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The Heart in Sickle Cell Anemia

The Heart in Sickle Cell Anemia Abstract • Sickle cell anemia is a lifelong debilitating disease often requiring multiple, frequent hospital admissions. Multiple organ systems become damaged, but the heart, although demonstrating abnormalities, is relatively spared. With increasing life span of these patients, cardiac dysfunction may become more prominent. Recent noninvasive and pathologic studies have given new information on the effect of this disease on the heart. This article reviews the current knowledge of cardiac involvement in sickle cell anemia. (Arch Intern Med 1982;142:1680-1684) References 1. Oliveira E, Gomez-Patino N: Falcemic cardiopathy: Report of a case. Am J Cardiol 1963;11:686-688.Crossref 2. Baroldi G: High resistance of human myocardium to shock and red blood cell aggregation (sludge). Cardiologia 1969;54:271-277.Crossref 3. Gerry JL, Bulkley BH, Hutchins GM: Clinicopathologic analysis of cardiac dysfunction in 52 patients with sickle cell anemia. Am J Cardiol 1978;42:211-216.Crossref 4. Lindsay J, Meshel JC, Patterson RH: The cardiovascular manifestations of sickle cell disease. Arch Intern Med 1974;133:643-651.Crossref 5. Rees AH, Stefadouros MA, Strong WB, et al: Left ventricular performance in children with homozygous sickle cell anemia. Br Heart J 1978;40:690-696.Crossref 6. Gerry JL, Baird MG, Fortuin NJ: Evaluation of left ventricular function in patients with sickle cell anemia. Am J Med 1976;60:968-972.Crossref 7. Val-Mejias J, Lee WK, Weisse AB, et al: Left ventricular performance during and after sickle cell crisis. Am Heart J 1979;97:585-591.Crossref 8. Covarrubias EA, Sheikh MU, Solanki DL, et al: Left ventricular function in sickle cell anemia: A noninvasive evaluation. South Med J 1980;73:342-344.Crossref 9. Hamash SM, Rucknagel DL: Clinical implications of recent advances in hemoglobin disorders. Med Clin North Am 1980;64:775-780. 10. Duke M, Abelmann WH: The hemodynamic response to chronic anemia. Circulation 1969;39:503-515.Crossref 11. Fowler NO, Holmes JC: Blood viscosity and cardiac output in acute experimental anemia. J Appl Physiol 1975;39:453-456. 12. Liang C, Huckabee WE: Mechanisms regulating the cardiac output response to cyanide infusion: A model of hypoxia. J Clin Invest 1973;52:3115-3128.Crossref 13. Varat MA, Adolph RJ, Fowler NO: Cardiovascular effects of anemia. Am Heart J 1972;83:415-426.Crossref 14. Graettinger JS, Parsons RL, Campbell JA: A correlation of clinical and hemodynamic studies in patients with mild and severe anemia with and without congestive failure. Ann Intern Med 1963;58:617-626.Crossref 15. Horne MK: Sickle cell anemia as a rheologic disease. Am J Med 1981;70:288-298.Crossref 16. Karayalcin G, Rosner F, Kim KY, et al: Sickle cell anemia: Clinical manifestations in 100 patients and review of the literature. Am J Med Sci 1975;269:51-68.Crossref 17. Louis-Gustave A, Louis-Gustave R: Signes cardiovasculaires de la drépanocytose. Arch Mal Coeur 1977;70:135-140. 18. Shubin H, Kaufman R, Shapiro M, et al: Cardiovascular findings in children with sickle cell anemia. Am J Cardiol 1960;6:875-885.Crossref 19. Winsor T, Burch GE: The electrocardiogram and cardiac state in active sickle cell disease. Am Heart J 1945;29:685-696.Crossref 20. Uzsoy NG: Cardiovascular findings in patients with sickle cell anemia. Am J Cardiol 1964;13:320-328.Crossref 21. Serjeant GR: Five-year follow-up of Jamaican adults with sickle cell anaemia. Br Med J 1975;3:20-21.Crossref 22. Seeler RA: Deaths in children with sickle cell anemia. Clin Pediatrics 1972;11:634-637.Crossref 23. Powers DR: Natural history of sickle cell disease: The first ten years. Semin Hematol 1975;12:267-285. 24. Craenen J, Kilman J, Hosier DM, et al: Mitral valve replacement in a child with sickle cell anemia. J Thorac Cardiovasc Surg 1972;63:797-799. 25. Moser KM, Shea JG: The relationship between pulmonary infarction, cor pulmonale and the sickle states. Am J Med 1967;22:561-565.Crossref 26. Leon MB, Borer JS, Bacharach SL, et al: Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload. N Engl J Med 1979;301:1143-1148.Crossref 27. Bromberg PA: Pulmonary aspects of sickle cell disease. Arch Intern Med 1974;133:652-657.Crossref 28. Oppenheimer EH, Esterley JR: Pulmonary changes in sickle cell disease. Am Rev Respir Dis 1971;103:858-859. 29. Moser KM, Luchsinger PC, Katz S: Pulmonary and cardiac function in sickle cell lung disease: Preliminary report. Dis Chest 1960;37:637-648.Crossref 30. Leight L, Snider TH, Clifford GO, et al: Hemodynamic studies in sickle cell anemia. Circulation 1954;10:653-662.Crossref 31. Rubler S, Fleischer RA: Sickle cell states and cardiomyopathy: Sudden death due to pulmonary thrombosis and infection. Am J Cardiol 1967;19:867-873.Crossref 32. Trubowitz S: The management of sickle cell anemia. Med Clin North Am 1976;60:933-944. 33. Lanzkowsky P, Shende A, Karayalcin G, et al: Partial exchange transfusion in sickle cell anemia. Am J Dis Child 1978;132:1206-1208.Crossref 34. Morrison JC, Wiser WL: The use of prophylactic partial exchange transfusion in pregnancies associated with sickle cell hemoglobinopathies. Obstet Gynecol 1976;48:516-520. 35. Sommer A, Kontras SB, Craenen JM: Partial exchange transfusion in sickle cell anemia complicated by heart disease. JAMA 1971;215:483-484.Crossref 36. Miller DM, Winslow RM, Klein HG, et al: Improved exercise performance after exchange transfusion in subjects with sickle cell anemia. Blood 1980;56:1127-1131. 37. Slutsky R, Karliner J, Ricci D, et al: Response of left ventricular volume to exercise in man assessed by radionuclide equilibrium angiography. Circulation 1979;60:565-571.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

