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The Neuropsychology of the Cerebellum: An Emerging Concept

The Neuropsychology of the Cerebellum: An Emerging Concept Abstract To the Editor. —I read with utmost interest Schmahmann's article1 on the cerebellar contribution to higher function. This article, however, seems to be incomplete. The association between cerebellar damage and mental or neuropsychologic disorders has sometimes been mentioned in the literature, but no firm clinical and physiopathologic (cause-effect) relationships were documented in neurologic patients before our article2 was published in 1985, in which we emphasized the role of cerebellofrontal and cerebelloparietal pathways as anatomic substrata of the mild frontal and parietal-like syndrome encountered in our patients. After publication of this article,2 our laboratory undertook to answer the following questions: (1) Which are the specific (if indeed they are) neuropsychologic disorders associated with well-delimited bilateral cerebellar damage (BCD) vs those found in patients with unilateral cerebellar damage (UCD)2; (2) Which are the anatomic, metabolic, or neurochemical substrata subserving these disorders?; (3) Will neurobehavioral studies on mutant mice References 1. Schmahmann JD. An emerging concept: the cerebellar contribution to higher function . Arch Neurol . 1990;48:1178-1187.Crossref 2. Botez MI, Gravel J, Attig E, Vézina JL. Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought . Neurology . 1985;35:1152-1157.Crossref 3. Botez T, Botez MI, Cardu B, Léveillé J. Speed of information processing and its relationship to intelligence at various levels of the central nervous system . Neurology . 1989;39( (suppl 1) ): 318. Abstract.Crossref 4. Botez MI, Botez T, Elie R, Attig E. Role of the cerebellum in complex human behavior . Ital J Neurol Sci . 1989;10:291-300.Crossref 5. Botez MI, Léveillé J, Botez T. Role of the cerebellum in cognitive thought: SPECT and neuropsychological findings . In: Matheson M, Newman H, eds. Rehabilitation: The Path Back . Richmond, Australia: Australian Society for the Study of Brain Impairment. 1989:179-195. 6. Botez Ml, Botez T, Léveillé J, Lambert R. Cerebello-cerebral diaschisis and the role of the cerebellum in cognition . Neurology 1990;40 ( (suppl 1) ):173. Abstract. 7. El-Awar M, Kish S, Oscar-Berman M, Robitaille Y, Schut L, Freedman M. Selective delayed alternation deficits in dominantly inherited olivopontocerebellar atrophy . Brain Cogn 1991;16:121-129.Crossref 8. Botez T, Botez Ml. Unilateral and bilateral cerebellar lesions: neuropsychological performances . Neurology . 1992;42( (suppl 3) ):290. Abstract. 9. Amrani K, Pellerin JP, Lamarre Y. The effect of bilateral lesions of the cerebellar nuclei on motor performance in the monkey . Soc Neurosci Abstr . 1988;14:1239. 10. Wallesch CW, Horn A. Long-term effects of cerebellar pathology on cognitive functions . Brain Cogn . 1990;14:19-25.Crossref 11. Bracke-Tolkmitt R, Linden A, Canavan AGM, et al. C. The cerebellum contributes to mental skills . Behav Neurosci . 1989;103:442-446.Crossref 12. Inhoff AW, Diener HC, Rafal RD, Ivry R. The role of cerebellar structures in the execution of serial movements . Brain . 1989;112:565-581.Crossref 13. Botez MI, Léveillé J, Lambert R, Botez T. Single photon emission computerized tomotraphy (SPECT) in cerebellar disease: cerebellocerebral diaschisis . Eur Neurol . 1991;31:405-412.Crossref 14. Snider RA, Maiti A, Snider SR. Cerebellar pathways to ventral midbrain and nigra . Exp Neurol . 1976;53:714-728.Crossref 15. Amalric M, Koob GF. Depletion of dopamine in the caudate nucleus impairs reaction-time performance in rats . J Neurosci . 1987;7:2129-2134. 16. Botez MI, Young SN, Botez T, Pedraza OL. Treatment of heredodegenerative ataxias with amantadine hydrochloride . Can J Neurol Sci . 1991;18:307-311. 17. Panagapoulos NT, Papadopoulos GC, Matsokis NA. Dopaminergic innervation and binding in the rat cerebellum . Neurosci Letters . 1991;130:208-212.Crossref 18. Lalonde R, Botez Ml. The cerebellum and learning processing in animals . Brain Res Rev . 1990;15:325-332.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

