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The Eosinophil and the Lung

The Eosinophil and the Lung Abstract • Current concepts regarding the morphology, constituents, distribution, and kinetics of the eosinophil allow an expanded understanding of the eosinophil's function in health and disease. In particular, certain eosinophil constituents may have beneficial effects (modulation of mast cell-dependent reactions and helminthotoxic properties), while others may produce detrimental effects (tissue destruction). Eosinophils may be clinically important in obstructive and infiltrative pulmonary diseases. In obstructive disease, a peripheral eosinophilia indicates reversibility, and the magnitude of the peripheral eosinophil count correlates with the severity of the reversible obstruction. Concerning infiltrative pulmonary disease, an updated classification of pulmonary infiltrates with eosinophilia, which is based on recognizable causes and syndromes, is presented, and allergic bronchopulmonary aspergillosis, chronic eosinophilic pneumonia, drug reactions, the hypereosinophilic syndrome, parasitic infestations, and the Churg-Strauss syndrome are specifically considered. (Arch Intern Med 1982;142:1515-1519) References 1. Archer GT, Hirsch JG: Isolation of granules from eosinophil leukocytes and study of their enzyme content. J Exp Med 1963;118:277-285.Crossref 2. Zeiger RS, Yordin DL, Colten HR: Histamine metabolism: II. Cellular and subcellular localization of the catabolic enzymes, histaminase and histamine methyl transferase in human leukocytes. J Allergy Clin Immunol 1976;58:172-179.Crossref 3. Venge P, Roxin LE, Olssom I: Radioimmunoassay of human eosinophil cationic protein. Br J Haematol 1977;37:331-335.Crossref 4. Gleich GJ, Loegering DA, Marin KG, et al: Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. J Clin Invest 1976;57:633-640.Crossref 5. Durack DT, Ackerman SJ, Loegering DA, et al: Purification of human eosinophil-derived neurotoxin. Proc Natl Acad Sci USA 1981;78:5165-5169.Crossref 6. Parmley RT, Spicer SS: Cytochemical and ultrastructural identification of a small type granule in human late eosinophils. Lab Invest 1974;30:557-567. 7. Weller PF, Goetzl EJ, Austen KF: Identification of human eosinophil lysophospholipase as a constituent of Charcot-Leyden crystals. Proc Natl Acad Sci USA 1980;77:7440-7443.Crossref 8. Weller PF, Wasserman SI, Austen KF: Selected enzymes preferentially present in the eosinophil , in Mahmoud AAF, Austen KF (eds): The Eosinophil in Health and Disease . New York, Grune & Stratton Inc, 1980, pp 115-130. 9. Altman LC, Hill JS, Hairfield WM, et al: Effects of corticosteroids on eosinophil chemotaxis and adherence. J Clin Invest 1981;67:28-36.Crossref 10. Koch-Weser J: Beta adrenergic blockade and circulating eosinophils. Arch Intern Med 1968;121:255-258.Crossref 11. Butterworth AE, David JR: Current concepts: Eosinophil function. N Engl J Med 1981;304:154-156.Crossref 12. Ottesen EA, Cohen SG: The eosinophil, eosinophilia, and eosinophil-related disorders , in Middleton E, Reed CE, Ellis EF (eds): Allergy: Principles and Practice . St Louis, CV Mosby Co, 1978, pp 584-632. 13. Samter M, Wasserman SI: Eosinophils , in Samter M (ed): Immunological Diseases . Boston, Little Brown & Co, 1978, pp 230-243. 14. Gleich GJ, Loegering DA, Frigas E, et al: The major basic protein of the eosinophil granule: Physiochemical properties, localization and function , in Mahmoud AAF, Austen KF (eds): The Eosinophil in Health and Disease . New York, Grune & Stratton Inc, 1980, pp 79-97. 15. Gleich GJ, Frigas E, Loegering DA, et al: Cytotoxic properties of the eosinophil major basic protein. J Immunol 1979;123:2925-2927. 