The Heart in Sickle Cell Anemia

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340220096017
Publisher site
See Article on Publisher Site

Abstract

Abstract • Sickle cell anemia is a lifelong debilitating disease often requiring multiple, frequent hospital admissions. Multiple organ systems become damaged, but the heart, although demonstrating abnormalities, is relatively spared. With increasing life span of these patients, cardiac dysfunction may become more prominent. Recent noninvasive and pathologic studies have given new information on the effect of this disease on the heart. This article reviews the current knowledge of cardiac involvement in sickle cell anemia. (Arch Intern Med 1982;142:1680-1684) References 1. Oliveira E, Gomez-Patino N: Falcemic cardiopathy: Report of a case. Am J Cardiol 1963;11:686-688.Crossref 2. Baroldi G: High resistance of human myocardium to shock and red blood cell aggregation (sludge). Cardiologia 1969;54:271-277.Crossref 3. Gerry JL, Bulkley BH, Hutchins GM: Clinicopathologic analysis of cardiac dysfunction in 52 patients with sickle cell anemia. Am J Cardiol 1978;42:211-216.Crossref 4. Lindsay J, Meshel JC, Patterson RH: The cardiovascular manifestations of sickle cell disease. Arch Intern Med 1974;133:643-651.Crossref 5. Rees AH, Stefadouros MA, Strong WB, et al: Left ventricular performance in children with homozygous sickle cell anemia. Br Heart J 1978;40:690-696.Crossref 6. Gerry JL, Baird MG, Fortuin NJ: Evaluation of left ventricular function in patients with sickle cell anemia. Am J Med 1976;60:968-972.Crossref 7. Val-Mejias J, Lee WK, Weisse AB, et al: Left ventricular performance during and after sickle cell crisis. Am Heart J 1979;97:585-591.Crossref 8. Covarrubias EA, Sheikh MU, Solanki DL, et al: Left ventricular function in sickle cell anemia: A noninvasive evaluation. South Med J 1980;73:342-344.Crossref 9. Hamash SM, Rucknagel DL: Clinical implications of recent advances in hemoglobin disorders. Med Clin North Am 1980;64:775-780. 10. Duke M, Abelmann WH: The hemodynamic response to chronic anemia. Circulation 1969;39:503-515.Crossref 11. Fowler NO, Holmes JC: Blood viscosity and cardiac output in acute experimental anemia. J Appl Physiol 1975;39:453-456. 12. Liang C, Huckabee WE: Mechanisms regulating the cardiac output response to cyanide infusion: A model of hypoxia. J Clin Invest 1973;52:3115-3128.Crossref 13. Varat MA, Adolph RJ, Fowler NO: Cardiovascular effects of anemia. Am Heart J 1972;83:415-426.Crossref 14. Graettinger JS, Parsons RL, Campbell JA: A correlation of clinical and hemodynamic studies in patients with mild and severe anemia with and without congestive failure. Ann Intern Med 1963;58:617-626.Crossref 15. Horne MK: Sickle cell anemia as a rheologic disease. Am J Med 1981;70:288-298.Crossref 16. Karayalcin G, Rosner F, Kim KY, et al: Sickle cell anemia: Clinical manifestations in 100 patients and review of the literature. Am J Med Sci 1975;269:51-68.Crossref 17. Louis-Gustave A, Louis-Gustave R: Signes cardiovasculaires de la drépanocytose. Arch Mal Coeur 1977;70:135-140. 