Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

The MAGIC Syndrome (Mouth and Genital Ulcers With Inflamed Cartilage)

The MAGIC Syndrome (Mouth and Genital Ulcers With Inflamed Cartilage) Abstract • We describe a 42-year-old man with features of both Behçet's disease and relapsing polychondritis. The term MAGIC syndrome (mouth and genital ulcers with inflamed cartilage) has previously been used to describe similarly affected patients. We discuss the diagnostic criteria and pathogenetic mechanisms. (Arch Dermatol. 1990;126:940-944) References 1. Firestein GS, Gruber HE, Weisman MH, Zvaifler NJ. Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome . Am J Med. 1985;79:65-72.Crossref 2. Esdaile J, Hawkins D, Gold P, Freedman SO, Duguid WP. Vascular involvement in relapsing polychondritis . Can Med Assoc J. 1977;116:1019-1022. 3. McKay DAR, Watson PG, Lyne AJ. Relapsing polychondritis and eye disease . Br J Ophthalmol. 1974;58:600-605.Crossref 4. Menkes J, Siaud JR, Delbrieu F, Chouraki L, Bellaiche D, Delbarre F. Polychondrite chronique atrophiante: deux case, dont l'un avec cataracte et arterite des membres inferieurs . Ann Med Interne (Paris). 1970;121:895-904. 5. Saurat JH, Noury-Duperrat G, Delanoe J, Kernbaum S, Frottier J, Puisant A. Les manifestations cutanees de la polychondrite chronique atrophiante et leurs rapports avec l'aphtose . Ann Dermatol Venereol. 1972;102:145-156. 6. Prentice RL, Gatenby PA, Dagleish AG, Baston AB. Relapsing polychondritis associated with recurrent oral ulceration . J Rheumatol. 1984;11:559-561. 7. Behçet H. Über rezidivierende, aphthose, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien . Dermatol Wochensch. 1937;105:1152-1157. 8. Mason RM, Barnes CG. Behçet's syndrome with arthritis . Ann Rheum Dis. 1969;28:95-103.Crossref 9. O'Duffy JD, Goldstein NP. Neurologic involvement in seven patients with Behçet's disease . Am J Med. 1976;61:170-178.Crossref 10. Shimizu T, Ehrlich GE, Inaba G, Hayashi K. Behçet disease (Behçet syndrome) . Semin Arthritis Rheum. 1979;8:223-260.Crossref 11. McAdam LP, O'Hanlon MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and review of the literature . Medicine (Baltimore). 1976;55:193-215.Crossref 12. Damiani JM, Levine HL. Relapsing polychondritis—report of ten cases . Laryngoscope. 1979;89:929-944.Crossref 13. Jorizzo JL, Hudson RD, Schmalstieg FC, et al. Behçet's syndrome: immune regulation, circulating immune complexes, neutrophil migration, and colchicine therapy . J Am Acad Dermatol. 1984;10:205-214.Crossref 14. Gamble CN, Wiesner KB, Shapiro EF, Boyer WJ. The immune complex pathogenesis of glomerulonephritis and pulmonary vasculitis in Behçet's disease . Am J Med. 1979;66:1031-1039.Crossref 15. Gupta RC, O'Duffy JD, McDuffie FC, Meurer M, Jordon RE. Circulatory immune complexes in active Behçet's disease . Clin Exp Immunol. 1978;34:213-218. 16. Lehner T, Almeida JD, Levinsky RJ. Damaged membrane fragments and immune complexes in the blood of patients with Behçet's syndrome . Clin Exp Immunol. 1978;34:206-212. 17. Lehner T, Welsh KL, Batchelor JR. Relationship of HLA phenotype to immunoglobulin class present in immune complexes from patients with Behçet's syndrome . Tissue Antigens. 1981; 17:357-361.Crossref 18. Valesini G, Picardo M, Pastore R, Pivetti P, Serafini U. Circulating immune complexes in Behçet's syndrome: purification, characterization and cross-reactivity studies . Clin Exp Immunol. 1981;44:522-527. 19. Williams BD, Lehner T. Immune complexes in Behçet's syndrome and recurrent oral ulceration . BMJ. 1977;1:1387-1389.Crossref 20. Jorizzo JL, Schmalstieg FC, Solomon AR Jr, et al. Thalidomide effects in Behçet's syndrome and pustular vasculitis . Arch Intern Med. 1986;146:878-881.Crossref 21. Jorizzo JL, Solomon AR, Cavallo T. Behçet's syndrome: immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up . Arch Pathol Lab Med. 1985;109:747-751. 22. Müller W, Lehner T. Quantitative electron microscopical analysis of leukocyte infiltration in oral ulcers of Behçet's syndrome . Br J Dermatol. 1982;106:535-544.Crossref 23. Jorizzo JL, Solomon AR, Zanolli MD, Leshin B. Neutrophilic vascular reactions . J Am Acad Dermatol. 1988;19:983-1005.Crossref 24. Herman JH, Dennis MV. Immunopathologic studies in relapsing polychondritis . J Clin Invest. 1973;52:549-558.Crossref 25. Rajapakse DA, Bywaters EGL. Cell-mediated immunity to cartilage proteoglycan in relapsing polychondritis . Clin Exp Immunol. 1974;16:497-502. 26. Giroux L, Paquin F, Guérard-Desjardins MJ, Lefaivre A. Relapsing polychondritis: an autoimmune disease . Semin Arthritis Rheum. 1983;13:182-187.Crossref 27. Foidart JM, Abe S, Martin GR, et al. Antibodies to type II collagen in relapsing polychondritis . N Engl J Med. 1978;299:1203-1207.Crossref 28. Meyer O, Cyna J, Dryll A, Cywiner-Golenzer C, Wassef M, Ryckewaert A. Relapsing polychondritis—pathogenic role of antinative collagen type II antibodies: a case report with immunological and pathological studies . J Rheumatol. 1981;8:820-824. 29. Ebringer R, Rook G, Swana GT, Bottazzo GF, Doniach D. Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases . Ann Rheum Dis. 1981; 40:473-479.Crossref 30. Trentham DE, Kammer GM, McCune J, David JR. Autoimmunity to collagen: a shared feature of psoriatic and rheumatoid arthritis . Arthritis Rheum. 1981;24:1363-1369.Crossref 31. Clague RB, Shaw MJ, Holt PJL. Incidence of serum antibodies to native type I and type II collagen in patients with inflammatory arthritis . Ann Rheum Dis. 1980;39:201-206.Crossref 32. Shaul SR, Schumacher HR. Relapsing polychondritis: electron microscope study of ear cartilage . Arthritis Rheum. 1975; 18:617-625.Crossref 33. Dryll A, Lansaman J, Meyer O, Bardin T, Ryckewaert A. Relapsing polychondritis: an ultrastructural study of elastic and collagen fibers degradation revealed by tannic acid . Virchows Arch A. 1981;390:109-119.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

