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The Eye in Bone Marrow Transplantation: I. Clinical Study

The Eye in Bone Marrow Transplantation: I. Clinical Study Abstract • A prospective study of 45 patients undergoing bone marrow transplantation included full ocular examination and pretransplant and posttransplant conjunctival biopsies. The major finding was the development of a severe keratoconjunctivitis sicca syndrome that developed in 20 of the 45 patients and closely correlated with the occurrence of acute graft-v-host disease (GVHD). An acute pseudomembranous conjunctivitis in the fulminant stage of acute GVHD developed in six patients. A further ten patients made up a retrospective assessment of bone marrow transplantation and confirmed these clinical findings. References 1. Santos GW: Bone marrow transplantation , in Stollerman GH (ed): Advances in Internal Medicine . Chicago, Year Book Medical Publishers, 1979, vol 24, pp 157-182. 2. Santos GW, Kaizer H: Bone marrow transplantation in acute leukemia . Semin Hematol 1982;19:227-239. 3. Tutschka PJ, Bortin MM: Graft versus host disease . Transplant Proc 1981;13:1267-1269. 4. Gress RE, Tutschka PJ, Beschorner WE, et al: Chronic graft-versus-host disease: Baltimore experience . Exp Hematol 1974;61( (suppl 71) ):100. 5. Sullivan KM, Shulman HM, Storb R, et al: Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression . Blood 1981;57:267-276. 6. Lawley TJ, Peck GL, Moutsopoulos HM, et al: Scleroderma, Sjögren-like syndrome and chronic graft-versus-host disease . Ann Intern Med 1977;87:707-709.Crossref 7. Franklin RM, Kenyon KR, Tutschka PJ, et al: Ocular manifestations of graft-vs-host disease . Ophthalmology 1983;90:4-13.Crossref 8. Van Bijsterveld OP: Diagnostic tests in the sicca syndrome . Arch Ophthalmol 1969;82:10-14.Crossref 9. Jones LT: The lacrimal secretory system and its treatment . Am J Ophthalmol 1966;62:47-60. 10. Glucksberg H, Storb R, Fefer A, et al: Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A matched sibling donors . Transplantation 1974;18:295-304.Crossref 11. Lerner KG, Kao GF, Storb R, et al: Histopathology of graft-versus-host reaction (GVHR) in human recipients of marrow from HLAmatched sibling donors . Transplant Proc 1974; 6:367-371. 12. Lichter AS, Tutschka PJ, Wharam MD, et al: The use of fractionated radiotherapy as preparation for allogeneic bone marrow transplantation . Transplant Proc 1979;11:1492-1494. 13. Tutschka PJ, Santos GW, Elfenbein GJ: Marrow transplantation in acute leukemia following busulfan and cyclophosphamide . Haematol Bluttransfus 1981;25:375-380. 14. Tutschka PJ, Elfenbein GJ, Sensenbrenner LL, et al: Preparative regimens for marrow transplantation in acute leukemia and aplastic anemia: Baltimore experience . Am J Hematol Oncol 1980;2:363-370. 15. Tutschka PJ, Santos GW, Elfenbein GJ, et al: Allogeneic bone marrow transplantation as therapy for leukemia: Baltimore experience , in O'Kunewick JP, Meridith RF (eds): Graft Versus Leukemia in Man and Animal Models . West Palm Beach, Fla, CRC Press Inc, 1981, pp 45-52. 16. Thomas ED, Storb R, Clift RA, et al: Bone-marrow transplantation. Parts I and II . N Engl J Med 1975;292:832-843, 895-902.Crossref 17. Elfenbein GJ, Saral R: Infectious disease during immune recovery after bone marrow transplantation , in Allen JE (ed): Infection and the Compromised Host: Clinical Correlations and Therapeutic Approaches , ed 2. Baltimore, Williams & Wilkins Co, 1981, pp 157-196. 18. Slavin RE, Santos GW: The graft-versushost reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features, and implications . Clin Immunol Immunopathol 1973;1:472-498.Crossref 19. Shulman HM, Sullivan KM, Weiden PL, et al: Chronic graft-versus-host syndrome in man: A long-term clinicopathological study of 20 Seattle patients . Am J Med 1980;69:204-217.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Eye in Bone Marrow Transplantation: I. Clinical Study

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1983.01040010580010
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Abstract

