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The Heritable Nature of Dexamethasone-Induced Ocular Hypertension

The Heritable Nature of Dexamethasone-Induced Ocular Hypertension Abstract Clinically normal eyes were found to demonstrate different magnitudes of ocular hypertensive response when subjected to identical concentration, frequency, and duration of topical application of dexamethasone 21-phosphate. The search for a response measure which maximizes the detection of this heterogeneity led to the selection of the change in applanation pressure after four weeks of topical application of 0.1% dexamethasone three times daily. In the case of this measure, the hypothesis that the data represent a single homogeneous population had to be rejected at the 1% level of confidence.1 Using the above measure, 80 subjects with clinically normal eyes were shown to demonstrate three distinct and statistically different levels of response: low, intermediate, and high. Table 1 summarizes the characteristics of each level; ie, the range encountered in the sample, the mean, and the standard deviation, as well as the number of individuals and percent of the sample that demonstrated References 1. Armaly, M.F.: Statistical Attributes of the Steroid Hypertensive Response in the Clinically Normal Eye: I. The Demonstration of Three Levels of Response , Invest Ophthal 4:187, 1965. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Heritable Nature of Dexamethasone-Induced Ocular Hypertension

Archives of Ophthalmology , Volume 75 (1) – Jan 1, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1966.00970050034007
Publisher site
See Article on Publisher Site

Abstract

Abstract Clinically normal eyes were found to demonstrate different magnitudes of ocular hypertensive response when subjected to identical concentration, frequency, and duration of topical application of dexamethasone 21-phosphate. The search for a response measure which maximizes the detection of this heterogeneity led to the selection of the change in applanation pressure after four weeks of topical application of 0.1% dexamethasone three times daily. In the case of this measure, the hypothesis that the data represent a single homogeneous population had to be rejected at the 1% level of confidence.1 Using the above measure, 80 subjects with clinically normal eyes were shown to demonstrate three distinct and statistically different levels of response: low, intermediate, and high. Table 1 summarizes the characteristics of each level; ie, the range encountered in the sample, the mean, and the standard deviation, as well as the number of individuals and percent of the sample that demonstrated References 1. Armaly, M.F.: Statistical Attributes of the Steroid Hypertensive Response in the Clinically Normal Eye: I. The Demonstration of Three Levels of Response , Invest Ophthal 4:187, 1965.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jan 1, 1966

References

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