16. Filley WV, Kephart GM, Gleich GJ: Localization of the eosinophil granule major basic protein (MBP) in the bronchi of patients with asthma. J Allergy Clin Immunol 1981;67( (suppl) ):54.Crossref 17. Lee TC, Malone B, Wasserman SI, et al: Activities of enzymes that metabolize platelet-activating factor (1-alky-2-acetyl-sn-glycerol-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of calcium ionophore. Biochem Biophys Res Commun 1982;105:1303-1308.Crossref 18. Horn BR, Robin ED, Theodore J, et al: Total eosinophil counts in the management of bronchial asthma. N Engl J Med 1975;292:1152-1155.Crossref 19. Honsinger RW, Silverstein D, Van Arsdel PP: The eosinophil and allergy: Why? J Allergy Clin Immunol 1972;49:142-155.Crossref 20. Schwartz HJ, Lowell FC, Melby JC: Steroid resistance in bronchial asthma. Ann Intern Med 1968;69:493-499.Crossref 21. Crofton JW, Livingston JL, Oswald NC, et al: Pulmonary eosinophilia. Thorax 1952;7:1-35.Crossref 22. Patterson R, Irons JS, Kelly JF, et al: Pulmonary infiltrates with eosinophilia. J Allergy Clin Immunol 1974;53:245-255.Crossref 23. Leitch AG: Pulmonary eosinophilia. Am Thoracic Soc News 1979;7:22-27. 24. Schatz M, Wasserman S, Patterson R: Eosinophils and immunologic lung disease. Med Clin North Am 1981;65:1055-1071. 25. Imbeau SA, Nichols D, Flaherty D, et al: Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 1978;62:243-255.Crossref 26. Rosenberg M, Patterson R, Mintzer R: Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med 1977;86:405-414.Crossref 27. Wang JF, Patterson R, Roberts M, et al: The management of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis 1979;120:87-92. 28. Carrington CB, Addington WW, Goff AM, et al: Chronic eosinophilic pneumonia. N Engl J Med 1969;280:787-798.Crossref 29. Pearson DJ, Rosenow EC III: Chronic eosinophilic pneumonia (Carrington's): A follow-up study. Mayo Clin Proc 1978;53:73-78. 30. Cole P: Drug-induced lung disease. Drugs 1977;13:422-444.Crossref 31. Sovijarvi ARA, Lemola M, Stenius B, et al: Nitrofurantoin-induced acute, subacute, and chronic pulmonary reaction. Scand J Respir Dis 1977;58:41-50. 32. Chusid MJ, Dale DL, West BC, et al: The hypereosinophilic syndrome: Analysis of 14 cases with review of the literature. Medicine 1975;54:1-27.Crossref 33. Parrillo J, Fauci AS, Wolff SM: Therapy of the hypereosinophilic syndrome. Ann Intern Med 1978;89:167-172.Crossref 34. Neva FA, Ottesen FA: Tropical (filarial) eosinophilia. N Engl J Med 1978;298:1129-1131.Crossref 35. Tan JS: Common and uncommon parasitic infections in the United States. Med Clin North Am 1978;62:1059-1081. 36. Phills JA, Harrold AJ, Whiteman GV, et al: Pulmonary infiltrates, asthma, and eosinophilia due to Ascaris worm infestion in man. N Engl J Med 1972;286:965-970.Crossref 37. Drugs for parasitic infections. Med Lett Drugs Ther 1982;24:5-12. 38. Chumbley LC, Harrison EG Jr, DeRemee RA: Allergic granulomatosis and angitis: Report and analysis of 30 cases. Mayo Clin Proc 1977;52:477-484. 39. Cooper BJ, Bacal E, Patterson R: Allergic angiitis and granulomatosis: Prolonged remission induced by combined prednisone-azathioprine therapy. Arch Intern Med 1978;138:367-371.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340210113021
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Abstract

Abstract • Current concepts regarding the morphology, constituents, distribution, and kinetics of the eosinophil allow an expanded understanding of the eosinophil's function in health and disease. In particular, certain eosinophil constituents may have beneficial effects (modulation of mast cell-dependent reactions and helminthotoxic properties), while others may produce detrimental effects (tissue destruction). Eosinophils may be clinically important in obstructive and infiltrative pulmonary diseases. In obstructive disease, a peripheral eosinophilia indicates reversibility, and the magnitude of the peripheral eosinophil count correlates with the severity of the reversible obstruction. Concerning infiltrative pulmonary disease, an updated classification of pulmonary infiltrates with eosinophilia, which is based on recognizable causes and syndromes, is presented, and allergic bronchopulmonary aspergillosis, chronic eosinophilic pneumonia, drug reactions, the hypereosinophilic syndrome, parasitic infestations, and the Churg-Strauss syndrome are specifically considered. (Arch Intern Med 1982;142:1515-1519) References 1. Archer GT, Hirsch JG: Isolation of granules from eosinophil leukocytes and study of their enzyme content. J Exp Med 1963;118:277-285.Crossref 