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THE PROBLEM OF WOUND HEALING: I. EFFECT OF LOCAL AGENTS

THE PROBLEM OF WOUND HEALING: I. EFFECT OF LOCAL AGENTS Abstract The surgical literature contains reports of the use of numerous topical substances purported to stimulate wound healing. It is my purpose in this article to consider the problem of their evaluation and to present the results obtained in a critical study of certain agents frequently used as wound dressings. HISTORICAL SURVEY The Edwin Smith Surgical Papyrus, the first written record in medical history and perhaps the earliest exegesis of the scientific method in human history, contains a discussion of the principles to be followed in the management of traumatic wounds. During the centuries, knowledge has accrued concerning both the mechanisms of repair and the therapeutics of wounds; yet today these subjects remain in the forefront of surgical thought as problems lacking final solution. The fact that surgeons have yet to attain perfection in the treatment of wounds apparently has constituted a challenge to investigators, judging from the multiplicity of substances References 1. Harvey, S. C.: Proc. Inst. Med. Chicago 10:70, 1934. 2. Carrel, A.: Proc. Inst. Med. Chicago 8:62, 1930. 3. Fisher, A.: Tissue Culture , Copenhagen, Levin & Munksgaard, 1925. 4. Reimann, S. P.: Proliferation of Rat and Mouse Epithelium from Sulphydryl , Protoplasma 10:82 ( (June) ) 1930.Crossref 5. Clark, A. H.: Bull. Johns Hopkins Hosp. 30:117, 1919. 6. Harvey, S. C., and Howes, E. L.: Ann. Surg. 91:641, 1930.Crossref 7. Lohr, W.: Med. Welt 8:1273, 1934. 8. Roegholt, N.: Nederl. tijdschr. v. geneesk. 2:3744, 1929. 9. Bird, C. E., and MacKay, E. M.: Surg., Gynec. & Obst. 54:872, 1932. 10. Rabinowitch, I. M.: Simultaneous Respiratory Exchange and Blood Sugar Time Curves Obtained in Apparently Nondiabetic Patients with Nonhealing Wounds , Arch. Surg. 26:696 ( (April) ) 1933. 11. Sullivan, E. A.: New England J. Med. 209:241, 1933. 12. Kosdoba, A. S.: Arch. f. klin. Chir. 179:435 and 551, 1934. 13. Ciantini, F.: Ann. ital. di chir. 12:1119, 1933. 14. Wheeler, B. C., and Adams, D. S.: New England J. Med. 211:630, 1934. 15. Carrel, A.: Compt. rend. Soc. de biol. 90:333, 1924 16. Hammett, F. S.: Protoplasma 7:297, 1929. 17. Carrel, A., and Hartmann, A.: J. Exper. Med. 24:429, 1916. 18. Du Noüy, P. L.: J. Exper. Med. 24:461 ( (Nov.) ) 1916. 19. Heuer, in Graham, E. A.; Singer, J. J., and Ballon, H. C.: Surgical Diseases of the Chest , Philadelphia, Lea & Febiger, 1935. 20. Brunsting, L. A., and Simonsen, D. G.: Cutaneous Ulcers Treated by Sulphydryl Containing Amino-Acid Cysteine , J. A. M. A. 101:1937 ( (Dec. 16) ) 1933. 21. Birnbaum, I. R.: Ann. Surg. 96:467, 1932. 22. Sutton, L. E.: Thioglycerol: A More Stable Sulphydryl Compound for Use in the Healing of Wounds , J. A. M. A. 104:2168 ( (June 15) ) 1931. 23. Hill, J. H.: The Action of Mercurochrome and Other Drugs on Normal Human Skin and in Infected Wounds , J. A. M. A. 105:100 ( (July 13) ) 1935.Crossref 24. Carrel, A., and Dehelly, G.: Treatment of Infected Wounds , New York, Paul B. Hoeber, Inc., 1916. 25. Wright, A.: Brit. M. J. 2:629, 1915.Crossref 26. The experiments on tissue cultures were performed in the laboratory of Dr. J. M. Hogue. 27. Lambert, R. A.: J. Exper. Med. 24:683, 1916.Crossref 28. Lambert, R. A., and Meyer, J. R.: Proc. Soc. Exper. Biol. & Med. 23:429, 1926. 29. German, W. J.: Effect of Some Antiseptics on Tissues in Vitro , Arch. Surg. 18:1920 (April, (pt. 2) ) 1929. 30. Buchsbaum, R., and Bloom, W.: Proc. Soc. Exper. Biol. & Med. 28:1060, 1931. 31. Salle, A. J., and Lazarus, A. S.: Proc. Soc. Exper. Biol. & Med. 32:665, 937, 1057, 1119 and 1481, 1935. 32. Salle and Lazarus have recently reported iodine in the form of compound solution of iodine to be more toxic in vitro to bacteria than to tissues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

THE PROBLEM OF WOUND HEALING: I. EFFECT OF LOCAL AGENTS

SMELO, LEON S.
Archives of Surgery , Volume 33 (3) – Sep 1, 1936
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Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1936.01190030146008
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Abstract

