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THE ORAL ADMINISTRATION OF EPINEPHRINE

THE ORAL ADMINISTRATION OF EPINEPHRINE Abstract As a result of many clinical and experimental investigations, current opinion regards epinephrine as producing little if any effect when administrated orally. Sollmann1 states that "it is entirely ineffective by oral administration" and that "the blood pressure response is practically absent" when given by mouth. In "Useful Drugs"2 it is stated that, "when given by mouth, it produces no evident effect on the general circulation." Cushny3 states that "when given by mouth, it has no effect on the blood pressure or heart." According to an article in the "Pharmacology of Useful Drugs,"4 "epinephrine is one of the few alkaloids in the materia medica which are not absorbed from the gastrointestinal canal with such rapidity as to induce any appreciable effect." In the recent series of articles on glandular therapy in The Journal of the American Medical Association, it was stated,5 regarding epinephrine, that "when the drug is administered by mouth, References 1. Sollmann, Torald: A Manual of Pharmacology and Its Application to Therapeutics and Toxicology , ed. 2, Philadelphia, W. B. Saunders Company, 1922, pp. 385, 387. 2. Useful Drugs, Prepared Under the Direction and Supervision of the Council on Pharmacy and Chemistry of the American Medical Association, ed. 6, 1923, p. 70. 3. Cushny, A. R.: A Textbook of Pharmacology and Therapeutics, or the Action of Drugs in Health and Disease , ed. 7, Philadelphia, Lea & Febiger, 1918, p. 374. 4. Hatcher, R. A., and Wilbert, M. I.: Pharmacology of Useful Drugs , Chicago, American Medical Association, 1915, p. 189. 5. Wearn, J. T.: Glandular Therapy: Pharmacology of Epinephrine , J. A. M. A. 83: 1508 ( (Nov. 8) ) 1924.Crossref 6. Herter, C. A., and Wakeman, A. J.: On Adrenalin Glycosuria and Allied Forms of Experimental Glycosuria Due to the Action of Reducing Substances and Other Poisons on the Cells of the Pancreas , Tr. A. Am. Phys. 17:570, 1902. 7. Falta, W., and Ivcović, L.: Ueber die Wirkungsweise des Adrenalins bei verscheidener Applikation und das Auftreten desselben im Harn , Wien. klin. Wchnschr. 22:1780, 1909. 8. Dorlencourt, H.; Trias, A., and Paychère, A.: Stabilisation du faux de la glycémie chez le chien durant le sommeil chloralosique , Compt. rend. Soc. de biol. 86:1078, 1922 9. Absorption de l'adrenaline par voie digestive , Dorlencourt Compt. rend. Soc. de biol. 86:1129, 1922. 10. Rogers, J.: Adrenal Feeding in Conditions of Hyperthyroidism , Endocrinology 6:73 ( (Jan.) ) 1922.Crossref 11. Aschner, B., and Pisk, H.: Ist das Adrenalin vom Magendarmtrakt aus Wirksam? Klin. Wchnschr. 3:1265 ( (July 8) ) 1924.Crossref 12. Trias, A., and Dorlencourt, H.: How Adrenalin Should Be Given , J. des Practiciens , (Feb.) 10, 1923 13. Practitioner 110:333 ( (April) ) 1923. 14. Brems, A.: Ueber die perorale Adrenalinwirkung , Acta med. Scandinav. 63:431 ( (May 27) ) 1926.Crossref 15. Weiss, S., and Baitz, G.: Zur Frage der Wirkung des stomachal verabreichten Adrenalins , Ztschr. f. d. ges. exper. Med. 49:543, 1926.Crossref 16. Hepner and Cervenka, quoted by Weiss and Baitz (footnote 13). 17. Hitchcock, F. A.: The Effect of Ingested Adrenalin Chloride on Basal Metabolism , Am. J. Physiol. 69:271, 1924. 18. Harrower, H. R.: Oral Administration of Adenalin , New Yok M. J. 104: 893 ( (Nov. 4) ) 1916. 19. Satterthwaite, T. E.: Drug Therapy in Cardiovascular Diseases , Internat. Clin. 1:26, 1916. 20. Milian, G.: L'administration de l'adrenaline , Paris méd 8:81 ( (Feb. 2) ) 1918. 21. Hoxie, G. H., and Morris, H. T.: Adrenalin in Asthma. A Case of Chronic Adrenalism , Endocrinology 4:47, 1920.Crossref 22. Alvarado, R., and Arroyabe, V.: Treatment of Vomiting in Malaria , Prensa méd. argent. 13:242, 1926 23. J. A. M. A. 87:1690 ( (Nov. 13) ) 1926. 24. Heinekamp, W. J. R.: The Sthenic Action of Adrenalin on the Intestines , J. Lab. & Clin. Med. 11:1062 ( (Aug.) ) 1926. 25. Menninger, W. C., and Heim, H. S.: The Rectal Administration of Epinephrin , Am. J. M. Sc. 172:425 ( (Sept.) ) 1926. 26. Muirhead, A. L.: An Autograph History of a Case of Addison's Disease , J. A. M. A. 76:651 ( (March 5) ) 1921. 27. Daniélopolu, D.: Substances Acting on the Vegetative Nervous System , Paris méd. 33:657 ( (May 20) ) 1925. 28. Katsch: Fortschr. a. d. Geb. d. Röntgenstrahlen. 21:159, 1913. 29. Dickson, W. H., and Wilson, M. J.: The Control of the Motility of the Human Stomach by Drugs and Other Means , J. Pharmacol. & Exper. Therap. 24:33, 1924-1925. 30. Daniélopolu, D., and Carniol, A.: Action de l'adrénaline sur l'estomac de l'homme. Voie intraveineuse et voie gastrique , Compt. rend. Soc. de biol. 87:716, 1922. 31. Grünbaum, O. F. F.: Suprarenal Gland Extract as a Hemostatic , Brit. M. J. 2:1307, 1900. 32. Falta and Turin: in Falta, W.: Endocrine Diseases , trans. by M. K. Meyers, ed. 3, Philadelphia, P. Blakiston's Son & Company, 1923, p. 361. 33. Wiggers, C. J.: The Effect of Adrenalin on Intestinal Hemorrhage , Arch. Int. Med. 3:139 ( (March) ) 1909. 34. Yukawa: Klinischexperimentelle Untersuchungen der Adrenalin Wirkung auf die Magendrusen , Arch. f. Verdauungskr. 14:166, 1908. 35. Loeper and Verpy: L'action de l'adrenaline sur le tractus digestif , Soc. de Biol. , (July) 28, 1917 36. Hernando: Presse méd. 31:797 ( (Sept. 19) ) 1923. 37. Binet, L.: L'action de l'adrenalin sur le tube gastro-intestinal , Presse méd. 26:407, 1918. 38. Rogers, J.; Rahe, J. M., and Ablahadian, E.: The Stimulation and Inhibition of the Gastric Secretion Which Follows the Subcutaneous Administration of Certain Organ Extracts , Am. J. Physiol. 48:79, 1919. 39. Boenheim: Ueber den Einfluss von Blutdrusen-Extrakten auf die Magensekretion , Arch. f. Verdauungskr. 26:74, 1920. 40. Hess and Gundlach: Der Einfluss des Adrenalins auf die Sekretion des Magensaftes , Arch. f. d. ges. Physiol. 185:122, 1920. 41. Hernando, T.: Action de quelques medicaments sur la secrétion gastrique , Presse méd. 31:797 ( (Sept. 19) ) 1923. 42. Moore, B., quoted from Sollman, 1895, p. 335. 43. Wearn (footnote 5) 44. Satterthwaite (footnote 17). 45. Lesne, E. De l'administration de l'adrenaline par le voie digestive , Bull. et mém. Soc. méd. d. hôp. de Paris 44:800, 1920. 46. Gioffredi, C.: La distruzione dell adrenalina nell' organismo , Arch. di farmacol. sper. 6:607, 1907. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE ORAL ADMINISTRATION OF EPINEPHRINE

Archives of Internal Medicine , Volume 40 (5) – Nov 1, 1927

