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The Hemolytic-Uremic Syndrome: Experience at a Center in the Midwest

The Hemolytic-Uremic Syndrome: Experience at a Center in the Midwest Abstract • Nineteen children with the hemolytic-uremic syndrome were treated in our hospital from 1968 to 1976. Seven were over 5 years of age. The disease occurred most often in the spring of the year. Lethargy was a prominent symptom in all patients, and seizures occurred in seven. Transfusion and dialysis were the most important treatment modalities. Heparin was used in four children and did not appear to affect the course of disease although three recovered. Thirteen of 15 children who did not receive heparin recovered. Irreversible renal failure occurred in three children, all of whom were in the older age group. Serious sequelae were rare in those who survived. (Am J Dis Child 132:59-62, 1978) References 1. Kaplan BS, Katz J, Krawitz S, et al: An analysis of the results of therapy in 67 cases of the hemolytic uremic syndrome . J Pediatr 78:420-425, 1971.Crossref 2. Wieringen PMV, Monnens LAH, Schretlen EDAM: Hemolytic-uremic syndrome-epidemiological and clinical study . Arch Dis Child 49:432-437, 1974.Crossref 3. Gianantonio C, Vitacco M, Mendilaharzu F, et al: The hemolytic uremic syndrome . Nephron 11:174-192, 1973.Crossref 4. Gasser C, Goutier E, Steck A, et al: Hamolytisch-uraemisch syndrom: Bilaterale nierenrin-dennekrosen bei akuten erworbenen hamolitischen anamien . Schweiz Med Wochenschr 85:905-909, 1955. 5. McLean MM, Hilton-Jones C, Sutherland DA: Haemolytic-uraemic syndrome: A report of an outbreak . Arch Dis Child 41:76-81, 1966.Crossref 6. Ray CG, Tucker VL, Harris DM, et al: Enteroviruses associated with the hemolytic uremic syndrome . Pediatrics 46:378-388, 1970. 7. Shumway CM, Terplan KL: Hemolytic anemia, thrombocytopenia and renal disease in childhood: The hemolytic uremic syndrome . Pediatr Clin North Am 11:577-591, 1964. 8. Gilchrist GW, Ekert H, Lieberman E, et al: Heparin therapy in the hemolytic uremic syndrome . Lancet 1:1123-1126, 1969.Crossref 9. Lieberman E: Hemolytic uremic syndrome . J Pediatr 80:1-16, 1972.Crossref 10. Tune BM, Leavitt TJ, Gribble TM: The hemolytic uremic syndrome in California: A review of 28 non-heparinized cases with long-term followup . J Pediatr 82:304-310, 1973.Crossref 11. Piel CF, Phibbs RH: The hemolytic-uremic syndrome . Pediatr Clin North Am 13:295-314, 1966. 12. Clarkson AR, Lawrence JR, Meadows R, et al: The haemolytic-uraemic syndrome in adults . Q J Med 39:227-239, 1970. 13. Sharpstone P, Evans RG, O'Shea M, et al: Haemolytic-uraemic syndrome: Survival after prolonged oliguria . Arch Dis Child 43:711-716, 1968.Crossref 14. Gianantonio C, Vitacco M, Mendilaharzu F, et al: The hemolytic uremic syndrome: Renal status of 76 patients at long-term followup . J Pediatr 72:757-765, 1968.Crossref 15. Rooney JC, Anderson R, Hopkins RJ: Clinical and pathological aspects of central nervous system involvement in the haemolytic-uraemic syndrome . Aust Paediatr J 7:28-33, 1971. 16. Meadows R: Central nervous system involvement in the hemolytic uremic syndrome . Dev Med Child Neurol 13:812-814, 1971. 17. McKay DB, Margaretten W: Disseminated intravascular coagulation in virus diseases . Arch Intern Med 120:129-152, 1967.Crossref 18. Kaplan BD, Keornhof HJ: Haemolytic-uraemic syndrome: Failure to demonstrate circulating endotoxin . Lancet 2:1424-1425, 1969.Crossref 19. Avalos JS, Vitacco M, Molinas F, et al: Coagulation studies in the hemolytic-uremic syndrome . J Pediatr 76:538-548, 1970.Crossref 20. Harker LA, Slichter SJ: Platelet and fibrinogen consumption in man . N Engl J Med 287:999-1005, 1972.Crossref 21. Katz J, Kravitz S, Sacks PV, et al: Platelet, erythrocyte and fibrinogen kinetics in the hemolytic-uremic syndrome of infancy . J Pediatr 83:739-748, 1973.Crossref 22. Gervais M, Richardson JV, Chiu J, et al: Immunofluorescent and histologic findings in the hemolytic-uremic syndrome . Pediatrics 47:352-359, 1971. 23. Austin TW, Ray CG: Coxsackie virus group B infection and the hemolytic uremic syndrome . J Infect Dis 127:698, 1973.Crossref 24. Dosik H, Tricarico F: Haemolytic-uremic syndrome following mumps vaccination . Lancet 1:247, 1970.Crossref 25. Chesney RW, Kaplan BD: Hemolytic uremic syndrome with shigellosis . J Pediatr 84:312-313, 1974.Crossref 26. Kaplan BS, Thompson PD, MacNab GM: Serum complement levels in haemolytic-uremic syndrome . Lancet 2:1505-1506, 1973.Crossref 27. McCoy RC, Abramowsky CW, Krueger R: The hemolytic-uremic syndrome with positive immunofluorescent studies . J Pediatr 85:170-174, 1974.Crossref 28. Castro A, Vitacco M: Immunologic studies of the chronic nephropathy following the hemolytic-uremic syndrome , abstracted. J Pediatr 89:324-325, 1976. 29. Proesman W, Eeckels R: Has heparin changed in the prognosis of the hemolytic uremic syndrome . Clin Nephrol 2:169-173, 1974. 30. Vitacco M, Avalos JS, Gianantonio CA: Heparin therapy in the hemolytic uremic syndrome . J Pediatr 83:271-275, 1973. 31. Arenson EB, August CS: Preliminary report: Treatment of the hemolytic-uremic syndrome with aspirin and dipyridamole . J Pediatr 86:957-961, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

