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The Perpetual Challenge of Antimicrobial Resistance

The Perpetual Challenge of Antimicrobial Resistance Opinion VIEWPOINT The emergence of multidrug-resistant bacteria and the A multifaceted, global solution to the problem of an- Anthony S. Fauci, MD rapid global spread of carbapenem-resistant Enterobac- timicrobial resistance is needed, one that combines ef- National Institute of Allergy and Infectious teriaceae (CRE) have recently captured public atten- fective prevention, appropriate use of therapeutics, pas- Diseases, Bethesda, tion, and some have asked whether the ongoing public sive surveillance and active case-finding, and a robust, Maryland. health and scientific “war” against drug-resistant mi- multisector research enterprise for development of crobes,particularlybacteria,caneverbewon.Infact,the drugs and diagnostics, including market-based incen- Hilary D. Marston, MD, MPH challengeofantimicrobialresistanceisanenduringthreat tives for industry. Progress is being made; for example, National Institute of that likely will never be eliminated. The threat is due, in theCentersforDiseaseControlandPreventionlaunched Allergy and Infectious part, to the inherent ability of microbes to replicate rap- the Get Smart campaign to alter prescribing practices for Diseases, Bethesda, idly and mutate, offering them an evolutionary advan- common infectious complaints. The Institute for Health- Maryland. tage in fending off hazards to their survival. Addressing care Improvement has partnered with hospitals to im- the threat of antimicrobial resistance is a never-ending prove protocols for preventing central line–associated challenge. bloodstream http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

The Perpetual Challenge of Antimicrobial Resistance

JAMA , Volume 311 (18) – May 14, 2014

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Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2014.2465
pmid
24652442
Publisher site
See Article on Publisher Site

Abstract

Opinion VIEWPOINT The emergence of multidrug-resistant bacteria and the A multifaceted, global solution to the problem of an- Anthony S. Fauci, MD rapid global spread of carbapenem-resistant Enterobac- timicrobial resistance is needed, one that combines ef- National Institute of Allergy and Infectious teriaceae (CRE) have recently captured public atten- fective prevention, appropriate use of therapeutics, pas- Diseases, Bethesda, tion, and some have asked whether the ongoing public sive surveillance and active case-finding, and a robust, Maryland. health and scientific “war” against drug-resistant mi- multisector research enterprise for development of crobes,particularlybacteria,caneverbewon.Infact,the drugs and diagnostics, including market-based incen- Hilary D. Marston, MD, MPH challengeofantimicrobialresistanceisanenduringthreat tives for industry. Progress is being made; for example, National Institute of that likely will never be eliminated. The threat is due, in theCentersforDiseaseControlandPreventionlaunched Allergy and Infectious part, to the inherent ability of microbes to replicate rap- the Get Smart campaign to alter prescribing practices for Diseases, Bethesda, idly and mutate, offering them an evolutionary advan- common infectious complaints. The Institute for Health- Maryland. tage in fending off hazards to their survival. Addressing care Improvement has partnered with hospitals to im- the threat of antimicrobial resistance is a never-ending prove protocols for preventing central line–associated challenge. bloodstream

Journal

JAMAAmerican Medical Association

Published: May 14, 2014

References