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The Management of Unilateral Retinoblastoma Without Primary Enucleation

The Management of Unilateral Retinoblastoma Without Primary Enucleation Abstract • Sixty-six patients were treated "conservatively" for unilateral retinoblastoma. Forty-eight of 57 (84%) were treated primarily with unilateral radiation, one patient was treated with a cobalt plaque, and eight patients were treated with either cryopexy or xenon arc photocoagulation. With a median follow-up of 73 months, there have been no deaths. Five of 39 eyes that were in groups I to III have been salvaged. Virtually all eyes in groups IV and V (12 of 14) came to enucleation. The age at diagnosis for patients with a positive family history was early (2.5 months), and the patients had a greater number of individual tumors in one eye (2.4), compared with those without a positive family history (27 months, 1.2 tumors per eye). When unilateral retinoblastoma is detected at an early age, the most common sign is strabismus, not leukokoria. References 1. Ellsworth RM: Retinoblastoma . Mod Probl Ophthalmol 1977;18:94-100. 2. Jensen RD, Miller RW: Retinoblastoma: Epidemiologic characteristics . N Engl J Med 1971; 285:307-311.Crossref 3. Lennox EL, Draper GJ, Sanders BM: Retinoblastoma: A study of natural history and prognosis: 268 cases . Br Med J 1975;3:731-734.Crossref 4. François J: Conservative treatment of retinoblastoma . Mod Probl Ophthalmol 1977;18:113-118. 5. Hopping W: Ziele und Erbegnisse unserer Retinoblastomateilung, 1959-1968 . Ber Zusammenkunft Dtsch Ophthalmol Ges 1969;69:912-914. 6. Schipper J: Retinoblastoma: A Medical and Experimental Study, thesis. Utrecht, the Netherlands, 1980. 7. Stallard HB: Radiotherapy of malignant intraocular neoplasms . Br J Ophthalmol 1948; 32:618-639.Crossref 8. Abramson DH, Adams K, Ellsworth RM, et al: Simultaneous bilateral radiation for advanced bilateral retinoblastoma . Arch Ophthalmol 1981; 99:1763-1766.Crossref 9. Abramson DH, Javitt J, Ellsworth RM, et al: Treatment of bilateral groups I through III retinoblastoma with bilateral radiation . Arch Ophthalmol 1981;99:1761-1762.Crossref 10. Hopping W, Schmitt G: The treatment of retinoblastoma . Mod Probl Ophthalmol 1977; 18:106-113. 11. Egbert PR, Donaldson SS, Moazed K, et al: Visual results and ocular complications following radiotherapy for retinoblastoma . Arch Ophthalmol 1978;96:1826-1830.Crossref 12. Carlson EA, Letson MD, Ramsay NKC, et al: Factors for improved genetic counselling for retinoblastoma based on a survey of 55 families . Am J Ophthalmol 1979;87:449-459. 13. Ellsworth RM: The practical management of retinoblastoma . Trans Am Ophthalmol Soc 1969;67:462-534. 14. Abramson DH, Ellsworth RM, Zimmerman LE: Nonocular cancer in retinoblastoma survivors . Trans Am Acad Ophthalmol Otolaryngol 1975;81:454-457. 15. Abramson DH, Ronner HJ, Ellsworth RM: Second tumors in nonirradiated bilateral retinoblastoma . Am J Ophthalmol 1979;87:624-627. 16. Kitchin FD: Genetic of retinoblastoma , in Reese AB (ed): Tumors of the Eye , ed 3. Hagerstown, Md, Harper & Row Publishers Inc, 1976, pp 125-132. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Management of Unilateral Retinoblastoma Without Primary Enucleation

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040227002
Publisher site
See Article on Publisher Site

Abstract

Abstract • Sixty-six patients were treated "conservatively" for unilateral retinoblastoma. Forty-eight of 57 (84%) were treated primarily with unilateral radiation, one patient was treated with a cobalt plaque, and eight patients were treated with either cryopexy or xenon arc photocoagulation. With a median follow-up of 73 months, there have been no deaths. Five of 39 eyes that were in groups I to III have been salvaged. Virtually all eyes in groups IV and V (12 of 14) came to enucleation. The age at diagnosis for patients with a positive family history was early (2.5 months), and the patients had a greater number of individual tumors in one eye (2.4), compared with those without a positive family history (27 months, 1.2 tumors per eye). When unilateral retinoblastoma is detected at an early age, the most common sign is strabismus, not leukokoria. References 1. Ellsworth RM: Retinoblastoma . Mod Probl Ophthalmol 1977;18:94-100. 2. Jensen RD, Miller RW: Retinoblastoma: Epidemiologic characteristics . N Engl J Med 1971; 285:307-311.Crossref 3. Lennox EL, Draper GJ, Sanders BM: Retinoblastoma: A study of natural history and prognosis: 268 cases . Br Med J 1975;3:731-734.Crossref 4. François J: Conservative treatment of retinoblastoma . Mod Probl Ophthalmol 1977;18:113-118. 5. Hopping W: Ziele und Erbegnisse unserer Retinoblastomateilung, 1959-1968 . Ber Zusammenkunft Dtsch Ophthalmol Ges 1969;69:912-914. 6. Schipper J: Retinoblastoma: A Medical and Experimental Study, thesis. Utrecht, the Netherlands, 1980. 7. Stallard HB: Radiotherapy of malignant intraocular neoplasms . Br J Ophthalmol 1948; 32:618-639.Crossref 8. Abramson DH, Adams K, Ellsworth RM, et al: Simultaneous bilateral radiation for advanced bilateral retinoblastoma . Arch Ophthalmol 1981; 99:1763-1766.Crossref 9. Abramson DH, Javitt J, Ellsworth RM, et al: Treatment of bilateral groups I through III retinoblastoma with bilateral radiation . Arch Ophthalmol 1981;99:1761-1762.Crossref 10. Hopping W, Schmitt G: The treatment of retinoblastoma . Mod Probl Ophthalmol 1977; 18:106-113. 11. Egbert PR, Donaldson SS, Moazed K, et al: Visual results and ocular complications following radiotherapy for retinoblastoma . Arch Ophthalmol 1978;96:1826-1830.Crossref 12. Carlson EA, Letson MD, Ramsay NKC, et al: Factors for improved genetic counselling for retinoblastoma based on a survey of 55 families . Am J Ophthalmol 1979;87:449-459. 13. Ellsworth RM: The practical management of retinoblastoma . Trans Am Ophthalmol Soc 1969;67:462-534. 14. Abramson DH, Ellsworth RM, Zimmerman LE: Nonocular cancer in retinoblastoma survivors . Trans Am Acad Ophthalmol Otolaryngol 1975;81:454-457. 15. Abramson DH, Ronner HJ, Ellsworth RM: Second tumors in nonirradiated bilateral retinoblastoma . Am J Ophthalmol 1979;87:624-627. 16. Kitchin FD: Genetic of retinoblastoma , in Reese AB (ed): Tumors of the Eye , ed 3. Hagerstown, Md, Harper & Row Publishers Inc, 1976, pp 125-132.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Aug 1, 1982

References