The Hemolytic-Uremic Syndrome: Experience at a Center in the Midwest

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References (33)

Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120260061015
Publisher site
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Abstract

Abstract • Nineteen children with the hemolytic-uremic syndrome were treated in our hospital from 1968 to 1976. Seven were over 5 years of age. The disease occurred most often in the spring of the year. Lethargy was a prominent symptom in all patients, and seizures occurred in seven. Transfusion and dialysis were the most important treatment modalities. Heparin was used in four children and did not appear to affect the course of disease although three recovered. Thirteen of 15 children who did not receive heparin recovered. Irreversible renal failure occurred in three children, all of whom were in the older age group. Serious sequelae were rare in those who survived. (Am J Dis Child 132:59-62, 1978) References 1. Kaplan BS, Katz J, Krawitz S, et al: An analysis of the results of therapy in 67 cases of the hemolytic uremic syndrome . J Pediatr 78:420-425, 1971.Crossref 2. Wieringen PMV, Monnens LAH, Schretlen EDAM: Hemolytic-uremic syndrome-epidemiological and clinical study . Arch Dis Child 49:432-437, 1974.Crossref 3. Gianantonio C, Vitacco M, Mendilaharzu F, et al: The hemolytic uremic syndrome . Nephron 11:174-192, 1973.Crossref 4. Gasser C, Goutier E, Steck A, et al: Hamolytisch-uraemisch syndrom: Bilaterale nierenrin-dennekrosen bei akuten erworbenen hamolitischen anamien . Schweiz Med Wochenschr 85:905-909, 1955. 5. McLean MM, Hilton-Jones C, Sutherland DA: Haemolytic-uraemic syndrome: A report of an outbreak . Arch Dis Child 41:76-81, 1966.Crossref 6. Ray CG, Tucker VL, Harris DM, et al: Enteroviruses associated with the hemolytic uremic syndrome . Pediatrics 46:378-388, 1970. 7. Shumway CM, Terplan KL: Hemolytic anemia, thrombocytopenia and renal disease in childhood: The hemolytic uremic syndrome . Pediatr Clin North Am 11:577-591, 1964. 8. Gilchrist GW, Ekert H, Lieberman E, et al: Heparin therapy in the hemolytic uremic syndrome . Lancet 1:1123-1126, 1969.Crossref 9. Lieberman E: Hemolytic uremic syndrome . J Pediatr 80:1-16, 1972.Crossref 10. Tune BM, Leavitt TJ, Gribble TM: The hemolytic uremic syndrome in California: A review of 28 non-heparinized cases with long-term followup . J Pediatr 82:304-310, 1973.Crossref 11. Piel CF, Phibbs RH: The hemolytic-uremic syndrome . Pediatr Clin North Am 13:295-314, 1966. 12. Clarkson AR, Lawrence JR, Meadows R, et al: The haemolytic-uraemic syndrome in adults . Q J Med 39:227-239, 1970. 