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The Intracarotid Amobarbital Sodium Procedure: False-positive Errors During Recognition Memory Assessment

The Intracarotid Amobarbital Sodium Procedure: False-positive Errors During Recognition Memory... Abstract • Memory performance during the intracarotid amobarbital sodium (Amytal sodium) procedure was examined in 40 patients as part of their diagnostic workup as candidates for epilepsy surgery. Free recall was significantly better following right hemisphere injection although no left/right difference was present during recognition assessment. However, the occurrence of false-positive (FP) recognition errors was significantly more frequent following left hemisphere injection. In all conditions, no relationship to seizure focus was observed. Patients with FP errors displayed poorer delayed verbal memory during baseline neuropsychological assessment compared with patients without FP errors. Data indicate an inverse relationship between FP errors and recent verbal memory function, and they suggest that impaired memory rather than failure to suppress incorrect responses secondary to poor self-monitoring capacity is responsible for the generation of FP and intrusion errors. References 1. Milner B: Psychological aspects of focal epilepsy and its neurosurgical management , in Purpura DP, Penry JK, Walter RD (eds): Advances in Neurology . New York, Raven Press, 1975, vol 8, pp 299-321. 2. Penfield W, Milner B: Memory deficit produced by bilateral lesion in the hippocampal zone . Arch Neurol Psychiatry 1958;79:475-497.Crossref 3. Rausch R: The neuropsychological evaluation , in Engel J (ed): Surgical Treatment of the Epilepsies . New York, Raven Press, 1987, pp 181-195. 4. Blume WT, Grabow JD, Darley FL, et al: Intracarotid amobarbital test of language and memory before temporal lobectomy for seizure control . Neurology 1973;23:812-819.Crossref 5. Buschke H, Fuld PA: Evaluating storage, retention, and retrieval in disordered memory and learning . Neurology 1974;11:1019-1025.Crossref 6. Rey A: L'examen psychologique dans les cas d'encephalopathie tramatique . Arch Psychol 1941;28:286-340. 7. Risse GL, Gazzaniga MS: Well-kept secrets of the right hemisphere: A carotid amytal study of restricted memory transfer . Neurology 1978;28:950-953.Crossref 8. Shindler AG, Caplan LR, Heir DB: Intrusions and perseverations . Brain Lang 1984;23:148-158.Crossref 9. Lee GP, Loring DW, Flanigin HF, et al: Electrical stimulation of the human hippocampus produces verbal intrusions during memory testing . Neuropsychologia 1988;26:623-627.Crossref 10. Lesser RP, Dinner DS, Luders H, et al: Memory for objects presented soon after intracarotid amobarbital sodium injections in patients with medically intractable complex partial seizures . Neurology 1986;36:895-899.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

The Intracarotid Amobarbital Sodium Procedure: False-positive Errors During Recognition Memory Assessment

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1989.00520390051015
Publisher site
See Article on Publisher Site

Abstract

Abstract • Memory performance during the intracarotid amobarbital sodium (Amytal sodium) procedure was examined in 40 patients as part of their diagnostic workup as candidates for epilepsy surgery. Free recall was significantly better following right hemisphere injection although no left/right difference was present during recognition assessment. However, the occurrence of false-positive (FP) recognition errors was significantly more frequent following left hemisphere injection. In all conditions, no relationship to seizure focus was observed. Patients with FP errors displayed poorer delayed verbal memory during baseline neuropsychological assessment compared with patients without FP errors. Data indicate an inverse relationship between FP errors and recent verbal memory function, and they suggest that impaired memory rather than failure to suppress incorrect responses secondary to poor self-monitoring capacity is responsible for the generation of FP and intrusion errors. References 1. Milner B: Psychological aspects of focal epilepsy and its neurosurgical management , in Purpura DP, Penry JK, Walter RD (eds): Advances in Neurology . New York, Raven Press, 1975, vol 8, pp 299-321. 2. Penfield W, Milner B: Memory deficit produced by bilateral lesion in the hippocampal zone . Arch Neurol Psychiatry 1958;79:475-497.Crossref 3. Rausch R: The neuropsychological evaluation , in Engel J (ed): Surgical Treatment of the Epilepsies . New York, Raven Press, 1987, pp 181-195. 4. Blume WT, Grabow JD, Darley FL, et al: Intracarotid amobarbital test of language and memory before temporal lobectomy for seizure control . Neurology 1973;23:812-819.Crossref 5. Buschke H, Fuld PA: Evaluating storage, retention, and retrieval in disordered memory and learning . Neurology 1974;11:1019-1025.Crossref 6. Rey A: L'examen psychologique dans les cas d'encephalopathie tramatique . Arch Psychol 1941;28:286-340. 7. Risse GL, Gazzaniga MS: Well-kept secrets of the right hemisphere: A carotid amytal study of restricted memory transfer . Neurology 1978;28:950-953.Crossref 8. Shindler AG, Caplan LR, Heir DB: Intrusions and perseverations . Brain Lang 1984;23:148-158.Crossref 9. Lee GP, Loring DW, Flanigin HF, et al: Electrical stimulation of the human hippocampus produces verbal intrusions during memory testing . Neuropsychologia 1988;26:623-627.Crossref 10. Lesser RP, Dinner DS, Luders H, et al: Memory for objects presented soon after intracarotid amobarbital sodium injections in patients with medically intractable complex partial seizures . Neurology 1986;36:895-899.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1989

References