The Neuropsychology of the Cerebellum: An Emerging Concept

Archives of Neurology , Volume 49 (12) – Dec 1, 1992

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Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1992.00530360027009
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —I read with utmost interest Schmahmann's article1 on the cerebellar contribution to higher function. This article, however, seems to be incomplete. The association between cerebellar damage and mental or neuropsychologic disorders has sometimes been mentioned in the literature, but no firm clinical and physiopathologic (cause-effect) relationships were documented in neurologic patients before our article2 was published in 1985, in which we emphasized the role of cerebellofrontal and cerebelloparietal pathways as anatomic substrata of the mild frontal and parietal-like syndrome encountered in our patients. After publication of this article,2 our laboratory undertook to answer the following questions: (1) Which are the specific (if indeed they are) neuropsychologic disorders associated with well-delimited bilateral cerebellar damage (BCD) vs those found in patients with unilateral cerebellar damage (UCD)2; (2) Which are the anatomic, metabolic, or neurochemical substrata subserving these disorders?; (3) Will neurobehavioral studies on mutant mice References 1. Schmahmann JD. An emerging concept: the cerebellar contribution to higher function . Arch Neurol . 1990;48:1178-1187.Crossref 2. Botez MI, Gravel J, Attig E, Vézina JL. Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought . Neurology . 1985;35:1152-1157.Crossref 3. Botez T, Botez MI, Cardu B, Léveillé J. Speed of information processing and its relationship to intelligence at various levels of the central nervous system . Neurology . 1989;39( (suppl 1) ): 318. Abstract.Crossref 4. Botez MI, Botez T, Elie R, Attig E. Role of the cerebellum in complex human behavior . Ital J Neurol Sci . 1989;10:291-300.Crossref 5. Botez MI, Léveillé J, Botez T. Role of the cerebellum in cognitive thought: SPECT and neuropsychological findings . In: Matheson M, Newman H, eds. Rehabilitation: The Path Back . Richmond, Australia: Australian Society for the Study of Brain Impairment. 1989:179-195. 6. Botez Ml, Botez T, Léveillé J, Lambert R. Cerebello-cerebral diaschisis and the role of the cerebellum in cognition . Neurology 1990;40 ( (suppl 1) ):173. Abstract. 7. El-Awar M, Kish S, Oscar-Berman M, Robitaille Y, Schut L, Freedman M. Selective delayed alternation deficits in dominantly inherited olivopontocerebellar atrophy . Brain Cogn 1991;16:121-129.Crossref 8. Botez T, Botez Ml. Unilateral and bilateral cerebellar lesions: neuropsychological performances . Neurology . 1992;42( (suppl 3) ):290. Abstract. 9. Amrani K, Pellerin JP, Lamarre Y. The effect of bilateral lesions of the cerebellar nuclei on motor performance in the monkey . Soc Neurosci Abstr . 1988;14:1239. 10. Wallesch CW, Horn A. Long-term effects of cerebellar pathology on cognitive functions . Brain Cogn . 1990;14:19-25.Crossref 11. Bracke-Tolkmitt R, Linden A, Canavan AGM, et al. C. The cerebellum contributes to mental skills . Behav Neurosci . 1989;103:442-446.Crossref 12. Inhoff AW, Diener HC, Rafal RD, Ivry R. The role of cerebellar structures in the execution of serial movements . Brain . 1989;112:565-581.Crossref 13. Botez MI, Léveillé J, Lambert R, Botez T. Single photon emission computerized tomotraphy (SPECT) in cerebellar disease: cerebellocerebral diaschisis . Eur Neurol . 1991;31:405-412.Crossref 14. Snider RA, Maiti A, Snider SR. Cerebellar pathways to ventral midbrain and nigra . Exp Neurol . 1976;53:714-728.Crossref 15. Amalric M, Koob GF. Depletion of dopamine in the caudate nucleus impairs reaction-time performance in rats . J Neurosci . 1987;7:2129-2134. 16. Botez MI, Young SN, Botez T, Pedraza OL. Treatment of heredodegenerative ataxias with amantadine hydrochloride . Can J Neurol Sci . 1991;18:307-311. 17. Panagapoulos NT, Papadopoulos GC, Matsokis NA. Dopaminergic innervation and binding in the rat cerebellum . Neurosci Letters . 1991;130:208-212.Crossref 18. Lalonde R, Botez Ml. The cerebellum and learning processing in animals . Brain Res Rev . 1990;15:325-332.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Dec 1, 1992

References