Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

THE MORE RECENT DEVELOPMENTS IN THE STUDY OF ANAPHYLACTIC PHENOMENA

THE MORE RECENT DEVELOPMENTS IN THE STUDY OF ANAPHYLACTIC PHENOMENA Abstract It is a fundamental biological truth that the systematic treatment of an animal with a foreign protein, if this is administered by any route other than that of the alimentary canal, induces profound physiological changes. These changes are primarily recognizable by the appearance in the circulating blood of substances which superficially react with the injected protein. For convenience of discussion we speak of these reaction products as antibodies, and of the injected substances, which possess this power of inducing their formation, as antigens. Antigens, then, are all substances which injected into the animal body, induce specific antibody formation. They form a large group in nature and are chemically proteins ; indeed, we may say that all known proteins may act as antigens. Whether or not this term may also include lipoid-protein combinations, lipoids or the higher protein derivatives is as yet uncertain and need not in the present connection concern References 1. Morgenroth: Ehrlich Gesammelte Arbeiten , translation, Wiley & Son, New York, 1906, footnote, p. 332. 2. Richet and Héricourt : Compt. rend. Soc. de biol. , 1898, xv, 137. 3. Arthus : Compt. rend. Soc. de biol. , lv, 817. 4. Von Pirquet and Schick: Die Serumkrankheit , Wien, Deuticke, 1906. 5. Rosenau and Anderson: Bull. 29, U. S. P. H. S., 1906 6. Bull. 30, 1906 7. Bull. 36, 1907 8. Jour. Med. Research , 1906, xv 9. Jour. Med. Research ., 1907, xvi 10. Jour. Infect. Dis. , 1907, iv 11. Jour. Infect. Dis. ., 1908, v. 12. Otto: Das Theobald Smithsche Phaenomen, etc., von Leuthold Gedenkschrift, 1905, i. 13. Gay and Southard: Jour. Med. Research , 1907, xvi. 14. Besredka: Bull. de l'Inst. Pasteur , 1908, vi, 826. 15. The curious changes in the coagulation of the blood during the anaphylaxis have led to an interesting and important theoretical conception, namely, that the meeting of antigen and antibody may not, as otherwise believed, lead directly to the formation of a poison, but that in some way the results of such a union may influence the coagulation processes and that these alterations are the direct cause of shock. The first to give serious attention to such a train of reasoning was probably Nolf, and Doerr has recently called attention to the work of a number of investigators (recently confirmed by Moldevan) who observed that freshly defibrinated blood, i. e., blood in which the normal coagulation has been interrupted, may be toxic even when reinjected into the same animal. The same is true of serum taken from rapidly defibrinated blood. There is at least a possibility, then, that the anaphylactic injury is the result of an alteration in the blood indirectly brought about by the union of antigen and antibody. However, the premises for such reasoning are still very vague, and moreover, any view which introduces the various elements which participate in blood coagulating processes can have no part in such manifestations as those observed on isolated and washed tissues, as in the experiments of Schultz and Dale. 16. Vaughan: Protein Split Products, etc. , Lea & Febiger, 1913. 