The MAGIC Syndrome (Mouth and Genital Ulcers With Inflamed Cartilage)

Loading next page...
 
/lp/american-medical-association/the-magic-syndrome-mouth-and-genital-ulcers-with-inflamed-cartilage-5BdM5bZK1B
Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1990.01670310102016
Publisher site
See Article on Publisher Site

Abstract

Abstract • We describe a 42-year-old man with features of both Behçet's disease and relapsing polychondritis. The term MAGIC syndrome (mouth and genital ulcers with inflamed cartilage) has previously been used to describe similarly affected patients. We discuss the diagnostic criteria and pathogenetic mechanisms. (Arch Dermatol. 1990;126:940-944) References 1. Firestein GS, Gruber HE, Weisman MH, Zvaifler NJ. Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome . Am J Med. 1985;79:65-72.Crossref 2. Esdaile J, Hawkins D, Gold P, Freedman SO, Duguid WP. Vascular involvement in relapsing polychondritis . Can Med Assoc J. 1977;116:1019-1022. 3. McKay DAR, Watson PG, Lyne AJ. Relapsing polychondritis and eye disease . Br J Ophthalmol. 1974;58:600-605.Crossref 4. Menkes J, Siaud JR, Delbrieu F, Chouraki L, Bellaiche D, Delbarre F. Polychondrite chronique atrophiante: deux case, dont l'un avec cataracte et arterite des membres inferieurs . Ann Med Interne (Paris). 1970;121:895-904. 5. Saurat JH, Noury-Duperrat G, Delanoe J, Kernbaum S, Frottier J, Puisant A. Les manifestations cutanees de la polychondrite chronique atrophiante et leurs rapports avec l'aphtose . Ann Dermatol Venereol. 1972;102:145-156. 6. Prentice RL, Gatenby PA, Dagleish AG, Baston AB. Relapsing polychondritis associated with recurrent oral ulceration . J Rheumatol. 1984;11:559-561. 7. Behçet H. Über rezidivierende, aphthose, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien . Dermatol Wochensch. 1937;105:1152-1157. 8. Mason RM, Barnes CG. Behçet's syndrome with arthritis . Ann Rheum Dis. 1969;28:95-103.Crossref 9. O'Duffy JD, Goldstein NP. Neurologic involvement in seven patients with Behçet's disease . Am J Med. 1976;61:170-178.Crossref 10. Shimizu T, Ehrlich GE, Inaba G, Hayashi K. Behçet disease (Behçet syndrome) . Semin Arthritis Rheum. 1979;8:223-260.Crossref 11. McAdam LP, O'Hanlon MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and review of the literature . Medicine (Baltimore). 1976;55:193-215.Crossref 12. Damiani JM, Levine HL. Relapsing polychondritis—report of ten cases . Laryngoscope. 1979;89:929-944.Crossref 13. Jorizzo JL, Hudson RD, Schmalstieg FC, et al. Behçet's syndrome: immune regulation, circulating immune complexes, neutrophil migration, and colchicine therapy . J Am Acad Dermatol. 1984;10:205-214.Crossref 14. Gamble CN, Wiesner KB, Shapiro EF, Boyer WJ. The immune complex pathogenesis of glomerulonephritis and pulmonary vasculitis in Behçet's disease . Am J Med. 1979;66:1031-1039.Crossref 15. Gupta RC, O'Duffy JD, McDuffie FC, Meurer M, Jordon RE. Circulatory immune complexes in active Behçet's disease . Clin Exp Immunol. 1978;34:213-218. 