18. Shubin H, Kaufman R, Shapiro M, et al: Cardiovascular findings in children with sickle cell anemia. Am J Cardiol 1960;6:875-885.Crossref 19. Winsor T, Burch GE: The electrocardiogram and cardiac state in active sickle cell disease. Am Heart J 1945;29:685-696.Crossref 20. Uzsoy NG: Cardiovascular findings in patients with sickle cell anemia. Am J Cardiol 1964;13:320-328.Crossref 21. Serjeant GR: Five-year follow-up of Jamaican adults with sickle cell anaemia. Br Med J 1975;3:20-21.Crossref 22. Seeler RA: Deaths in children with sickle cell anemia. Clin Pediatrics 1972;11:634-637.Crossref 23. Powers DR: Natural history of sickle cell disease: The first ten years. Semin Hematol 1975;12:267-285. 24. Craenen J, Kilman J, Hosier DM, et al: Mitral valve replacement in a child with sickle cell anemia. J Thorac Cardiovasc Surg 1972;63:797-799. 25. Moser KM, Shea JG: The relationship between pulmonary infarction, cor pulmonale and the sickle states. Am J Med 1967;22:561-565.Crossref 26. Leon MB, Borer JS, Bacharach SL, et al: Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload. N Engl J Med 1979;301:1143-1148.Crossref 27. Bromberg PA: Pulmonary aspects of sickle cell disease. Arch Intern Med 1974;133:652-657.Crossref 28. Oppenheimer EH, Esterley JR: Pulmonary changes in sickle cell disease. Am Rev Respir Dis 1971;103:858-859. 29. Moser KM, Luchsinger PC, Katz S: Pulmonary and cardiac function in sickle cell lung disease: Preliminary report. Dis Chest 1960;37:637-648.Crossref 30. Leight L, Snider TH, Clifford GO, et al: Hemodynamic studies in sickle cell anemia. Circulation 1954;10:653-662.Crossref 31. Rubler S, Fleischer RA: Sickle cell states and cardiomyopathy: Sudden death due to pulmonary thrombosis and infection. Am J Cardiol 1967;19:867-873.Crossref 32. Trubowitz S: The management of sickle cell anemia. Med Clin North Am 1976;60:933-944. 33. Lanzkowsky P, Shende A, Karayalcin G, et al: Partial exchange transfusion in sickle cell anemia. Am J Dis Child 1978;132:1206-1208.Crossref 34. Morrison JC, Wiser WL: The use of prophylactic partial exchange transfusion in pregnancies associated with sickle cell hemoglobinopathies. Obstet Gynecol 1976;48:516-520. 35. Sommer A, Kontras SB, Craenen JM: Partial exchange transfusion in sickle cell anemia complicated by heart disease. JAMA 1971;215:483-484.Crossref 36. Miller DM, Winslow RM, Klein HG, et al: Improved exercise performance after exchange transfusion in subjects with sickle cell anemia. Blood 1980;56:1127-1131. 37. Slutsky R, Karliner J, Ricci D, et al: Response of left ventricular volume to exercise in man assessed by radionuclide equilibrium angiography. Circulation 1979;60:565-571.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1982

References