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J. Collip (1925)
The Internal Secretion of the Parathyroid Glands.Proceedings of the National Academy of Sciences of the United States of America, 11 8
The subject of delayed union and nonunion of fractures is still in a state of confusion. The orthopedic surgeon has made great strides in his department of the practice of medicine, but this progress is limited largely to the mechanical aspects of orthopedics. He has not scientifically explained the causes of delayed union or nonunion of fractures or of bone disease, especially arthritis. The literature on factors concerned in metabolism of bone is confusing and is to a great extent confined to the study of individual elements without due regard to the relationship of all the physicochemical processes involved and their clinical interpretation and application to growth and regeneration of bone. Some suggestions as to the medical management of fractures, based on a large number of clinical cases as well as on considerable experimental evidence, should be of interest at this time. The suggestions offered here are based first on
JAMA – American Medical Association
Published: Jan 18, 1941
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