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The Persisting Pseudomelanoma Problem

The Persisting Pseudomelanoma Problem Abstract • We reviewed 6,169 cases in which whole eyes were submitted to the Armed Forces Institute of Pathology (AFIP), Washington, DC, between January 1970 and December 1980. We sought to determine whether there had been any change in the frequency of incorrect diagnoses of malignant melanoma since two previous studies had been conducted at the AFIP. Of 744 eyes with clear media submitted with the clinical diagnosis of malignant melanoma, the rate of incorrect diagnosis was 6.4% (48 of 744 cases). During the 11-year study, the rate of incorrect diagnoses declined from 12.5% to 1.4%. Despite that overall decrease, the locations and frequency of simulating lesions were comparable with those found in the two previous studies. We believe our current findings reflect a significant increase in diagnostic accuracy among clinicians practicing outside of major academic centers. References 1. Ferry AP: Lesions mistaken for malignant melanoma of the posterior uvea . Arch Ophthalmol 1964;72:463-469.Crossref 2. Shields JA, Zimmerman LE: Lesions simulating malignant melanoma of the posterior uvea . Arch Ophthalmol 1973;89:466-471.Crossref 3. Blodi FC, Roy PE: The misdiagnosed choroidal melanoma . Can J Ophthalmol 1967;2:209-211. 4. Howard GM: Erroneous clinical diagnoses of retinoblastoma and uveal melanoma . Trans Am Acad Ophthalmol Otolaryngol 1968;73:199-203. 5. Shields JA, McDonald PR: Improvements in the diagnosis of posterior uveal melanomas . Arch Ophthalmol 1974;91:259-264.Crossref 6. Robertson DM, Campbell RJ: Errors in the diagnosis of malignant melanoma of the choroid . Am J Ophthalmol 1979;87:269-275. 7. Char DH, Stone RD, Irvine AR, et al: Diagnostic modalities in choroidal melanoma . Am J Ophthalmol 1980;89:223-230. 8. Davidorf FH, Letson AD, Weiss ET, et al: Incidence of misdiagnosed and unsuspected choroidal melanomas: A 50-year experience . Arch Ophthalmol 1983;101:410-412.Crossref 9. Gass DM: Observation of suspected choroidal and ciliary body melanomas for evidence of growth prior to enucleation . Ophthalmology 1980; 87:523-528.Crossref 10. Barr CC, McLean IW, Zimmerman LE: Uveal melanomas in children and adolescents . Arch Ophthalmol 1981;99:2133-2136.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Persisting Pseudomelanoma Problem

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030582024
Publisher site
See Article on Publisher Site

Abstract

Abstract • We reviewed 6,169 cases in which whole eyes were submitted to the Armed Forces Institute of Pathology (AFIP), Washington, DC, between January 1970 and December 1980. We sought to determine whether there had been any change in the frequency of incorrect diagnoses of malignant melanoma since two previous studies had been conducted at the AFIP. Of 744 eyes with clear media submitted with the clinical diagnosis of malignant melanoma, the rate of incorrect diagnosis was 6.4% (48 of 744 cases). During the 11-year study, the rate of incorrect diagnoses declined from 12.5% to 1.4%. Despite that overall decrease, the locations and frequency of simulating lesions were comparable with those found in the two previous studies. We believe our current findings reflect a significant increase in diagnostic accuracy among clinicians practicing outside of major academic centers. References 1. Ferry AP: Lesions mistaken for malignant melanoma of the posterior uvea . Arch Ophthalmol 1964;72:463-469.Crossref 2. Shields JA, Zimmerman LE: Lesions simulating malignant melanoma of the posterior uvea . Arch Ophthalmol 1973;89:466-471.Crossref 3. Blodi FC, Roy PE: The misdiagnosed choroidal melanoma . Can J Ophthalmol 1967;2:209-211. 4. Howard GM: Erroneous clinical diagnoses of retinoblastoma and uveal melanoma . Trans Am Acad Ophthalmol Otolaryngol 1968;73:199-203. 5. Shields JA, McDonald PR: Improvements in the diagnosis of posterior uveal melanomas . Arch Ophthalmol 1974;91:259-264.Crossref 6. Robertson DM, Campbell RJ: Errors in the diagnosis of malignant melanoma of the choroid . Am J Ophthalmol 1979;87:269-275. 7. Char DH, Stone RD, Irvine AR, et al: Diagnostic modalities in choroidal melanoma . Am J Ophthalmol 1980;89:223-230. 8. Davidorf FH, Letson AD, Weiss ET, et al: Incidence of misdiagnosed and unsuspected choroidal melanomas: A 50-year experience . Arch Ophthalmol 1983;101:410-412.Crossref 9. Gass DM: Observation of suspected choroidal and ciliary body melanomas for evidence of growth prior to enucleation . Ophthalmology 1980; 87:523-528.Crossref 10. Barr CC, McLean IW, Zimmerman LE: Uveal melanomas in children and adolescents . Arch Ophthalmol 1981;99:2133-2136.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1984

References