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The Ocular Manifestations of Waldenström's Macroglobulinemia and Its Treatment

The Ocular Manifestations of Waldenström's Macroglobulinemia and Its Treatment Abstract Macroglobulinemia is a disease of the reticuloendothelial system in which the signs and symptoms are associated with an abnormal protein having a high molecular weight. The ocular complications in this disease are being reported with increasing frequency with the spectrum of retinal changes ranging from slight dilatation and fullness of veins, hemorrhages, and exudates to occlusion of the central vein, retinal edema, and exudative retinal detachment. Externally, segmentation and clumping of the red blood cells within conjunctival vessels may be seen. In reviews of the literature, the incidence of retinopathy ranges from 30% to 67%.1,2 Cagianut3 reported 13 of 20 patients were severely incapacitated because of visual impairment. The ocular findings were first emphasized by Waldenström4 in his original report in 1944. Of 3 cases, the initial complaint in one patient was loss of vision due to a central vein occlusion, and the second had prominent dilated References 1. Logothetis, J.; Silverstein, P., and Coe, J.: Neurologic Aspects of Waldenström's Macroglobulinemia , Arch. Neurol. 3:564, 1960.Crossref 2. Schur, P. H., and Appel, L.: Waldenström's Macroglobulinemia with Pleural Effusion , New York J. Med. 61:2431, 1961. 3. Cagianut, B.: Ocular Syndrome of Macroglobulinemia , Ann. Oculist. (Par.) 191:579, 1958. 4. Waldenström, J.: Incipient Myelomatosis with "Essential" Hyperglobulinemia and Fibrinogenopenia: A New Syndrome? Acta Med. Scand. 117:216, 1944.Crossref 5. Waldenström, J.: Abnormal Proteins in Myeloma , Advance. Intern. Med. 5:398, 1952. 6. Willi, H.; Koller, F., and Raaflaub, J.: Symptomatische makroglobulinämie bei Lues congenita: Beitrag zur Frage der Fibrinasthenie Fanconi , Acta Haemat. (Basel) 11:316, 1954.Crossref 7. Wuhrmann, F.: Einige aktuelle klinische Probleme über die Serum-Globuline , Schweiz. Med. Wschr. 82:937, 1952. 8. Habich, H.: Zur Antigenanalyse der Paraproteine bei Makroglobulinämien , Schweiz. Med. Wschr. 83:1957, 1953. 9. Habich, H., and Hässig, A.: Essai d'analyse antigénique des paraprotides dans la macroglobulinémie du Waldenström , Vox Sang. 3:98, 1953. 10. Kanzow, U.; Scholtan, W., and Mütang, A.: Serologische Differenzierung von Makroglobulinämien , Klin. Wschr. 33:1043, 1955.Crossref 11. Sia, R. H. P.: Simple Method for Estimating Quantitative Differences in Kala-Azar , Chin. Med. J. 38:35, 1924. 12. Martin, N. H.: Macroglobulinaemia , Quart. J. Med. 29:179, 1960. 13. Wuhrmann, F.: Makroglobulinämie mit Stimmbandkarzinom , Helv. Med. Acta 24:268, 1957. 14. Schaub, F.: Gleichzeitiges Vorkommen von Makroglobulinämie Waldenström und von malignen Tumoren , Schweiz. Med. Wschr. 83:1256, 1953. 15. Waldenström, J.: Macroglobulinemia , Acta Haemat. (Basel) 20:33, 1958.Crossref 16. Laurell, C. B.; Laurell, H., and Waldenström, J.: Glycoproteins in Serum from Patients with Myeloma, Macroglobulinemia and Related Conditions , Amer. J. Med. 22:24, 1957.Crossref 17. Spalter, H. F.: Abnormal Serum Proteins and Retinal Vein Thrombosis , A.M.A. Arch. Ophthal. 62:868, 1959.Crossref 18. Cagianut, B., and Theiler, K.: Histology of Ocular Changes in Macroglobulinemia , Graefe. Arch. Ophth. 