Abstract • A prospective study of 45 patients undergoing bone marrow transplantation included full ocular examination and pretransplant and posttransplant conjunctival biopsies. The major finding was the development of a severe keratoconjunctivitis sicca syndrome that developed in 20 of the 45 patients and closely correlated with the occurrence of acute graft-v-host disease (GVHD). An acute pseudomembranous conjunctivitis in the fulminant stage of acute GVHD developed in six patients. A further ten patients made up a retrospective assessment of bone marrow transplantation and confirmed these clinical findings. References 1. Santos GW: Bone marrow transplantation , in Stollerman GH (ed): Advances in Internal Medicine . Chicago, Year Book Medical Publishers, 1979, vol 24, pp 157-182. 2. Santos GW, Kaizer H: Bone marrow transplantation in acute leukemia . Semin Hematol 1982;19:227-239. 3. Tutschka PJ, Bortin MM: Graft versus host disease . Transplant Proc 1981;13:1267-1269. 4. Gress RE, Tutschka PJ, Beschorner WE, et al: Chronic graft-versus-host disease: Baltimore experience . Exp Hematol 1974;61( (suppl 71) ):100. 5. Sullivan KM, Shulman HM, Storb R, et al: Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression . Blood 1981;57:267-276. 6. Lawley TJ, Peck GL, Moutsopoulos HM, et al: Scleroderma, Sjögren-like syndrome and chronic graft-versus-host disease . Ann Intern Med 1977;87:707-709.Crossref 7. Franklin RM, Kenyon KR, Tutschka PJ, et al: Ocular manifestations of graft-vs-host disease . Ophthalmology 1983;90:4-13.Crossref 8. Van Bijsterveld OP: Diagnostic tests in the sicca syndrome . Arch Ophthalmol 1969;82:10-14.Crossref 9. Jones LT: The lacrimal secretory system and its treatment . Am J Ophthalmol 1966;62:47-60. 10. Glucksberg H, Storb R, Fefer A, et al: Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A matched sibling donors . Transplantation 1974;18:295-304.Crossref 11. Lerner KG, Kao GF, Storb R, et al: Histopathology of graft-versus-host reaction (GVHR) in human recipients of marrow from HLAmatched sibling donors . Transplant Proc 1974; 6:367-371. 12. Lichter AS, Tutschka PJ, Wharam MD, et al: The use of fractionated radiotherapy as preparation for allogeneic bone marrow transplantation . Transplant Proc 1979;11:1492-1494. 13. Tutschka PJ, Santos GW, Elfenbein GJ: Marrow transplantation in acute leukemia following busulfan and cyclophosphamide . Haematol Bluttransfus 1981;25:375-380. 14. Tutschka PJ, Elfenbein GJ, Sensenbrenner LL, et al: Preparative regimens for marrow transplantation in acute leukemia and aplastic anemia: Baltimore experience . Am J Hematol Oncol 1980;2:363-370. 15. Tutschka PJ, Santos GW, Elfenbein GJ, et al: Allogeneic bone marrow transplantation as therapy for leukemia: Baltimore experience , in O'Kunewick JP, Meridith RF (eds): Graft Versus Leukemia in Man and Animal Models . West Palm Beach, Fla, CRC Press Inc, 1981, pp 45-52. 16. Thomas ED, Storb R, Clift RA, et al: Bone-marrow transplantation. Parts I and II . N Engl J Med 1975;292:832-843, 895-902.Crossref 17. Elfenbein GJ, Saral R: Infectious disease during immune recovery after bone marrow transplantation , in Allen JE (ed): Infection and the Compromised Host: Clinical Correlations and Therapeutic Approaches , ed 2. Baltimore, Williams & Wilkins Co, 1981, pp 157-196. 18. Slavin RE, Santos GW: The graft-versushost reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features, and implications . Clin Immunol Immunopathol 1973;1:472-498.Crossref 19. Shulman HM, Sullivan KM, Weiden PL, et al: Chronic graft-versus-host syndrome in man: A long-term clinicopathological study of 20 Seattle patients . Am J Med 1980;69:204-217.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Apr 1, 1983

References

  • Advances in Internal Medicine
    Santos GW
  • Bone marrow transplantation in acute leukemia
    Santos GW, Kaizer H
  • Graft versus host disease
    Tutschka PJ, Bortin MM
  • Chronic graft-versus-host disease: Baltimore experience
    Gress RE, Tutschka PJ, Beschorner WE, et al
  • Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression
    Sullivan KM, Shulman HM, Storb R, et al
  • Scleroderma, Sjögren-like syndrome and chronic graft-versus-host disease
    Lawley TJ, Peck GL, Moutsopoulos HM, et al
  • Ocular manifestations of graft-vs-host disease
    Franklin RM, Kenyon KR, Tutschka PJ, et al
  • Diagnostic tests in the sicca syndrome
    Van Bijsterveld OP
  • The lacrimal secretory system and its treatment
    Jones LT
  • Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A matched sibling donors
    Glucksberg H, Storb R, Fefer A, et al
  • Histopathology of graft-versus-host reaction (GVHR) in human recipients of marrow from HLAmatched sibling donors
    Lerner KG, Kao GF, Storb R, et al
  • The use of fractionated radiotherapy as preparation for allogeneic bone marrow transplantation
    Lichter AS, Tutschka PJ, Wharam MD, et al
  • Marrow transplantation in acute leukemia following busulfan and cyclophosphamide
    Tutschka PJ, Santos GW, Elfenbein GJ
  • Preparative regimens for marrow transplantation in acute leukemia and aplastic anemia: Baltimore experience
    Tutschka PJ, Elfenbein GJ, Sensenbrenner LL, et al
  • Graft Versus Leukemia in Man and Animal Models
    Tutschka PJ, Santos GW, Elfenbein GJ, et al
  • Bone-marrow transplantation. Parts I and II
    Thomas ED, Storb R, Clift RA, et al
  • Infection and the Compromised Host: Clinical Correlations and Therapeutic Approaches
    Elfenbein GJ, Saral R
  • The graft-versushost reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features, and implications
    Slavin RE, Santos GW
  • Chronic graft-versus-host syndrome in man: A long-term clinicopathological study of 20 Seattle patients
    Shulman HM, Sullivan KM, Weiden PL, et al