Letters Published Online: January 23, 2017. doi:10.1001/jamapediatrics.2016.4689 S aureus–associated sepsis are urgently required. However, the evidence base to inform such protocols is sorely lacking. Im- Conflict of Interest Disclosures: None reported. portant questions about the epidemiology and clinical treat- 1. McMullan BJ, Bowen A, Blyth CC, et al. Epidemiology and mortality of Staphylococcus aureus bacteremia in Australian and New Zealand children. ment of staphylococcal bacteremia and sepsis remain, includ- JAMA Pediatr. 2016;170(10):979-986. ing optimal choice and duration of antibiotic therapy, benefit 2. Schlapbach LJ, Straney L, Alexander J, et al; ANZICS Paediatric Study Group. from combination therapy or antitoxin therapy, timing of in- Mortality related to invasive infections, sepsis, and septic shock in critically ill travenous to oral stepdown, and the role of further investiga- children in Australia and New Zealand, 2002-13: a multicentre retrospective tions such as echocardiography in children. cohort study. Lancet Infect Dis. 2015;15(1):46-54. In August 2016, we surveyed Australasian pediatric infec- 3. Saville BR, Berry SM. Efficiencies of platform clinical trials: a vision of the future. Clin Trials. 2016;13(3):358-366. tious diseases physicians on the treatment of S aureus infec- tions in children to understand clinical decision making in simple and complicated S aureus infection scenarios.
JAMA Pediatrics – American Medical Association
Published: Mar 30, 2017
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