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The Normal Chinchilla Round Window Membrane

The Normal Chinchilla Round Window Membrane Abstract • The chinchilla round window membrane consists of three layers: (1) an outer epithelial layer facing the middle ear cavity with tight junctions and numerous desmosomes, (2) a middle connective-tissue layer consisting of fibroblasts, fibrocytes, collagen, elastin, capillaries, and myelinated and unmyelinated nerves, and (3) an inner cellular layer with thin cytoplasmic processes containing numerous micropinocytotic vesicles and dark granules similar in form to α-type glycogen. Studies of the fine structure of the normal round window membrane in animals are prerequisites to understanding the role of the round window membrane in both normal function and in diseased states such as otitis media. (Arch Otolaryngol 1982;108:550-554) References 1. Steckler RH, Cody DT: Ionophoresis of NA22 and I131 into the inner ear . Arch Otolaryngol 1966; 83:213.Crossref 2. D'Angelo EP, Patterson WC, Morrow RC: Chloramphenicol—topical applications in the middle ear . Arch Otolaryngol 1967;84:682-684.Crossref 3. Malinari GA: Alterations of inner ear mechanisms resulting from application of sodium chloride to the round window membrane . Ann Otol Rhinol Laryngol 1972;81:315-322. 4. Brady D, Pearce J, Juhn SK: Permeability of the round window membrane to 22Na or RISA . Arch Otolaryngol 1976;214:183-184. 5. Smith BM, Myers MG: The penetration of gentamicin and neomycin into perilymph across the round window membrane . Otolaryngol Head Neck Surg 1979;87:888-891. 6. Goycoolea MV, Paparella MM, Goldberg B, et al: Permeability of the middle ear to staphylococcal pyrogenic exotoxin in otitis media . Int J Pediatr Otorhinolaryngol 1980;1:301-308.Crossref 7. Arslan MM: Modifications of the osmotic pressure of perilymph and endolymph . Acta Otolaryngol 1969;67:360-377.Crossref 8. Hoft J: Die Permeabilitaat und die Beernflussung der Permeabilitat der Membran des Ruden Fenestus durch Pontocain (Tetracain) . Arch Klen Exp Ohr, Nas-U Kehlk Heilk 1969; 193:128-137.Crossref 9. Goycoolea MV, Paparella MM, Goldberg B, et al: Permeability of the round window membrane in otitis media . Arch Otolaryngol 1980; 106:430-433.Crossref 10. Goldberg B, Goycoolea MV, Schlievert PM, et al: Passage of albumin from the middle ear to the inner ear in otitis media in the chinchilla . Am J Otolaryngol 1981;2:211-214. 11. Paparella MM, Brady DR, Hoel R: Sensorineural hearing loss in chronic otitis media and mastoiditis . Trans Am Acad Ophthalmol Otolaryngol 1970;74:108-115. 12. Paparella MM, Makota O, Hiraide F, et al: Pathology of sensorineural hearing loss in otitis media . Ann Otol Rhinol Laryngol 1972;81:632-647. 13. Bellucci RJ, Fisher EG, Rhoden J: Ultrastructure of the round window membrane . Laryngoscope 1972;82:1021-1026.Crossref 14. Kawabata I, Paparella MM: Fine structure of the round window membrane . Ann Otol Rhinol Laryngol 1971;80:13-26. 15. Franke K: Freeze-fracture aspects of the junctional complexes in the round window membrane . Arch Otorhinolaryngol 1977;271:331-337.Crossref 16. Claude P, Goodenough DA: Fracture faces of zonulae occludentes from 'tight' and 'leaky' epithelia . J Cell Biol 1973;53:390-400.Crossref 17. Martinez-Palamo A, Erly D: Structure of tight junctions in epithelia with different permeability . Proc Natl Acad Sci USA 1975;72:4487-4491.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1982.00790570016004
Publisher site
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Abstract

Abstract • The chinchilla round window membrane consists of three layers: (1) an outer epithelial layer facing the middle ear cavity with tight junctions and numerous desmosomes, (2) a middle connective-tissue layer consisting of fibroblasts, fibrocytes, collagen, elastin, capillaries, and myelinated and unmyelinated nerves, and (3) an inner cellular layer with thin cytoplasmic processes containing numerous micropinocytotic vesicles and dark granules similar in form to α-type glycogen. Studies of the fine structure of the normal round window membrane in animals are prerequisites to understanding the role of the round window membrane in both normal function and in diseased states such as otitis media. (Arch Otolaryngol 1982;108:550-554) References 1. Steckler RH, Cody DT: Ionophoresis of NA22 and I131 into the inner ear . Arch Otolaryngol 1966; 83:213.Crossref 2. D'Angelo EP, Patterson WC, Morrow RC: Chloramphenicol—topical applications in the middle ear . Arch Otolaryngol 1967;84:682-684.Crossref 3. Malinari GA: Alterations of inner ear mechanisms resulting from application of sodium chloride to the round window membrane . Ann Otol Rhinol Laryngol 1972;81:315-322. 4. Brady D, Pearce J, Juhn SK: Permeability of the round window membrane to 22Na or RISA . Arch Otolaryngol 1976;214:183-184. 5. Smith BM, Myers MG: The penetration of gentamicin and neomycin into perilymph across the round window membrane . Otolaryngol Head Neck Surg 1979;87:888-891. 6. Goycoolea MV, Paparella MM, Goldberg B, et al: Permeability of the middle ear to staphylococcal pyrogenic exotoxin in otitis media . Int J Pediatr Otorhinolaryngol 1980;1:301-308.Crossref 7. Arslan MM: Modifications of the osmotic pressure of perilymph and endolymph . Acta Otolaryngol 1969;67:360-377.Crossref 8. Hoft J: Die Permeabilitaat und die Beernflussung der Permeabilitat der Membran des Ruden Fenestus durch Pontocain (Tetracain) . Arch Klen Exp Ohr, Nas-U Kehlk Heilk 1969; 193:128-137.Crossref 9. Goycoolea MV, Paparella MM, Goldberg B, et al: Permeability of the round window membrane in otitis media . Arch Otolaryngol 1980; 106:430-433.Crossref 10. Goldberg B, Goycoolea MV, Schlievert PM, et al: Passage of albumin from the middle ear to the inner ear in otitis media in the chinchilla . Am J Otolaryngol 1981;2:211-214. 11. Paparella MM, Brady DR, Hoel R: Sensorineural hearing loss in chronic otitis media and mastoiditis . Trans Am Acad Ophthalmol Otolaryngol 1970;74:108-115. 12. Paparella MM, Makota O, Hiraide F, et al: Pathology of sensorineural hearing loss in otitis media . Ann Otol Rhinol Laryngol 1972;81:632-647. 13. Bellucci RJ, Fisher EG, Rhoden J: Ultrastructure of the round window membrane . Laryngoscope 1972;82:1021-1026.Crossref 14. Kawabata I, Paparella MM: Fine structure of the round window membrane . Ann Otol Rhinol Laryngol 1971;80:13-26. 15. Franke K: Freeze-fracture aspects of the junctional complexes in the round window membrane . Arch Otorhinolaryngol 1977;271:331-337.Crossref 16. Claude P, Goodenough DA: Fracture faces of zonulae occludentes from 'tight' and 'leaky' epithelia . J Cell Biol 1973;53:390-400.Crossref 17. Martinez-Palamo A, Erly D: Structure of tight junctions in epithelia with different permeability . Proc Natl Acad Sci USA 1975;72:4487-4491.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Sep 1, 1982

References

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