16. Lehner T, Almeida JD, Levinsky RJ. Damaged membrane fragments and immune complexes in the blood of patients with Behçet's syndrome . Clin Exp Immunol. 1978;34:206-212. 17. Lehner T, Welsh KL, Batchelor JR. Relationship of HLA phenotype to immunoglobulin class present in immune complexes from patients with Behçet's syndrome . Tissue Antigens. 1981; 17:357-361.Crossref 18. Valesini G, Picardo M, Pastore R, Pivetti P, Serafini U. Circulating immune complexes in Behçet's syndrome: purification, characterization and cross-reactivity studies . Clin Exp Immunol. 1981;44:522-527. 19. Williams BD, Lehner T. Immune complexes in Behçet's syndrome and recurrent oral ulceration . BMJ. 1977;1:1387-1389.Crossref 20. Jorizzo JL, Schmalstieg FC, Solomon AR Jr, et al. Thalidomide effects in Behçet's syndrome and pustular vasculitis . Arch Intern Med. 1986;146:878-881.Crossref 21. Jorizzo JL, Solomon AR, Cavallo T. Behçet's syndrome: immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up . Arch Pathol Lab Med. 1985;109:747-751. 22. Müller W, Lehner T. Quantitative electron microscopical analysis of leukocyte infiltration in oral ulcers of Behçet's syndrome . Br J Dermatol. 1982;106:535-544.Crossref 23. Jorizzo JL, Solomon AR, Zanolli MD, Leshin B. Neutrophilic vascular reactions . J Am Acad Dermatol. 1988;19:983-1005.Crossref 24. Herman JH, Dennis MV. Immunopathologic studies in relapsing polychondritis . J Clin Invest. 1973;52:549-558.Crossref 25. Rajapakse DA, Bywaters EGL. Cell-mediated immunity to cartilage proteoglycan in relapsing polychondritis . Clin Exp Immunol. 1974;16:497-502. 26. Giroux L, Paquin F, Guérard-Desjardins MJ, Lefaivre A. Relapsing polychondritis: an autoimmune disease . Semin Arthritis Rheum. 1983;13:182-187.Crossref 27. Foidart JM, Abe S, Martin GR, et al. Antibodies to type II collagen in relapsing polychondritis . N Engl J Med. 1978;299:1203-1207.Crossref 28. Meyer O, Cyna J, Dryll A, Cywiner-Golenzer C, Wassef M, Ryckewaert A. Relapsing polychondritis—pathogenic role of antinative collagen type II antibodies: a case report with immunological and pathological studies . J Rheumatol. 1981;8:820-824. 29. Ebringer R, Rook G, Swana GT, Bottazzo GF, Doniach D. Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases . Ann Rheum Dis. 1981; 40:473-479.Crossref 30. Trentham DE, Kammer GM, McCune J, David JR. Autoimmunity to collagen: a shared feature of psoriatic and rheumatoid arthritis . Arthritis Rheum. 1981;24:1363-1369.Crossref 31. Clague RB, Shaw MJ, Holt PJL. Incidence of serum antibodies to native type I and type II collagen in patients with inflammatory arthritis . Ann Rheum Dis. 1980;39:201-206.Crossref 32. Shaul SR, Schumacher HR. Relapsing polychondritis: electron microscope study of ear cartilage . Arthritis Rheum. 1975; 18:617-625.Crossref 33. Dryll A, Lansaman J, Meyer O, Bardin T, Ryckewaert A. Relapsing polychondritis: an ultrastructural study of elastic and collagen fibers degradation revealed by tannic acid . Virchows Arch A. 1981;390:109-119.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1990

References