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THE ETIOLOGY OF CHRONIC ULCERATIVE COLITIS: EXPERIMENTAL STUDIES WITH SUGGESTIONS FOR A MORE RATIONAL FORM OF TREATMENT

THE ETIOLOGY OF CHRONIC ULCERATIVE COLITIS: EXPERIMENTAL STUDIES WITH SUGGESTIONS FOR A MORE... Abstract A year ago we believed we had isolated the organism responsible for at least a prominent part in the cause of chronic ulcerative colitis of the so-called idiopathic type.1 The organism was obtained with sterile swabs through the proctoscope from the depths of an ulcer of the colon, after the latter had been thoroughly cleansed by repeated washings and the top of the ulcer had been carefully wiped with a preliminary swab. Cultures of stools failed to yield the organism but in cultures of the rectal discharge of mucus, pus and blood it was often found as the vastly predominating bacterium. The material obtained was cultured immediately in warm dextrose brain broth,2 blood agar and lactose agar and incubated for twenty-four hours. All mediums were titrated to a pH 7.4. The organism isolated in this way as the predominating bacterium and often in pure cultures is a gram-positive, lancet shaped References 1. Bargen, J. A.: Experimental Studies on the Etiology of Chronic Ulcerative Colitis , J. A. M. A. 83:332-336 ( (Aug. 2) ) 1924.Crossref 2. Rosenow, E. C.: Studies on Elective Localization, Focal Infection with Special Reference to Oral Sepsis , J. Dent. Res. 1:205-268, 1919.Crossref 3. McCarrison, Robert: Studies in Deficiency Disease , London, Frowde, Hodder and Stoughton, 1921. 4. Logan, A. H.: Three Cases of Ulcerative Colitis Cured with Iodin , Med. Clin. N. A. 7:105-112 ( (July) ) 1923. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE ETIOLOGY OF CHRONIC ULCERATIVE COLITIS: EXPERIMENTAL STUDIES WITH SUGGESTIONS FOR A MORE RATIONAL FORM OF TREATMENT

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Publisher
American Medical Association
Copyright
Copyright © 1925 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1925.00120180070007
Publisher site
See Article on Publisher Site

Abstract

Abstract A year ago we believed we had isolated the organism responsible for at least a prominent part in the cause of chronic ulcerative colitis of the so-called idiopathic type.1 The organism was obtained with sterile swabs through the proctoscope from the depths of an ulcer of the colon, after the latter had been thoroughly cleansed by repeated washings and the top of the ulcer had been carefully wiped with a preliminary swab. Cultures of stools failed to yield the organism but in cultures of the rectal discharge of mucus, pus and blood it was often found as the vastly predominating bacterium. The material obtained was cultured immediately in warm dextrose brain broth,2 blood agar and lactose agar and incubated for twenty-four hours. All mediums were titrated to a pH 7.4. The organism isolated in this way as the predominating bacterium and often in pure cultures is a gram-positive, lancet shaped References 1. Bargen, J. A.: Experimental Studies on the Etiology of Chronic Ulcerative Colitis , J. A. M. A. 83:332-336 ( (Aug. 2) ) 1924.Crossref 2. Rosenow, E. C.: Studies on Elective Localization, Focal Infection with Special Reference to Oral Sepsis , J. Dent. Res. 1:205-268, 1919.Crossref 3. McCarrison, Robert: Studies in Deficiency Disease , London, Frowde, Hodder and Stoughton, 1921. 4. Logan, A. H.: Three Cases of Ulcerative Colitis Cured with Iodin , Med. Clin. N. A. 7:105-112 ( (July) ) 1923.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1925

References