13. Sharpstone P, Evans RG, O'Shea M, et al: Haemolytic-uraemic syndrome: Survival after prolonged oliguria . Arch Dis Child 43:711-716, 1968.Crossref 14. Gianantonio C, Vitacco M, Mendilaharzu F, et al: The hemolytic uremic syndrome: Renal status of 76 patients at long-term followup . J Pediatr 72:757-765, 1968.Crossref 15. Rooney JC, Anderson R, Hopkins RJ: Clinical and pathological aspects of central nervous system involvement in the haemolytic-uraemic syndrome . Aust Paediatr J 7:28-33, 1971. 16. Meadows R: Central nervous system involvement in the hemolytic uremic syndrome . Dev Med Child Neurol 13:812-814, 1971. 17. McKay DB, Margaretten W: Disseminated intravascular coagulation in virus diseases . Arch Intern Med 120:129-152, 1967.Crossref 18. Kaplan BD, Keornhof HJ: Haemolytic-uraemic syndrome: Failure to demonstrate circulating endotoxin . Lancet 2:1424-1425, 1969.Crossref 19. Avalos JS, Vitacco M, Molinas F, et al: Coagulation studies in the hemolytic-uremic syndrome . J Pediatr 76:538-548, 1970.Crossref 20. Harker LA, Slichter SJ: Platelet and fibrinogen consumption in man . N Engl J Med 287:999-1005, 1972.Crossref 21. Katz J, Kravitz S, Sacks PV, et al: Platelet, erythrocyte and fibrinogen kinetics in the hemolytic-uremic syndrome of infancy . J Pediatr 83:739-748, 1973.Crossref 22. Gervais M, Richardson JV, Chiu J, et al: Immunofluorescent and histologic findings in the hemolytic-uremic syndrome . Pediatrics 47:352-359, 1971. 23. Austin TW, Ray CG: Coxsackie virus group B infection and the hemolytic uremic syndrome . J Infect Dis 127:698, 1973.Crossref 24. Dosik H, Tricarico F: Haemolytic-uremic syndrome following mumps vaccination . Lancet 1:247, 1970.Crossref 25. Chesney RW, Kaplan BD: Hemolytic uremic syndrome with shigellosis . J Pediatr 84:312-313, 1974.Crossref 26. Kaplan BS, Thompson PD, MacNab GM: Serum complement levels in haemolytic-uremic syndrome . Lancet 2:1505-1506, 1973.Crossref 27. McCoy RC, Abramowsky CW, Krueger R: The hemolytic-uremic syndrome with positive immunofluorescent studies . J Pediatr 85:170-174, 1974.Crossref 28. Castro A, Vitacco M: Immunologic studies of the chronic nephropathy following the hemolytic-uremic syndrome , abstracted. J Pediatr 89:324-325, 1976. 29. Proesman W, Eeckels R: Has heparin changed in the prognosis of the hemolytic uremic syndrome . Clin Nephrol 2:169-173, 1974. 30. Vitacco M, Avalos JS, Gianantonio CA: Heparin therapy in the hemolytic uremic syndrome . J Pediatr 83:271-275, 1973. 31. Arenson EB, August CS: Preliminary report: Treatment of the hemolytic-uremic syndrome with aspirin and dipyridamole . J Pediatr 86:957-961, 1975.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jan 1, 1978

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