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The Formation of Crystals in Ganciclovir Used for Intraocular Injection

The Formation of Crystals in Ganciclovir Used for Intraocular Injection Abstract Ganciclovir sodium is often administered in intraocular doses of 200 to 2000 μg for the treatment of cytomegalovirus retinitis.1 The higher dose has been advocated because it is believed that it may be more efficacious and result in a reduced risk of cytomegalovirus resistance.1 Ganciclovir is commercially available in a 500-mg vial and, therefore, further dilution is required for intraocular injection. It is standard practice for pharmacies to refrigerate reconstituted ganciclovir for future injections.2 Sterile water is used for reconstitution because paraben preservatives in bacteriostatic water for injection may cause precipitation. Stability is not a problem because reconstituted ganciclovir can be stored for up to 60 days at 4°C.2,3 We report the appearance of crystals (Figure) in syringes of ganciclovir sodium, 2000 μg/0.05 mL, after storage for as little as 24 hours in the refrigerator at 4°C. The crystals dissolve within 4 hours at room temperature. References 1. Young SH, Morlet N, Heery S, et al. High dose intravitreal ganciclovir in the treatment of cytomegalovirus retinitis . Med J Aust . 1992;157:370-373. 2. Fiscella R, Aramwit P. Ganciclovir for intravitreal injection . Am J Health Syst Pharm . 1995;52:422. 3. Trissel LA. Handbook on Injectable Drugs . 8th ed. Bethesda, Md: American Society of Hospital Pharmacists; 1994. 4. AHFS Drug Information 1995 . Bethesda, Md: American Society of Hospital Pharmacists; 1995. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Formation of Crystals in Ganciclovir Used for Intraocular Injection

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1997.01100160115034
Publisher site
See Article on Publisher Site

Abstract

Abstract Ganciclovir sodium is often administered in intraocular doses of 200 to 2000 μg for the treatment of cytomegalovirus retinitis.1 The higher dose has been advocated because it is believed that it may be more efficacious and result in a reduced risk of cytomegalovirus resistance.1 Ganciclovir is commercially available in a 500-mg vial and, therefore, further dilution is required for intraocular injection. It is standard practice for pharmacies to refrigerate reconstituted ganciclovir for future injections.2 Sterile water is used for reconstitution because paraben preservatives in bacteriostatic water for injection may cause precipitation. Stability is not a problem because reconstituted ganciclovir can be stored for up to 60 days at 4°C.2,3 We report the appearance of crystals (Figure) in syringes of ganciclovir sodium, 2000 μg/0.05 mL, after storage for as little as 24 hours in the refrigerator at 4°C. The crystals dissolve within 4 hours at room temperature. References 1. Young SH, Morlet N, Heery S, et al. High dose intravitreal ganciclovir in the treatment of cytomegalovirus retinitis . Med J Aust . 1992;157:370-373. 2. Fiscella R, Aramwit P. Ganciclovir for intravitreal injection . Am J Health Syst Pharm . 1995;52:422. 3. Trissel LA. Handbook on Injectable Drugs . 8th ed. Bethesda, Md: American Society of Hospital Pharmacists; 1994. 4. AHFS Drug Information 1995 . Bethesda, Md: American Society of Hospital Pharmacists; 1995.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1997

References