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American Medical Association
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Copyright © 1927 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1927.00130110131012
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Abstract

Abstract As a result of many clinical and experimental investigations, current opinion regards epinephrine as producing little if any effect when administrated orally. Sollmann1 states that "it is entirely ineffective by oral administration" and that "the blood pressure response is practically absent" when given by mouth. In "Useful Drugs"2 it is stated that, "when given by mouth, it produces no evident effect on the general circulation." Cushny3 states that "when given by mouth, it has no effect on the blood pressure or heart." According to an article in the "Pharmacology of Useful Drugs,"4 "epinephrine is one of the few alkaloids in the materia medica which are not absorbed from the gastrointestinal canal with such rapidity as to induce any appreciable effect." In the recent series of articles on glandular therapy in The Journal of the American Medical Association, it was stated,5 regarding epinephrine, that "when the drug is administered by mouth, References 1. Sollmann, Torald: A Manual of Pharmacology and Its Application to Therapeutics and Toxicology , ed. 2, Philadelphia, W. B. Saunders Company, 1922, pp. 385, 387. 2. Useful Drugs, Prepared Under the Direction and Supervision of the Council on Pharmacy and Chemistry of the American Medical Association, ed. 6, 1923, p. 70. 3. Cushny, A. R.: A Textbook of Pharmacology and Therapeutics, or the Action of Drugs in Health and Disease , ed. 7, Philadelphia, Lea & Febiger, 1918, p. 374. 4. Hatcher, R. A., and Wilbert, M. I.: Pharmacology of Useful Drugs , Chicago, American Medical Association, 1915, p. 189. 5. Wearn, J. T.: Glandular Therapy: Pharmacology of Epinephrine , J. A. M. A. 83: 1508 ( (Nov. 8) ) 1924.Crossref 6. Herter, C. A., and Wakeman, A. J.: On Adrenalin Glycosuria and Allied Forms of Experimental Glycosuria Due to the Action of Reducing Substances and Other Poisons on the Cells of the Pancreas , Tr. A. Am. Phys. 17:570, 1902. 7. Falta, W., and Ivcović, L.: Ueber die Wirkungsweise des Adrenalins bei verscheidener Applikation und das Auftreten desselben im Harn , Wien. klin. Wchnschr. 22:1780, 1909. 8. Dorlencourt, H.; Trias, A., and Paychère, A.: Stabilisation du faux de la glycémie chez le chien durant le sommeil chloralosique , Compt. rend. Soc. de biol. 86:1078, 1922 9. Absorption de l'adrenaline par voie digestive , Dorlencourt Compt. rend. Soc. de biol. 86:1129, 1922. 10. Rogers, J.: Adrenal Feeding in Conditions of Hyperthyroidism , Endocrinology 6:73 ( (Jan.) ) 1922.Crossref 11. Aschner, B., and Pisk, H.: Ist das Adrenalin vom Magendarmtrakt aus Wirksam? Klin. Wchnschr. 3:1265 ( (July 8) ) 1924.Crossref 12. Trias, A., and Dorlencourt, H.: How Adrenalin Should Be Given , J. des Practiciens , (Feb.) 10, 1923 13. Practitioner 110:333 ( (April) ) 1923. 14. Brems, A.: Ueber die perorale Adrenalinwirkung , Acta med. Scandinav. 63:431 ( (May 27) ) 1926.Crossref 15. Weiss, S., and Baitz, G.: Zur Frage der Wirkung des stomachal verabreichten Adrenalins , Ztschr. f. d. ges. exper. Med. 49:543, 1926.Crossref 16. Hepner and Cervenka, quoted by Weiss and Baitz (footnote 13). 