160:628, 1959.Crossref 19. Dutcher, T. F., and Fahey, J. L.: The Histopathology of the Macroglobulinemia of Waldenström , J. Nat. Cancer Inst. 22:887, 1959. 20. Pitney, W. R.; O'Sullivan, W. J., and Owen, J. A.: Effect of Prednisolone on Anemia Associated with Macroglobulinemia , Brit. Med. J. 2:1508, 1958.Crossref 21. Mackay, I. R.; Eriksen, N.; Motulsky, A. G., and Volwiler, W.: Cryo- and Macroglobulinemia , Amer. J. Med. 20:564, 1956.Crossref 22. Lawson, H. A.; Stuart, C. A.; Paull, A. M.; Phillips, A. M., and Phillips, R. W.: Observations on the Antibody Content of the Blood in Patients with Multiple Myeloma , New Engl. J. Med. 252:13, 1955.Crossref 23. Pachter, M. R.; Johnson, S. A.; Neblett, T. R., and Truant, J. P.: Bleeding, Platelets, and Macroglobulinemia , Amer. J. Clin. Path. 31: 467, 1959. 24. Macroglobulinemia, Clinicopathological Conference , Amer. J. Med. 28:951, 1960.Crossref 25. Deutsch, H. F., and Morton, J. I.: Dissociation of Human Serum Macroglobulins , Science 125:600, 1957.Crossref 26. Abraham, E. P.; Chain, E.; Baker, W., and Robinson, R.: Penicillamine, a Characteristic Degradation Product of Penicillin , Nature (Lond.) 151:107, 1943.Crossref 27. Walshe, J. M.: Penicillamine: A New Oral Therapy for Wilson's Disease , Amer. J. Med. 21:487, 1956.Crossref 28. Bloch, H. S.; Prasad, A., and Anastasi, A.: Serum Protein Changes in Waldenström's Macroglobulinemia During Penicillamine Administration , J. Lab. Clin. Med. 52:793, 1958. 29. Ritzmann, S. E.; Coleman, S. L., and Levin, W. C.: The Effect of Some Mercaptanes upon a Macrocryogelglobulin: Modifications Induced by Cysteamine, Penicillamine and Penicillin , J. Clin. Invest. 39:1320, 1960.Crossref 30. Levine, M. A.; Hammack, W. J., and Frommeyer, W. B.: Treatment of Macroglobulinemia with Penicillamine , Clin. Res. 8:54, 1960. 31. Strong, J. B., Jr.; Dempsey, H., and Hill, S. R., Jr.: The Successful Management of Hepatolenticular Degeneration with Penicillamine , Ann. Intern. Med. 54:198, 1961.Crossref 32. Scheinberg, I. H., and Sternlieb, I.: Penicillamine as the Basis of Therapy in Wilson's Disease , in Metal-Binding in Medicine , edited by M. J. Seven and L. A. Johnson, Philadelphia, J. B. Lippincott Company, 1960, p. 275. 33. Wilson, J. E., and DuVigneaud, V.: Inhibition of the Growth of the Rat by L-Penicillamine and Its Prevention by Aminoethanol and Its Related Compounds , J. Biol. Chem. 184:63, 1950. 34. Kuchinskas, E. J.; Horvath, A., and DuVigneaud, V.: An Anti-Vitamin B6 Action of L-Penicillamine , Arch. Biochem. 68:69, 1957.Crossref 35. DuVigneaud, V.; Kuchinskas, E. J., and Horvath, A.: L-Penicillamine and Rat Liver Transaminase Activity , Arch. Biochem. 69:130, 1957.Crossref 36. Aposhian, H. V., in Metal Binding in Medicine , edited by M. J. Seven and L. A. Johnson, Philadelphia, J. B. Lippincott Company, 1960, p. 304. 37. Schwab, P. J.; Okun, E., and Fahey, J. L.: Reversal of Retinopathy in Waldenström's Macroglobulinemia by Plasmapheresis , Arch. Ophthal. 64:515, 1960.Crossref 38. Coyle, J. T.; Frank, P. E.; Leonard, A. L., and Weiner, A.: Macroglobulinemia and Its Effect upon the Eye , Arch. Ophthal. 65:75, 1961.Crossref 39. Skoog, W. A., and Adams, W. S.: Plasmapheresis in a Case of Waldenström's Macroglobulinemia , Clin. Res. 7:96, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Ocular Manifestations of Waldenström's Macroglobulinemia and Its Treatment