17. Friedemann: Ztschr. f. Immunitätsforsch. u. exper. Therap. , 1909, ii. 18. Friedberger: Berl. klin. Wchnschr. , 1910, Nos. (32) and 42 19. Ztschr. f. Immunitätsforsch. , 1910, iv. 20. Keysser and Wassermann: Folia serol. , 1911, vii 21. Ztschr. f. Hyg. u. Infectionskrankh. , 1911, lxviii. 22. Bordet: Compt. rend. Soc. de biol. , 1913, lxxiv, 877. 23. Jobling and Peterson : Jour. Exper. Med. , 1914, xix, No. (5) . 24. Zinsser and Dwyer : Jour. Exper. Med. , 1914, xx, No. (6) . 25. Zinsser: Jour. Exper. Med. , 1912, xv, No. (5) 26. 1913, xviii, 219. 27. Sleeswijk : Ztschr. f. Immunitätsforsch. , 1909, ii. 28. Friedberger and Hartoch: Ztschr. f. Immunitätsforsch. , 1909, iii. 29. Loeffler : Ztschr. f. Immunitätsforsch. , 1910, viii. 30. Hartoch and Sirenskij : Ztschr. f. Immunitätsforsch. , 1910, vii. 31. Nolf: Ann. de l'Inst. Pasteur , 1900, xiv. 32. Hektoen and Ruediger : Jour. Infect. Dis. , 1904, i. 33. Friedberger and Hartoch : Ztschr. f. Immunitätsforsch. , 1909, iii. 34. Ritz, cited by Doerr : Footnote 29. 35. Zinsser and Dwyer : To be published. 36. Doerr and Russ : Ztschr. f. Immunitätsforsch. , 1909, iii. 37. Friedberger : Ztschr. f. Immunitätsforsch. , 1909, ii. 38. Doerr : Ergebnisse der Immunitätsforschung , edited by Weichhardt, Berlin, 1914, i, 257. 39. Pearce and Eisenbrey : Congr. Am. Phys. and Surg. , 1910, viii. 40. Schultz : Jour. Pharmacol. and Exper. Therap. , 1910, i. 41. Dale : Jour. Pharmacol. and Exper. Therap. , 1913, iv. 42. Weil, R.: Jour. Med. Research , 27, 1913 43. 30, 1914 44. Proc. Soc. Exper. Biol. and Med. , 1914, xi, 86. 45. Coca : Ztschr. f. Immunitätsforsch. , 1914, xx. 46. Biedl and Kraus: Ztschr. f. Immunitätsforsch. , 1910, iv. 47. Briot: Compt. rend. Soc. de biol. , 1910, lxviii, 402. 48. Gurd: Jour. Med. Research , 1914, xxxi, 205. 49. Linossier and Lemoine: Compt. rend. Soc. de biol. , 1902, liv, 85. 50. Eisenberg, P.: Centralbl. f. Bakteriol. , 1903, Orig., xxxiv, Part (1) , p. 259. 51. Ascoli, M.: München. med. Wchnschr. , 1902, xlix, 1409. 52. V. Dungern: Centralbl. f. Bakteriol. , 1903, Orig., xxxiv, Part (1) , p. 355. 53. Von Dungern : Centralbl. f. Bacteriol. , 1903, xxxiv, first part orig. 54. Zinsser and Young: On the Possible Importance of Colloidal Protection in Certain Phases of the Precipitin Reaction , Jour. Exper. Med. , 1913, xvii, 396.Crossref 55. Porges, O.: In Kraus and Levaditi: Handb. d. Technik u. Methodik der Imm., Jena , 1909, ii, 1146. 56. Friedemann: Ztschr. f. Hyg. , 1910, lxvii. 57. Schmidt: Ztschr. f. Hyg. , 1911, lxix. 58. Landsteiner and Pauli: Cited from Landsteiner, " Colloide u. Lippoide in der Immunität ," from Kolle and Wassermann, Ed. 2, ii, 1244. 59. Doerr and Moldovan: Ztschr. f. Immunitätsforsch. , 1910, vii. 60. Zinsser: Jour. Exper. Med. , 1911, xiv, No. (1) . 61. Schiff and Moore : Ztschr. f. Immunitätsforsch. , 1914, xxii. 62. Amako: Ztschr. f. Immunitätsforsch. , 1914, xxii. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE MORE RECENT DEVELOPMENTS IN THE STUDY OF ANAPHYLACTIC PHENOMENA