17. Hitchcock, F. A.: The Effect of Ingested Adrenalin Chloride on Basal Metabolism , Am. J. Physiol. 69:271, 1924. 18. Harrower, H. R.: Oral Administration of Adenalin , New Yok M. J. 104: 893 ( (Nov. 4) ) 1916. 19. Satterthwaite, T. E.: Drug Therapy in Cardiovascular Diseases , Internat. Clin. 1:26, 1916. 20. Milian, G.: L'administration de l'adrenaline , Paris méd 8:81 ( (Feb. 2) ) 1918. 21. Hoxie, G. H., and Morris, H. T.: Adrenalin in Asthma. A Case of Chronic Adrenalism , Endocrinology 4:47, 1920.Crossref 22. Alvarado, R., and Arroyabe, V.: Treatment of Vomiting in Malaria , Prensa méd. argent. 13:242, 1926 23. J. A. M. A. 87:1690 ( (Nov. 13) ) 1926. 24. Heinekamp, W. J. R.: The Sthenic Action of Adrenalin on the Intestines , J. Lab. & Clin. Med. 11:1062 ( (Aug.) ) 1926. 25. Menninger, W. C., and Heim, H. S.: The Rectal Administration of Epinephrin , Am. J. M. Sc. 172:425 ( (Sept.) ) 1926. 26. Muirhead, A. L.: An Autograph History of a Case of Addison's Disease , J. A. M. A. 76:651 ( (March 5) ) 1921. 27. Daniélopolu, D.: Substances Acting on the Vegetative Nervous System , Paris méd. 33:657 ( (May 20) ) 1925. 28. Katsch: Fortschr. a. d. Geb. d. Röntgenstrahlen. 21:159, 1913. 29. Dickson, W. H., and Wilson, M. J.: The Control of the Motility of the Human Stomach by Drugs and Other Means , J. Pharmacol. & Exper. Therap. 24:33, 1924-1925. 30. Daniélopolu, D., and Carniol, A.: Action de l'adrénaline sur l'estomac de l'homme. Voie intraveineuse et voie gastrique , Compt. rend. Soc. de biol. 87:716, 1922. 31. Grünbaum, O. F. F.: Suprarenal Gland Extract as a Hemostatic , Brit. M. J. 2:1307, 1900. 32. Falta and Turin: in Falta, W.: Endocrine Diseases , trans. by M. K. Meyers, ed. 3, Philadelphia, P. Blakiston's Son & Company, 1923, p. 361. 33. Wiggers, C. J.: The Effect of Adrenalin on Intestinal Hemorrhage , Arch. Int. Med. 3:139 ( (March) ) 1909. 34. Yukawa: Klinischexperimentelle Untersuchungen der Adrenalin Wirkung auf die Magendrusen , Arch. f. Verdauungskr. 14:166, 1908. 35. Loeper and Verpy: L'action de l'adrenaline sur le tractus digestif , Soc. de Biol. , (July) 28, 1917 36. Hernando: Presse méd. 31:797 ( (Sept. 19) ) 1923. 37. Binet, L.: L'action de l'adrenalin sur le tube gastro-intestinal , Presse méd. 26:407, 1918. 38. Rogers, J.; Rahe, J. M., and Ablahadian, E.: The Stimulation and Inhibition of the Gastric Secretion Which Follows the Subcutaneous Administration of Certain Organ Extracts , Am. J. Physiol. 48:79, 1919. 39. Boenheim: Ueber den Einfluss von Blutdrusen-Extrakten auf die Magensekretion , Arch. f. Verdauungskr. 26:74, 1920. 40. Hess and Gundlach: Der Einfluss des Adrenalins auf die Sekretion des Magensaftes , Arch. f. d. ges. Physiol. 185:122, 1920. 41. Hernando, T.: Action de quelques medicaments sur la secrétion gastrique , Presse méd. 31:797 ( (Sept. 19) ) 1923. 42. Moore, B., quoted from Sollman, 1895, p. 335. 43. Wearn (footnote 5) 44. Satterthwaite (footnote 17). 45. Lesne, E. De l'administration de l'adrenaline par le voie digestive , Bull. et mém. Soc. méd. d. hôp. de Paris 44:800, 1920. 46. Gioffredi, C.: La distruzione dell adrenalina nell' organismo , Arch. di farmacol. sper. 6:607, 1907.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1927

References