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The Experimental Toxicology of Griseofulvin

The Experimental Toxicology of Griseofulvin Abstract In 1956 our colleague, Dr. A. R. Martin,4 discovered in these laboratories that systemically administered griseofulvin produced dramatic cure in superficial mycotic infections of the guinea pig skin. It therefore became necessary to determine whether griseofulvin was safe enough to administer to man. This paper reports the investigations carried out to this end. These have already been briefly reported elsewhere (Paget and Walpole,5 1958). Methods Griseofulvin.— All the griseofulvin used in these experiments was obtained from Messrs. Glaxo as a white crystalline powder. Animals dosed orally received appropriate doses as a 4% suspension of this material in 0.5% Tween 80. The doses were given by stomach tube once daily five days a week. For parenteral, and particularly for intravenous, administration it is necessary to produce a fine-particle-size suspension. For this purpose dry griseofulvin powder was finely ground in a pestle and mortar and then suspended in 0.5% Tween References 1. Blank, H., and Roth, F. J.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259, 1959.Crossref 2. Burke, W. T.; Brotherston, G., and Harris, C.: An Improved Technique for Obtaining Bone Marrow Smears from the Rat , Am. J. Clin. Path. 25:1226 ( (Oct.) ) 1955. 3. Harde, E.: Occurrence of Tumours in Mice During Prolonged Treatment with Colchicine , International Cancer Congress, 3d Congress , p. 126, 1939. 4. Martin, A. R.: The Systemic and Local Treatment of Experimental Dermatophytosis with Griseofulvin , J. Invest. Dermat. 32:525 ( (April) ) 1959.Crossref 5. Paget, G. E., and Walpole, A. L.: Some Cytological Effects of Griseofulvin , Nature, London 182:1320 ( (Nov. 8) ) 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Experimental Toxicology of Griseofulvin

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730050106018
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1956 our colleague, Dr. A. R. Martin,4 discovered in these laboratories that systemically administered griseofulvin produced dramatic cure in superficial mycotic infections of the guinea pig skin. It therefore became necessary to determine whether griseofulvin was safe enough to administer to man. This paper reports the investigations carried out to this end. These have already been briefly reported elsewhere (Paget and Walpole,5 1958). Methods Griseofulvin.— All the griseofulvin used in these experiments was obtained from Messrs. Glaxo as a white crystalline powder. Animals dosed orally received appropriate doses as a 4% suspension of this material in 0.5% Tween 80. The doses were given by stomach tube once daily five days a week. For parenteral, and particularly for intravenous, administration it is necessary to produce a fine-particle-size suspension. For this purpose dry griseofulvin powder was finely ground in a pestle and mortar and then suspended in 0.5% Tween References 1. Blank, H., and Roth, F. J.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259, 1959.Crossref 2. Burke, W. T.; Brotherston, G., and Harris, C.: An Improved Technique for Obtaining Bone Marrow Smears from the Rat , Am. J. Clin. Path. 25:1226 ( (Oct.) ) 1955. 3. Harde, E.: Occurrence of Tumours in Mice During Prolonged Treatment with Colchicine , International Cancer Congress, 3d Congress , p. 126, 1939. 4. Martin, A. R.: The Systemic and Local Treatment of Experimental Dermatophytosis with Griseofulvin , J. Invest. Dermat. 32:525 ( (April) ) 1959.Crossref 5. Paget, G. E., and Walpole, A. L.: Some Cytological Effects of Griseofulvin , Nature, London 182:1320 ( (Nov. 8) ) 1958.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: May 1, 1960

References