Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

THE LOCAL USE OF SULFANILAMIDE IN THE TREATMENT OF PERITONEAL INFECTIONS

THE LOCAL USE OF SULFANILAMIDE IN THE TREATMENT OF PERITONEAL INFECTIONS Two years after the report of Domagk1 in 1935 concerning the chemotherapeutic properties of azosulfamide, certain bacterial infections were commonly treated with sulfanilamide with excellent results. Given by mouth, by rectum or by hypodermoclysis at regular intervals, therapeutic blood and tissue concentrations could be maintained which had a definite bacteriostatic effect on certain organisms. In April 1937 Sinclair and Barker2 departed radically from the usual plan of administration of sulfanilamide and for the first time made use of high local concentrations of the drug for the treatment of localized infections. They used crushed sulfanilamide tablets in dental surgery, such as for infected operative wounds in the mouth, certain extractions, compound fractures and osteomyelitis of the mandible—with good results in the prophylaxis and treatment of infections. In July 1939 Jensen, Johnsrud and Nelson3 reported a series of compound fractures treated with local implantation of sulfanilamide. In this series http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

THE LOCAL USE OF SULFANILAMIDE IN THE TREATMENT OF PERITONEAL INFECTIONS

JAMA , Volume 118 (3) – Jan 17, 1942

Loading next page...
 
/lp/american-medical-association/the-local-use-of-sulfanilamide-in-the-treatment-of-peritoneal-ddDNmwNCSN

References (2)

Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1942.02830030007002
Publisher site
See Article on Publisher Site

Abstract

Two years after the report of Domagk1 in 1935 concerning the chemotherapeutic properties of azosulfamide, certain bacterial infections were commonly treated with sulfanilamide with excellent results. Given by mouth, by rectum or by hypodermoclysis at regular intervals, therapeutic blood and tissue concentrations could be maintained which had a definite bacteriostatic effect on certain organisms. In April 1937 Sinclair and Barker2 departed radically from the usual plan of administration of sulfanilamide and for the first time made use of high local concentrations of the drug for the treatment of localized infections. They used crushed sulfanilamide tablets in dental surgery, such as for infected operative wounds in the mouth, certain extractions, compound fractures and osteomyelitis of the mandible—with good results in the prophylaxis and treatment of infections. In July 1939 Jensen, Johnsrud and Nelson3 reported a series of compound fractures treated with local implantation of sulfanilamide. In this series

Journal

JAMAAmerican Medical Association

Published: Jan 17, 1942

There are no references for this article.