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THE PHYSIOLOGIC ACTION OF DIONIN.

THE PHYSIOLOGIC ACTION OF DIONIN. Dionin is ethyl-morphin hydrochlorate, and was discovered by Grimaux (C19 H23 NO3 HCl+H2O). It is a white, odorless, bitter powder, soluble in water, 7 parts; in alcohol, 1.5; in syrup, 20. It is insoluble in ether and chloroform. The aqueous solution is neutral in reaction and keeps a long time. The general physiologic action is similar to that of morphin, but it is claimed that it is less toxic and does not produce nausea, constipation or habit. The respiratory and cardiac centers are unaffected. Applied to the eye, either as a solution or powder, it produces marked sneezing, vasodilation, edema, glandular excitation, burning and lachrymation and supposedly lymphatic extravasation, followed by analgesia, lasting from 2 to 48 hours. Wolffberg1 of Breslau first used it in ophthalmic practice, but it was Darier's2 report that brought it prominently before the profession. The general literature on the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

THE PHYSIOLOGIC ACTION OF DIONIN.

JAMA , Volume XLV (21) – Nov 18, 1905

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Publisher
American Medical Association
Copyright
Copyright © 1905 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1905.52510210032002f
Publisher site
See Article on Publisher Site

Abstract

Dionin is ethyl-morphin hydrochlorate, and was discovered by Grimaux (C19 H23 NO3 HCl+H2O). It is a white, odorless, bitter powder, soluble in water, 7 parts; in alcohol, 1.5; in syrup, 20. It is insoluble in ether and chloroform. The aqueous solution is neutral in reaction and keeps a long time. The general physiologic action is similar to that of morphin, but it is claimed that it is less toxic and does not produce nausea, constipation or habit. The respiratory and cardiac centers are unaffected. Applied to the eye, either as a solution or powder, it produces marked sneezing, vasodilation, edema, glandular excitation, burning and lachrymation and supposedly lymphatic extravasation, followed by analgesia, lasting from 2 to 48 hours. Wolffberg1 of Breslau first used it in ophthalmic practice, but it was Darier's2 report that brought it prominently before the profession. The general literature on the

Journal

JAMAAmerican Medical Association

Published: Nov 18, 1905

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