Abstract The surgical literature contains reports of the use of numerous topical substances purported to stimulate wound healing. It is my purpose in this article to consider the problem of their evaluation and to present the results obtained in a critical study of certain agents frequently used as wound dressings. HISTORICAL SURVEY The Edwin Smith Surgical Papyrus, the first written record in medical history and perhaps the earliest exegesis of the scientific method in human history, contains a discussion of the principles to be followed in the management of traumatic wounds. During the centuries, knowledge has accrued concerning both the mechanisms of repair and the therapeutics of wounds; yet today these subjects remain in the forefront of surgical thought as problems lacking final solution. The fact that surgeons have yet to attain perfection in the treatment of wounds apparently has constituted a challenge to investigators, judging from the multiplicity of substances References 1. Harvey, S. C.: Proc. Inst. Med. Chicago 10:70, 1934. 2. Carrel, A.: Proc. Inst. Med. Chicago 8:62, 1930. 3. Fisher, A.: Tissue Culture , Copenhagen, Levin & Munksgaard, 1925. 4. Reimann, S. P.: Proliferation of Rat and Mouse Epithelium from Sulphydryl , Protoplasma 10:82 ( (June) ) 1930.Crossref 5. Clark, A. H.: Bull. Johns Hopkins Hosp. 30:117, 1919. 6. Harvey, S. C., and Howes, E. L.: Ann. Surg. 91:641, 1930.Crossref 7. Lohr, W.: Med. Welt 8:1273, 1934. 8. Roegholt, N.: Nederl. tijdschr. v. geneesk. 2:3744, 1929. 9. Bird, C. E., and MacKay, E. M.: Surg., Gynec. & Obst. 54:872, 1932. 10. Rabinowitch, I. M.: Simultaneous Respiratory Exchange and Blood Sugar Time Curves Obtained in Apparently Nondiabetic Patients with Nonhealing Wounds , Arch. Surg. 26:696 ( (April) ) 1933. 11. Sullivan, E. A.: New England J. Med. 209:241, 1933. 12. Kosdoba, A. S.: Arch. f. klin. Chir. 179:435 and 551, 1934. 13. Ciantini, F.: Ann. ital. di chir. 12:1119, 1933. 14. Wheeler, B. C., and Adams, D. S.: New England J. Med. 211:630, 1934. 15. Carrel, A.: Compt. rend. Soc. de biol. 90:333, 1924 16. Hammett, F. S.: Protoplasma 7:297, 1929. 17. Carrel, A., and Hartmann, A.: J. Exper. Med. 24:429, 1916. 18. Du Noüy, P. L.: J. Exper. Med. 24:461 ( (Nov.) ) 1916. 19. Heuer, in Graham, E. A.; Singer, J. J., and Ballon, H. C.: Surgical Diseases of the Chest , Philadelphia, Lea & Febiger, 1935. 20. Brunsting, L. A., and Simonsen, D. G.: Cutaneous Ulcers Treated by Sulphydryl Containing Amino-Acid Cysteine , J. A. M. A. 101:1937 ( (Dec. 16) ) 1933. 21. Birnbaum, I. R.: Ann. Surg. 96:467, 1932. 22. Sutton, L. E.: Thioglycerol: A More Stable Sulphydryl Compound for Use in the Healing of Wounds , J. A. M. A. 104:2168 ( (June 15) ) 1931. 23. Hill, J. H.: The Action of Mercurochrome and Other Drugs on Normal Human Skin and in Infected Wounds , J. A. M. A. 105:100 ( (July 13) ) 1935.Crossref 24. Carrel, A., and Dehelly, G.: Treatment of Infected Wounds , New York, Paul B. Hoeber, Inc., 1916. 25. Wright, A.: Brit. M. J. 2:629, 1915.Crossref 26. The experiments on tissue cultures were performed in the laboratory of Dr. J. M. Hogue. 27. Lambert, R. A.: J. Exper. Med. 24:683, 1916.Crossref 28. Lambert, R. A., and Meyer, J. R.: Proc. Soc. Exper. Biol. & Med. 23:429, 1926. 29. German, W. J.: Effect of Some Antiseptics on Tissues in Vitro , Arch. Surg. 18:1920 (April, (pt. 2) ) 1929. 30. Buchsbaum, R., and Bloom, W.: Proc. Soc. Exper. Biol. & Med. 28:1060, 1931. 31. Salle, A. J., and Lazarus, A. S.: Proc. Soc. Exper. Biol. & Med. 32:665, 937, 1057, 1119 and 1481, 1935. 32. Salle and Lazarus have recently reported iodine in the form of compound solution of iodine to be more toxic in vitro to bacteria than to tissues.

Journal

Archives of Surgery – American Medical Association

Published: Sep 1, 1936

References

  • Tissue Culture
    Fisher , A.
  • Proliferation of Rat and Mouse Epithelium from Sulphydryl
    Reimann , S. P.
  • Simultaneous Respiratory Exchange and Blood Sugar Time Curves Obtained in Apparently Nondiabetic Patients with Nonhealing Wounds
    Rabinowitch , I. M.
  • Surgical Diseases of the Chest
    Heuer , in Graham, E. A.; Singer, J. J., and Ballon, H. C.
  • Cutaneous Ulcers Treated by Sulphydryl Containing Amino-Acid Cysteine
    Brunsting , L. A., and Simonsen, D. G.
  • Thioglycerol: A More Stable Sulphydryl Compound for Use in the Healing of Wounds
    Sutton , L. E.
  • The Action of Mercurochrome and Other Drugs on Normal Human Skin and in Infected Wounds
    Hill , J. H.
  • Treatment of Infected Wounds
    Carrel , A., and Dehelly, G.
  • Effect of Some Antiseptics on Tissues in Vitro
    German , W. J.