References 1. Brown, H. A., and Hinshaw, H. C.: Toxic Reaction of Streptomycin on the Eighth Nerve Apparatus , Proc. Staff Meet. Mayo Clin. 21:347-352 ( (Sept. 4) ) 1946. 2. Proceedings of the Seventh Streptomycin Conference, Washington, D. C., U. S. Government Printing Office, 1949, pp. 121-125. 3. Tempel, C. W., and others: Isoniazid-Streptomycin in the Treatment of Pulmonary Tuberculosis, in Transactions of the 12th Conference on Chemotherapy of Tuberculosis, Washington, D. C., U. S. Government Printing Office, 1953, pp. 80-88. 4. Heck, W. E.; Lynch, W. J., and Graves, H. L.: A Controlled Comparison of the Eighth Nerve Toxicity of Streptomycin and Dihydrostreptomycin , Ann. Otol. Rhin. & Laryng. 62:101-106 ( (March) ) 1953. 5. Andersen, H. C., and Ohrt, H. H.: Vestibular and Acoustic Symptoms and Other Phenomena Following Treatment with Streptomycin and Dihydrostreptomycin , J. Laryng. & Otol. 67:701-708 ( (Dec.) ) 1953. 6. Cline, H. L.; Houseworth, J. H., and Pitts, F. W.: Ototoxicity from Intermittent Streptomycin Sulfate Therapy of Pulmonary Tuberculosis , A. M.A. Arch. oto-laryng. 59:100-103 ( (Jan.) ) 1954. 7. Dooneief, A. S., and Hite, K. E.: Indefinitely Prolonged Chemotherapy for Tuberculosis: A Preliminary Report , Am. Rev. Tuberc. 70:219-227 ( (Aug.) ) 1954. 8. Dooneief, A. S.; Hite, K. E., and Bloch, R. G.: Indefinitely Prolonged Chemotherapy for Tuberculosis: An Appeal , A. M. A. Arch. Int. Med. 96:470-477 ( (Oct.) ) 1955. 9. Bunch, C. C.: Age Variations in Auditory Acuity , Arch. oto-laryng. 9:625-636 ( (June) ) 1929. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

The Prolonged Administration of Streptomycin Hydrosulfate: The Effect on Hearing

WITCHELL, IRA S.
A.M.A. Archives of Otolaryngology , Volume 64 (6) – Dec 1, 1956
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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1956.03830180064009
Publisher site
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Abstract

Abstract The low incidence of hearing loss resulting from the administration of streptomycin hydrosulfate in the treatment of pulmonary and other forms of tuberculosis has been previously reported.* These reports covered patients who were under treatment at Veterans Administration tuberculosis facilities and other institutions for the treatment of tuberculosis. The period of observation varied from 42 days2 to 8 months.† In recent years the treatment of non-surgical pulmonary tuberculosis has been shifting from hospital and sanitarium care to home care with periodic check-ups in out-patient clinics. Because of the high incidence rate of relapse in "arrested" cases of tuberculosis of the lung prior to chemotherapy and the low incidence of relapse of those patients who continue indefinitely on chemotherapy after discharge from the hospital, Dooneief, Hite, and Bloch ‡ advocated "chemotherapy under close observation should be prolonged indefinitely except in the presence of threatening side effects or until References 1. Brown, H. A., and Hinshaw, H. C.: Toxic Reaction of Streptomycin on the Eighth Nerve Apparatus , Proc. Staff Meet. Mayo Clin. 21:347-352 ( (Sept. 4) ) 1946. 2. Proceedings of the Seventh Streptomycin Conference, Washington, D. C., U. S. Government Printing Office, 1949, pp. 121-125. 3. Tempel, C. W., and others: Isoniazid-Streptomycin in the Treatment of Pulmonary Tuberculosis, in Transactions of the 12th Conference on Chemotherapy of Tuberculosis, Washington, D. C., U. S. Government Printing Office, 1953, pp. 80-88. 4. Heck, W. E.; Lynch, W. J., and Graves, H. L.: A Controlled Comparison of the Eighth Nerve Toxicity of Streptomycin and Dihydrostreptomycin , Ann. Otol. Rhin. & Laryng. 62:101-106 ( (March) ) 1953. 5. Andersen, H. C., and Ohrt, H. H.: Vestibular and Acoustic Symptoms and Other Phenomena Following Treatment with Streptomycin and Dihydrostreptomycin , J. Laryng. & Otol. 67:701-708 ( (Dec.) ) 1953. 6. Cline, H. L.; Houseworth, J. H., and Pitts, F. W.: Ototoxicity from Intermittent Streptomycin Sulfate Therapy of Pulmonary Tuberculosis , A. M.A. Arch. oto-laryng. 59:100-103 ( (Jan.) ) 1954. 7. Dooneief, A. S., and Hite, K. E.: Indefinitely Prolonged Chemotherapy for Tuberculosis: A Preliminary Report , Am. Rev. Tuberc. 70:219-227 ( (Aug.) ) 1954. 8. Dooneief, A. S.; Hite, K. E., and Bloch, R. G.: Indefinitely Prolonged Chemotherapy for Tuberculosis: An Appeal , A. M. A. Arch. Int. Med. 96:470-477 ( (Oct.) ) 1955. 9. Bunch, C. C.: Age Variations in Auditory Acuity , Arch. oto-laryng. 9:625-636 ( (June) ) 1929.

Journal

A.M.A. Archives of Otolaryngology – American Medical Association

Published: Dec 1, 1956

References

  • Toxic Reaction of Streptomycin on the Eighth Nerve Apparatus
    Brown , H. A., and Hinshaw, H. C.
  • A Controlled Comparison of the Eighth Nerve Toxicity of Streptomycin and Dihydrostreptomycin
    Heck , W. E.; Lynch, W. J., and Graves, H. L.
  • Vestibular and Acoustic Symptoms and Other Phenomena Following Treatment with Streptomycin and Dihydrostreptomycin
    Andersen , H. C., and Ohrt, H. H.
  • Ototoxicity from Intermittent Streptomycin Sulfate Therapy of Pulmonary Tuberculosis
    Cline , H. L.; Houseworth, J. H., and Pitts, F. W.
  • Indefinitely Prolonged Chemotherapy for Tuberculosis: A Preliminary Report
    Dooneief , A. S., and Hite, K. E.
  • Indefinitely Prolonged Chemotherapy for Tuberculosis: An Appeal
    Dooneief , A. S.; Hite, K. E., and Bloch, R. G.
  • Age Variations in Auditory Acuity
    Bunch , C. C.