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H. Gerstein, Michael Miller, R. Byington, D. Goff, J. Bigger, J. Buse, W. Cushman, S. Genuth, F. Ismail-Beigi, R. Grimm, J. Probstfield, D. Simons-Morton, W. Friedewald (2008)
Effects of intensive glucose lowering in type 2 diabetes.The New England journal of medicine, 358 24
The A1C Test and Diabetes: NIH publication 11-7816. September 2011.
S. Kirsh, D. Aron (2011)
Choosing Targets for Glycaemia, Blood Pressure and Low-Density Lipoprotein Cholesterol in Elderly Individuals with Diabetes MellitusDrugs & Aging, 28
F. Ismail-Beigi, E. Moghissi, M. Tiktin, I. Hirsch, S. Inzucchi, S. Genuth (2011)
Individualizing Glycemic Targets in Type 2 Diabetes Mellitus: Implications of Recent Clinical TrialsAnnals of Internal Medicine, 154
A Holstein, OM Patzer, K Machalke, JD Holstein, M Stumvoll, P Kovacs (2012)
Substantial increase in incidence of severe hypoglycemia between 1997-2000 and 2007-2010: a German longitudinal population-based study., 35
R. Turner, R. Holman, I. Stratton, C. Cull, D. Matthews, S. Manley, V. Frighi, D. Wright, A. Neil, E. Kohner, H. Mcelroy, C. Fox, D. Hadden, Grp Ukpds. (1998)
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)The Lancet, 352
A. Holstein, O. Patzer, K. Machalke, Judith Holstein, M. Stumvoll, P. Kovacs (2012)
Substantial Increase in Incidence of Severe Hypoglycemia Between 1997–2000 and 2007–2010Diabetes Care, 35
W. Duckworth, C. Abraira, Thomas Moritz, D. Reda, N. Emanuele, P. Reaven, F. Zieve, J. Marks, S. Davis, R. Hayward, S. Warren, S. Goldman, M. Mccarren, Mary Vitek, W. Henderson, Grant Huang (2009)
Glucose control and vascular complications in veterans with type 2 diabetes.The New England journal of medicine, 360 2
L. Pogach, D. Aron (2011)
Sudden acceleration of diabetes quality measures.JAMA, 305 7
H. Gerstein, Michael Miller, R. Byington (2010)
ACTION TO CONTROL CARDIOVASCULAR RISK IN DIABETES STUDY GROUP. EFFECTS OF INTENSIVE GLUCOSE LOWERING IN TYPE 2 DIABETES, 33
T. Moore, Michael Cohen, C. Furberg
Confidential. Do Not Distribute. Pre-embargo Material. Serious Adverse Drug Events Reported to the Food and Drug Administration, 1998-2005
Anushka Patel, S. MacMahon, J. Chalmers, B. Neal, L. Billot, M. Woodward, M. Marre, M. Cooper, P. Glasziou, D. Grobbee, P. Hamet, S. Harrap, S. Heller, Li-sheng Liu, G. Mancia, C. Mogensen, C. Pan, N. Poulter, A. Rodgers, B. Williams, Severine Bompoint, B. Galan, R. Joshi, F. Travert (2008)
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.The New England journal of medicine, 358 24
Diabetes Control, D. Nathan, S. Genuth, J. Lachin, P. Cleary, O. Crofford, M. Davis, L. Rand, C. Siebert (1993)
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long‐Term Complications in Insulin‐Dependent Diabetes MellitusSurvey of Anesthesiology, 38
V. Montori, Merc Fernndez-Balsells (2009)
Glycemic Control in Type 2 Diabetes: Time for an Evidence-Based About-Face?Annals of Internal Medicine, 150
(1998)
The Diabetes Control and Complications TrialInpharma Weekly, 1120
Uk-Prospective-Diabetes-Study-Group (1998)
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 352
R. Little, C. Rohlfing, D. Sacks (2011)
Status of hemoglobin A1c measurement and goals for improvement: from chaos to order for improving diabetes care.Clinical chemistry, 57 2
(2012)
American Medical Association. All rights reserved
R. Turner, C. Fox, Matthews, H. Mcelroy, C. Cull, R. Holman, P. Neil, D. Hadden, D. Wright, É. Manley, I. Stratton, Uk Diabetes, E. Kohner, Frighi, Michael Gnant (1998)
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.The Lancet
TJ Moore, MR Cohen, CD Furberg (2007)
Serious adverse drug events reported to the Food and Drug Administration, 1998-2005., 167
(2011)
US Department of Health and Human Services website
OCT 22, 2012 WWW.ARCHINTERNMED.COM 1511
D. Budnitz, M. Lovegrove, Nadine Shehab, C. Richards (2011)
Emergency hospitalizations for adverse drug events in older Americans.The New England journal of medicine, 365 21
COMMENTARY LESS IS MORE The Other Side of Quality Improvement in Diabetes for Seniors A Proposal for an Overtreatment Glycemic Measure HE MANAGEMENT OF demonstrated that there was no car- trends of severe hypoglycemia in the diabetes poses chal- diovascular benefit associated with United States is not known, al- lenges at all levels, tight control of glycemia (achieved though a population study from Ger- from affected indi- hemoglobin A of 6.4%, 6.4%, and many found a substantial increase 1c T viduals to society as 6.9% for ACCORD, ADVANCE, and between 1997-2000 and 2007- a whole. Microvascular complica- VADT, respectively) compared with 2010. Also, comorbid medical and tions of diabetes have been attrib- control arms (7.5%, 7.0%, and 8.4% mental health conditions that could uted to poor glycemic control since for ACCORD, ADVANCE, and affect the risk of hypoglycemia are the Joslin era. This hypothesis was VADT, respectively). In fact, highly prevalent among persons confirmed for patients with type 1 ACCORD was stopped prematurely older than 65 years. diabetes mellitus by the results of the because of increased mortality in the Another factor is also altering the Diabetes Control and Complica- intensive control group, an increase landscape: increasing recognition tions
JAMA Internal Medicine – American Medical Association
Published: Oct 22, 2012
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