Archives of Internal Medicine , Volume XVI (2) – Aug 1, 1915

Loading next page...
 
/lp/american-medical-association/the-more-recent-developments-in-the-study-of-anaphylactic-phenomena-0vo9FsU45Q
Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00080020077006
Publisher site
See Article on Publisher Site

Abstract

Abstract It is a fundamental biological truth that the systematic treatment of an animal with a foreign protein, if this is administered by any route other than that of the alimentary canal, induces profound physiological changes. These changes are primarily recognizable by the appearance in the circulating blood of substances which superficially react with the injected protein. For convenience of discussion we speak of these reaction products as antibodies, and of the injected substances, which possess this power of inducing their formation, as antigens. Antigens, then, are all substances which injected into the animal body, induce specific antibody formation. They form a large group in nature and are chemically proteins ; indeed, we may say that all known proteins may act as antigens. Whether or not this term may also include lipoid-protein combinations, lipoids or the higher protein derivatives is as yet uncertain and need not in the present connection concern References 1. Morgenroth: Ehrlich Gesammelte Arbeiten , translation, Wiley & Son, New York, 1906, footnote, p. 332. 2. Richet and Héricourt : Compt. rend. Soc. de biol. , 1898, xv, 137. 3. Arthus : Compt. rend. Soc. de biol. , lv, 817. 4. Von Pirquet and Schick: Die Serumkrankheit , Wien, Deuticke, 1906. 5. Rosenau and Anderson: Bull. 29, U. S. P. H. S., 1906 6. Bull. 30, 1906 7. Bull. 36, 1907 8. Jour. Med. Research , 1906, xv 9. Jour. Med. Research ., 1907, xvi 10. Jour. Infect. Dis. , 1907, iv 11. Jour. Infect. Dis. ., 1908, v. 12. Otto: Das Theobald Smithsche Phaenomen, etc., von Leuthold Gedenkschrift, 1905, i. 13. Gay and Southard: Jour. Med. Research , 1907, xvi. 14. Besredka: Bull. de l'Inst. Pasteur , 1908, vi, 826. 15. The curious changes in the coagulation of the blood during the anaphylaxis have led to an interesting and important theoretical conception, namely, that the meeting of antigen and antibody may not, as otherwise believed, lead directly to the formation of a poison, but that in some way the results of such a union may influence the coagulation processes and that these alterations are the direct cause of shock. The first to give serious attention to such a train of reasoning was probably Nolf, and Doerr has recently called attention to the work of a number of investigators (recently confirmed by Moldevan) who observed that freshly defibrinated blood, i. e., blood in which the normal coagulation has been interrupted, may be toxic even when reinjected into the same animal. The same is true of serum taken from rapidly defibrinated blood. There is at least a possibility, then, that the anaphylactic injury is the result of an alteration in the blood indirectly brought about by the union of antigen and antibody. However, the premises for such reasoning are still very vague, and moreover, any view which introduces the various elements which participate in blood coagulating processes can have no part in such manifestations as those observed on isolated and washed tissues, as in the experiments of Schultz and Dale. 16. Vaughan: Protein Split Products, etc. , Lea & Febiger, 1913. 17. Friedemann: Ztschr. f. Immunitätsforsch. u. exper. Therap. , 1909, ii. 18. Friedberger: Berl. klin. Wchnschr. , 1910, Nos. (32) and 42 19. Ztschr. f. Immunitätsforsch. , 1910, iv. 20. Keysser and Wassermann: Folia serol. , 1911, vii 21. Ztschr. f. Hyg. u. Infectionskrankh. , 1911, lxviii. 22. Bordet: Compt. rend. Soc. de biol. , 1913, lxxiv, 877. 23. Jobling and Peterson : Jour. Exper. Med. , 1914, xix, No. (5) . 24. Zinsser and Dwyer : Jour. Exper. Med. , 1914, xx, No. (6) . 25. Zinsser: Jour. Exper. Med. , 1912, xv, No. (5) 26. 1913, xviii, 219. 27. Sleeswijk : Ztschr. f. Immunitätsforsch. , 1909, ii. 28. Friedberger and Hartoch: Ztschr. f. Immunitätsforsch. , 1909, iii. 29. Loeffler : Ztschr. f. Immunitätsforsch. , 1910, viii. 30. Hartoch and Sirenskij : Ztschr. f. Immunitätsforsch. , 1910, vii. 31. Nolf: Ann. de l'Inst. Pasteur , 1900, xiv. 32. Hektoen and Ruediger : Jour. Infect. Dis. , 1904, i. 33. Friedberger and Hartoch : Ztschr. f. Immunitätsforsch. , 1909, iii. 34. Ritz, cited by Doerr : Footnote 29. 35. Zinsser and Dwyer : To be published. 36. Doerr and Russ : Ztschr. f. Immunitätsforsch. , 1909, iii. 37. Friedberger : Ztschr. f. Immunitätsforsch. , 1909, ii. 38. Doerr : Ergebnisse der Immunitätsforschung , edited by Weichhardt, Berlin, 1914, i, 257. 39. Pearce and Eisenbrey : Congr. Am. Phys. and Surg. , 1910, viii. 40. Schultz : Jour. Pharmacol. and Exper. Therap. , 1910, i. 41. Dale : Jour. Pharmacol. and Exper. Therap. , 1913, iv. 42. Weil, R.: Jour. Med. Research , 27, 1913 43. 30, 1914 44. Proc. Soc. Exper. Biol. and Med. , 1914, xi, 86. 45. Coca : Ztschr. f. Immunitätsforsch. , 1914, xx. 46. Biedl and Kraus: Ztschr. f. Immunitätsforsch. , 1910, iv. 47. Briot: Compt. rend. Soc. de biol. , 1910, lxviii, 402. 48. Gurd: Jour. Med. Research , 1914, xxxi, 205. 49. Linossier and Lemoine: Compt. rend. Soc. de biol. , 1902, liv, 85. 50. Eisenberg, P.: Centralbl. f. Bakteriol. , 1903, Orig., xxxiv, Part (1) , p. 259. 51. Ascoli, M.: München. med. Wchnschr. , 1902, xlix, 1409. 52. V. Dungern: Centralbl. f. Bakteriol. , 1903, Orig., xxxiv, Part (1) , p. 355. 53. Von Dungern : Centralbl. f. Bacteriol. , 1903, xxxiv, first part orig. 54. Zinsser and Young: On the Possible Importance of Colloidal Protection in Certain Phases of the Precipitin Reaction , Jour. Exper. Med. , 1913, xvii, 396.Crossref 55. Porges, O.: In Kraus and Levaditi: Handb. d. Technik u. Methodik der Imm., Jena , 1909, ii, 1146. 56. Friedemann: Ztschr. f. Hyg. , 1910, lxvii. 57. Schmidt: Ztschr. f. Hyg. , 1911, lxix. 58. Landsteiner and Pauli: Cited from Landsteiner, " Colloide u. Lippoide in der Immunität ," from Kolle and Wassermann, Ed. 2, ii, 1244. 59. Doerr and Moldovan: Ztschr. f. Immunitätsforsch. , 1910, vii. 60. Zinsser: Jour. Exper. Med. , 1911, xiv, No. (1) . 61. Schiff and Moore : Ztschr. f. Immunitätsforsch. , 1914, xxii. 62. Amako: Ztschr. f. Immunitätsforsch. , 1914, xxii.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1915

References