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THE HISTAMINE TEST: WITH PARTICULAR REFERENCE TO THE DIAGNOSIS OF LEPROSY

THE HISTAMINE TEST: WITH PARTICULAR REFERENCE TO THE DIAGNOSIS OF LEPROSY Abstract Among the pharmacodynamic tests used for the study of the physiology of the circulation and peripheral innervation, the histamine test is the most important to the dermatosyphilologist. Its usefulness in the differential diagnosis of certain manifestations of leprosy, syringomyelia, polyneuritis and areas of anesthesia of central origin may be great. The histamine test, first used by Eppinger and Gutmann in 1913, was studied in relation to the peripheral circulation and its disturbances by Sir Thomas Lewis.1 This test has also been applied to the diagnosis of peripheral neural involvement by Tinel,2 Loesser3 and others and of leprosy by Pierini4 of Buenos Aires, Rodriguez and Plantilla5 of Manila and Schujman6 of Rosario. The test consists, according to Lewis, of intradermal injection of a 1: 1,000 solution of histamine phosphate, the reaction showing in the form of an immediate purpuric spot at the site of the References 1. Lewis, T.: The Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, Ltd., 1927. 2. Tinel, J.: Le système nerveux végétatif , Paris, Masson & Cie, 1937. 3. Loesser, L. H.: The Cutaneous Histamine Reaction as a Test of Peripheral Nerve Function , J. A. M. A. 110:2136 ( (June 25) ) 1938.Crossref 4. Pierini: Personal communication to the authors. 5. Rodriguez, J., and Plantilla, F. C.: The Histamine Test as an Aid in the Diagnosis of Early Leprosy , Leprosy Rev. 3:18 ( (Jan.) ) 1932. 6. Schujman, S.: Un nuevo signo diferencial entre siringomielia y lepra nerviosa , Rev. brasil. de leprol. 7:405 ( (Dec.) ) 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

THE HISTAMINE TEST: WITH PARTICULAR REFERENCE TO THE DIAGNOSIS OF LEPROSY

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Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1943.01500240066011
Publisher site
See Article on Publisher Site

Abstract

Abstract Among the pharmacodynamic tests used for the study of the physiology of the circulation and peripheral innervation, the histamine test is the most important to the dermatosyphilologist. Its usefulness in the differential diagnosis of certain manifestations of leprosy, syringomyelia, polyneuritis and areas of anesthesia of central origin may be great. The histamine test, first used by Eppinger and Gutmann in 1913, was studied in relation to the peripheral circulation and its disturbances by Sir Thomas Lewis.1 This test has also been applied to the diagnosis of peripheral neural involvement by Tinel,2 Loesser3 and others and of leprosy by Pierini4 of Buenos Aires, Rodriguez and Plantilla5 of Manila and Schujman6 of Rosario. The test consists, according to Lewis, of intradermal injection of a 1: 1,000 solution of histamine phosphate, the reaction showing in the form of an immediate purpuric spot at the site of the References 1. Lewis, T.: The Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, Ltd., 1927. 2. Tinel, J.: Le système nerveux végétatif , Paris, Masson & Cie, 1937. 3. Loesser, L. H.: The Cutaneous Histamine Reaction as a Test of Peripheral Nerve Function , J. A. M. A. 110:2136 ( (June 25) ) 1938.Crossref 4. Pierini: Personal communication to the authors. 5. Rodriguez, J., and Plantilla, F. C.: The Histamine Test as an Aid in the Diagnosis of Early Leprosy , Leprosy Rev. 3:18 ( (Jan.) ) 1932. 6. Schujman, S.: Un nuevo signo diferencial entre siringomielia y lepra nerviosa , Rev. brasil. de leprol. 7:405 ( (Dec.) ) 1939.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Jun 1, 1943

References