NEUROLOGICAL REVIEW Charting a Course for Genetic Discovery in Neurological Diseases John Hardy, PhD; Andrew Singleton, PhD hole-genome association analyses have begun to yield confirmed findings for ge- netic risk variants for complex disease. As the first reports of its application to neu- rological disease are described, we review this progress, explain the principles of W the analysis, and discuss what the future is likely to be in this exciting area. Arch Neurol. 2008;65(3):319-321 The human genome draft sequence re- 15 years to find them: candidate gene as- 1,2 leased in 2001 was a consensus se- sociation studies and affected family mem- quence based on the stitching together of ber (sibpair) linkage studies. While each has DNA sequences from clones derived from had limited successes, progress in general many individuals; at best, this corre- had been disappointing. sponded to an imperfect sketch of the hu- This last year, finally, the drought in ge- man sequence and certainly represented netic findings for complex diseases has no one person. The immediate utility of ended and a deluge of clear disease asso- the human draft DNA sequence was that ciations has been reported. The reasons for it provided a map to allow
JAMA Neurology – American Medical Association
Published: Mar 1, 2008
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera