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THE NONSPECIFIC PROTEIN REACTION

THE NONSPECIFIC PROTEIN REACTION Abstract A recent series of articles1 in the Archives of Internal Medicine merits considerable comment and criticism. Ling attempts to "study comparatively the influence of various nonspecific protein agents on the reactive temperature, . . . on the mobilization of peripheral blood leukocytes, . . . antibodies and enzymes." With the crude mixtures—horse serum, milk, peptone, vaccines, yeast, crotalin—used by him it is obvious that the results obtained cannot be arbitrarily saddled on any one constituent, and also that any attempt to evaluate the results quantitatively is useless. Ling admits in his article that distilled water produces similar reactions to those produced by the protein mixtures. It was shown in a series of articles2 in the American Journal of Physiology that distilled water, even if it has been sterilized, is capable of producing considerable fever when injected intravenously, and this is because the water had at some time been contaminated by References 1. Ling, C. Y.: Mechanism of Reaction of Nonspecific Protein Agents in Treatment of Disease, I, Influence of Various Agents on Temperature and Leukocyte Counts in Normal Persons and in Rabbits , Arch. Int. Med. 35:598-608 ( (May) ) 1925Crossref 2. II, Influence of Various Agents in Mobilization of Blood Antibodies , Ling Arch. Int. Med. 35:740-751 ( (June) ) 1925.Crossref 3. Seibert, F. B., and Mendel, L. B.: Temperature Variations in Rabbits , Am. J. Physiol. 67:83-89 ( (Dec.) ) 1923. 4. Seibert, F. B.: Fever Producing Substance Found in Some Distilled Waters , Am. J. Physiol. 67:90-104 ( (Dec.) ) 1923 5. Protein Fevers , Seibert Am. J. Physiol. 67:105-23 ( (Dec.) ) 1923 6. Cause of Many Febrile Reactions Following Intravenous Injections , Seibert Am. J. Physiol. 71:621-651 ( (Feb.) ) 1925. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE NONSPECIFIC PROTEIN REACTION

Archives of Internal Medicine , Volume 36 (5) – Nov 1, 1925

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1925 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1925.00120170156012
Publisher site
See Article on Publisher Site

Abstract

Abstract A recent series of articles1 in the Archives of Internal Medicine merits considerable comment and criticism. Ling attempts to "study comparatively the influence of various nonspecific protein agents on the reactive temperature, . . . on the mobilization of peripheral blood leukocytes, . . . antibodies and enzymes." With the crude mixtures—horse serum, milk, peptone, vaccines, yeast, crotalin—used by him it is obvious that the results obtained cannot be arbitrarily saddled on any one constituent, and also that any attempt to evaluate the results quantitatively is useless. Ling admits in his article that distilled water produces similar reactions to those produced by the protein mixtures. It was shown in a series of articles2 in the American Journal of Physiology that distilled water, even if it has been sterilized, is capable of producing considerable fever when injected intravenously, and this is because the water had at some time been contaminated by References 1. Ling, C. Y.: Mechanism of Reaction of Nonspecific Protein Agents in Treatment of Disease, I, Influence of Various Agents on Temperature and Leukocyte Counts in Normal Persons and in Rabbits , Arch. Int. Med. 35:598-608 ( (May) ) 1925Crossref 2. II, Influence of Various Agents in Mobilization of Blood Antibodies , Ling Arch. Int. Med. 35:740-751 ( (June) ) 1925.Crossref 3. Seibert, F. B., and Mendel, L. B.: Temperature Variations in Rabbits , Am. J. Physiol. 67:83-89 ( (Dec.) ) 1923. 4. Seibert, F. B.: Fever Producing Substance Found in Some Distilled Waters , Am. J. Physiol. 67:90-104 ( (Dec.) ) 1923 5. Protein Fevers , Seibert Am. J. Physiol. 67:105-23 ( (Dec.) ) 1923 6. Cause of Many Febrile Reactions Following Intravenous Injections , Seibert Am. J. Physiol. 71:621-651 ( (Feb.) ) 1925.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1925

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