ACKERMAN, ALBERT L.
Archives of Ophthalmology , Volume 67 (6) – Jun 1, 1962
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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960020701002
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Abstract

Abstract Macroglobulinemia is a disease of the reticuloendothelial system in which the signs and symptoms are associated with an abnormal protein having a high molecular weight. The ocular complications in this disease are being reported with increasing frequency with the spectrum of retinal changes ranging from slight dilatation and fullness of veins, hemorrhages, and exudates to occlusion of the central vein, retinal edema, and exudative retinal detachment. Externally, segmentation and clumping of the red blood cells within conjunctival vessels may be seen. In reviews of the literature, the incidence of retinopathy ranges from 30% to 67%.1,2 Cagianut3 reported 13 of 20 patients were severely incapacitated because of visual impairment. The ocular findings were first emphasized by Waldenström4 in his original report in 1944. Of 3 cases, the initial complaint in one patient was loss of vision due to a central vein occlusion, and the second had prominent dilated References 1. Logothetis, J.; Silverstein, P., and Coe, J.: Neurologic Aspects of Waldenström's Macroglobulinemia , Arch. Neurol. 3:564, 1960.Crossref 2. Schur, P. H., and Appel, L.: Waldenström's Macroglobulinemia with Pleural Effusion , New York J. Med. 61:2431, 1961. 3. Cagianut, B.: Ocular Syndrome of Macroglobulinemia , Ann. Oculist. (Par.) 191:579, 1958. 4. Waldenström, J.: Incipient Myelomatosis with "Essential" Hyperglobulinemia and Fibrinogenopenia: A New Syndrome? Acta Med. Scand. 117:216, 1944.Crossref 5. Waldenström, J.: Abnormal Proteins in Myeloma , Advance. Intern. Med. 5:398, 1952. 6. Willi, H.; Koller, F., and Raaflaub, J.: Symptomatische makroglobulinämie bei Lues congenita: Beitrag zur Frage der Fibrinasthenie Fanconi , Acta Haemat. (Basel) 11:316, 1954.Crossref 7. Wuhrmann, F.: Einige aktuelle klinische Probleme über die Serum-Globuline , Schweiz. Med. Wschr. 82:937, 1952. 8. Habich, H.: Zur Antigenanalyse der Paraproteine bei Makroglobulinämien , Schweiz. Med. Wschr. 83:1957, 1953. 9. Habich, H., and Hässig, A.: Essai d'analyse antigénique des paraprotides dans la macroglobulinémie du Waldenström , Vox Sang. 3:98, 1953. 10. Kanzow, U.; Scholtan, W., and Mütang, A.: Serologische Differenzierung von Makroglobulinämien , Klin. Wschr. 33:1043, 1955.Crossref 11. Sia, R. H. P.: Simple Method for Estimating Quantitative Differences in Kala-Azar , Chin. Med. J. 38:35, 1924. 12. Martin, N. H.: Macroglobulinaemia , Quart. J. Med. 29:179, 1960. 13. Wuhrmann, F.: Makroglobulinämie mit Stimmbandkarzinom , Helv. Med. Acta 24:268, 1957. 14. Schaub, F.: Gleichzeitiges Vorkommen von Makroglobulinämie Waldenström und von malignen Tumoren , Schweiz. Med. Wschr. 83:1256, 1953. 15. Waldenström, J.: Macroglobulinemia , Acta Haemat. (Basel) 20:33, 1958.Crossref 16. Laurell, C. B.; Laurell, H., and Waldenström, J.: Glycoproteins in Serum from Patients with Myeloma, Macroglobulinemia and Related Conditions , Amer. J. Med. 22:24, 1957.Crossref 17. Spalter, H. F.: Abnormal Serum Proteins and Retinal Vein Thrombosis , A.M.A. Arch. Ophthal. 62:868, 1959.Crossref 18. Cagianut, B., and Theiler, K.: Histology of Ocular Changes in Macroglobulinemia , Graefe. Arch. Ophth. 