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The Peril of the Pilot Study

The Peril of the Pilot Study Abstract As Dr Bressler and his colleagues1 point out, much is yet to be learned about the prognosis of patients with age-related macular degeneration who have poorly demarcated or "occult" choroidal neovascularization (CNV). Their 2-year follow-up of 100 patients with this condition provides new and important information about the natural history of the disease. Although previous publications have suggested a more benign prognosis for these patients than for those with "classic" CNV,2-4 patients in this study had a higher rate of visual loss than previously suspected. For patients meeting this study's eligibility criteria, the 1-year risk of losing 6 lines of visual acuity (a quadrupling of the initial visual angle) was about 40% for treated or untreated eyes. This is about the same rate of loss of visual acuity that was documented by the Macular Photocoagulation Study (MPS) Group in untreated eyes with newly developed subfoveal CNV.5 More References 1. Bressler NM, Maguire MG, Murphy PL, et al. Macular scatter ('grid') laser treatment of poorly demarcated subfoveal choroidal neovascularization in agerelated macular degeneration: results of a randomized pilot trial . Arch Ophthalmol . 1996;114:1456-1464.Crossref 2. Bressler NM, Frost L, Bressler SB, Fine SL. Natural course of poorly defined choroidal neovascularization in macular degeneration . Arch Ophthalmol . 1988;106:1537-1542.Crossref 3. Soubrane G, Coscas G, Francais C, Koenig F. Occult subretinal new vessels in age-related macular degeneration: natural history and early laser treatment . Ophthalmology . 1990;97:649-657.Crossref 4. Macular Photocoagulation Study Group. Occult choroidal neovascularization: influence on visual outcome in patients with age-related macular degeneration . Arch Ophthalmol . 1996;114:400-412.Crossref 5. Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal neovascular lesions of age-related macular degeneration: updated findings from two clinical trials . Arch Ophthalmol . 1993;111:1200-1209.Crossref 6. Angioletti IV, Colquhoun PJ, Kulik AD, Malpica EH. Indirect photocoagulation of subfoveal choroidal neovascularization in age-related macular degeneration . Bull N Y Acad Med . 1991;67:4. 7. Tornambe PE, Poliner LS, Hovey LJ, Taren D. Scatter macular photocoagulation for subfoveal neovascular membranes in age-related macular degeneration: a pilot study . Retina . 1992;12:305-314.Crossref 8. Yassur Y, Rosenblatt I, Loewenstein A. Grid laser photocoagulation on decompensated retinal pigment epithelium: adjunct treatment of choroidal neovascularization . Middle Eastern J Ophthalmol . 1995;3:77-83. 9. Buzney SM, Weiter JJ, Freilich BD. Scatter macular photocoagulation for age-related subfoveal neovascularization . In: Investigative Ophthalmology & Visual Science Abstract Book ; May 14-19, 1995; Fort Lauderdale, Fla. Abstract 1027. 10. Midena E, Valenti M, Piermarocchi S, Bertoja E, Degli Argeli C, Segato T. Functional effects of scatter macular photocoagulation for age-related subfoveal neovascularization . Investigative Ophthalmology & Visual Science Abstract Book ; April 21-26, 1996; Fort Lauderdale, Fla. Abstract 526-B438. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1996.01100140704011
Publisher site
See Article on Publisher Site

Abstract

Abstract As Dr Bressler and his colleagues1 point out, much is yet to be learned about the prognosis of patients with age-related macular degeneration who have poorly demarcated or "occult" choroidal neovascularization (CNV). Their 2-year follow-up of 100 patients with this condition provides new and important information about the natural history of the disease. Although previous publications have suggested a more benign prognosis for these patients than for those with "classic" CNV,2-4 patients in this study had a higher rate of visual loss than previously suspected. For patients meeting this study's eligibility criteria, the 1-year risk of losing 6 lines of visual acuity (a quadrupling of the initial visual angle) was about 40% for treated or untreated eyes. This is about the same rate of loss of visual acuity that was documented by the Macular Photocoagulation Study (MPS) Group in untreated eyes with newly developed subfoveal CNV.5 More References 1. Bressler NM, Maguire MG, Murphy PL, et al. Macular scatter ('grid') laser treatment of poorly demarcated subfoveal choroidal neovascularization in agerelated macular degeneration: results of a randomized pilot trial . Arch Ophthalmol . 1996;114:1456-1464.Crossref 2. Bressler NM, Frost L, Bressler SB, Fine SL. Natural course of poorly defined choroidal neovascularization in macular degeneration . Arch Ophthalmol . 1988;106:1537-1542.Crossref 3. Soubrane G, Coscas G, Francais C, Koenig F. Occult subretinal new vessels in age-related macular degeneration: natural history and early laser treatment . Ophthalmology . 1990;97:649-657.Crossref 4. Macular Photocoagulation Study Group. Occult choroidal neovascularization: influence on visual outcome in patients with age-related macular degeneration . Arch Ophthalmol . 1996;114:400-412.Crossref 5. Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal neovascular lesions of age-related macular degeneration: updated findings from two clinical trials . Arch Ophthalmol . 1993;111:1200-1209.Crossref 6. Angioletti IV, Colquhoun PJ, Kulik AD, Malpica EH. Indirect photocoagulation of subfoveal choroidal neovascularization in age-related macular degeneration . Bull N Y Acad Med . 1991;67:4. 7. Tornambe PE, Poliner LS, Hovey LJ, Taren D. Scatter macular photocoagulation for subfoveal neovascular membranes in age-related macular degeneration: a pilot study . Retina . 1992;12:305-314.Crossref 8. Yassur Y, Rosenblatt I, Loewenstein A. Grid laser photocoagulation on decompensated retinal pigment epithelium: adjunct treatment of choroidal neovascularization . Middle Eastern J Ophthalmol . 1995;3:77-83. 9. Buzney SM, Weiter JJ, Freilich BD. Scatter macular photocoagulation for age-related subfoveal neovascularization . In: Investigative Ophthalmology & Visual Science Abstract Book ; May 14-19, 1995; Fort Lauderdale, Fla. Abstract 1027. 10. Midena E, Valenti M, Piermarocchi S, Bertoja E, Degli Argeli C, Segato T. Functional effects of scatter macular photocoagulation for age-related subfoveal neovascularization . Investigative Ophthalmology & Visual Science Abstract Book ; April 21-26, 1996; Fort Lauderdale, Fla. Abstract 526-B438.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1996

References