160:628, 1959.Crossref 19. Dutcher, T. F., and Fahey, J. L.: The Histopathology of the Macroglobulinemia of Waldenström , J. Nat. Cancer Inst. 22:887, 1959. 20. Pitney, W. R.; O'Sullivan, W. J., and Owen, J. A.: Effect of Prednisolone on Anemia Associated with Macroglobulinemia , Brit. Med. J. 2:1508, 1958.Crossref 21. Mackay, I. R.; Eriksen, N.; Motulsky, A. G., and Volwiler, W.: Cryo- and Macroglobulinemia , Amer. J. Med. 20:564, 1956.Crossref 22. Lawson, H. A.; Stuart, C. A.; Paull, A. M.; Phillips, A. M., and Phillips, R. W.: Observations on the Antibody Content of the Blood in Patients with Multiple Myeloma , New Engl. J. Med. 252:13, 1955.Crossref 23. Pachter, M. R.; Johnson, S. A.; Neblett, T. R., and Truant, J. P.: Bleeding, Platelets, and Macroglobulinemia , Amer. J. Clin. Path. 31: 467, 1959. 24. Macroglobulinemia, Clinicopathological Conference , Amer. J. Med. 28:951, 1960.Crossref 25. Deutsch, H. F., and Morton, J. I.: Dissociation of Human Serum Macroglobulins , Science 125:600, 1957.Crossref 26. Abraham, E. P.; Chain, E.; Baker, W., and Robinson, R.: Penicillamine, a Characteristic Degradation Product of Penicillin , Nature (Lond.) 151:107, 1943.Crossref 27. Walshe, J. M.: Penicillamine: A New Oral Therapy for Wilson's Disease , Amer. J. Med. 21:487, 1956.Crossref 28. Bloch, H. S.; Prasad, A., and Anastasi, A.: Serum Protein Changes in Waldenström's Macroglobulinemia During Penicillamine Administration , J. Lab. Clin. Med. 52:793, 1958. 29. Ritzmann, S. E.; Coleman, S. L., and Levin, W. C.: The Effect of Some Mercaptanes upon a Macrocryogelglobulin: Modifications Induced by Cysteamine, Penicillamine and Penicillin , J. Clin. Invest. 39:1320, 1960.Crossref 30. Levine, M. A.; Hammack, W. J., and Frommeyer, W. B.: Treatment of Macroglobulinemia with Penicillamine , Clin. Res. 8:54, 1960. 31. Strong, J. B., Jr.; Dempsey, H., and Hill, S. R., Jr.: The Successful Management of Hepatolenticular Degeneration with Penicillamine , Ann. Intern. Med. 54:198, 1961.Crossref 32. Scheinberg, I. H., and Sternlieb, I.: Penicillamine as the Basis of Therapy in Wilson's Disease , in Metal-Binding in Medicine , edited by M. J. Seven and L. A. Johnson, Philadelphia, J. B. Lippincott Company, 1960, p. 275. 33. Wilson, J. E., and DuVigneaud, V.: Inhibition of the Growth of the Rat by L-Penicillamine and Its Prevention by Aminoethanol and Its Related Compounds , J. Biol. Chem. 184:63, 1950. 34. Kuchinskas, E. J.; Horvath, A., and DuVigneaud, V.: An Anti-Vitamin B6 Action of L-Penicillamine , Arch. Biochem. 68:69, 1957.Crossref 35. DuVigneaud, V.; Kuchinskas, E. J., and Horvath, A.: L-Penicillamine and Rat Liver Transaminase Activity , Arch. Biochem. 69:130, 1957.Crossref 36. Aposhian, H. V., in Metal Binding in Medicine , edited by M. J. Seven and L. A. Johnson, Philadelphia, J. B. Lippincott Company, 1960, p. 304. 37. Schwab, P. J.; Okun, E., and Fahey, J. L.: Reversal of Retinopathy in Waldenström's Macroglobulinemia by Plasmapheresis , Arch. Ophthal. 64:515, 1960.Crossref 38. Coyle, J. T.; Frank, P. E.; Leonard, A. L., and Weiner, A.: Macroglobulinemia and Its Effect upon the Eye , Arch. Ophthal. 65:75, 1961.Crossref 39. Skoog, W. A., and Adams, W. S.: Plasmapheresis in a Case of Waldenström's Macroglobulinemia , Clin. Res. 7:96, 1959.

Journal

Archives of Ophthalmology – American Medical Association

Published: Jun 1, 1962

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