2. Zeiger RS, Yordin DL, Colten HR: Histamine metabolism: II. Cellular and subcellular localization of the catabolic enzymes, histaminase and histamine methyl transferase in human leukocytes. J Allergy Clin Immunol 1976;58:172-179.Crossref 3. Venge P, Roxin LE, Olssom I: Radioimmunoassay of human eosinophil cationic protein. Br J Haematol 1977;37:331-335.Crossref 4. Gleich GJ, Loegering DA, Marin KG, et al: Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. J Clin Invest 1976;57:633-640.Crossref 5. Durack DT, Ackerman SJ, Loegering DA, et al: Purification of human eosinophil-derived neurotoxin. Proc Natl Acad Sci USA 1981;78:5165-5169.Crossref 6. Parmley RT, Spicer SS: Cytochemical and ultrastructural identification of a small type granule in human late eosinophils. Lab Invest 1974;30:557-567. 7. Weller PF, Goetzl EJ, Austen KF: Identification of human eosinophil lysophospholipase as a constituent of Charcot-Leyden crystals. Proc Natl Acad Sci USA 1980;77:7440-7443.Crossref 8. Weller PF, Wasserman SI, Austen KF: Selected enzymes preferentially present in the eosinophil , in Mahmoud AAF, Austen KF (eds): The Eosinophil in Health and Disease . New York, Grune & Stratton Inc, 1980, pp 115-130. 9. Altman LC, Hill JS, Hairfield WM, et al: Effects of corticosteroids on eosinophil chemotaxis and adherence. J Clin Invest 1981;67:28-36.Crossref 10. Koch-Weser J: Beta adrenergic blockade and circulating eosinophils. Arch Intern Med 1968;121:255-258.Crossref 11. Butterworth AE, David JR: Current concepts: Eosinophil function. N Engl J Med 1981;304:154-156.Crossref 12. Ottesen EA, Cohen SG: The eosinophil, eosinophilia, and eosinophil-related disorders , in Middleton E, Reed CE, Ellis EF (eds): Allergy: Principles and Practice . St Louis, CV Mosby Co, 1978, pp 584-632. 13. Samter M, Wasserman SI: Eosinophils , in Samter M (ed): Immunological Diseases . Boston, Little Brown & Co, 1978, pp 230-243. 14. Gleich GJ, Loegering DA, Frigas E, et al: The major basic protein of the eosinophil granule: Physiochemical properties, localization and function , in Mahmoud AAF, Austen KF (eds): The Eosinophil in Health and Disease . New York, Grune & Stratton Inc, 1980, pp 79-97. 15. Gleich GJ, Frigas E, Loegering DA, et al: Cytotoxic properties of the eosinophil major basic protein. J Immunol 1979;123:2925-2927. 16. Filley WV, Kephart GM, Gleich GJ: Localization of the eosinophil granule major basic protein (MBP) in the bronchi of patients with asthma. J Allergy Clin Immunol 1981;67( (suppl) ):54.Crossref 17. Lee TC, Malone B, Wasserman SI, et al: Activities of enzymes that metabolize platelet-activating factor (1-alky-2-acetyl-sn-glycerol-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of calcium ionophore. Biochem Biophys Res Commun 1982;105:1303-1308.Crossref 18. Horn BR, Robin ED, Theodore J, et al: Total eosinophil counts in the management of bronchial asthma. N Engl J Med 1975;292:1152-1155.Crossref 19. Honsinger RW, Silverstein D, Van Arsdel PP: The eosinophil and allergy: Why? J Allergy Clin Immunol 1972;49:142-155.Crossref 20. Schwartz HJ, Lowell FC, Melby JC: Steroid resistance in bronchial asthma. Ann Intern Med 1968;69:493-499.Crossref 21. Crofton JW, Livingston JL, Oswald NC, et al: Pulmonary eosinophilia. Thorax 1952;7:1-35.Crossref 22. Patterson R, Irons JS, Kelly JF, et al: Pulmonary infiltrates with eosinophilia. J Allergy Clin Immunol 1974;53:245-255.Crossref 23. Leitch AG: Pulmonary eosinophilia. Am Thoracic Soc News 1979;7:22-27. 24. Schatz M, Wasserman S, Patterson R: Eosinophils and immunologic lung disease. Med Clin North Am 1981;65:1055-1071. 25. Imbeau SA, Nichols D, Flaherty D, et al: Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 1978;62:243-255.Crossref 26. Rosenberg M, Patterson R, Mintzer R: Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med 1977;86:405-414.Crossref 27. Wang JF, Patterson R, Roberts M, et al: The management of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis 1979;120:87-92. 28. Carrington CB, Addington WW, Goff AM, et al: Chronic eosinophilic pneumonia. N Engl J Med 1969;280:787-798.Crossref 29. Pearson DJ, Rosenow EC III: Chronic eosinophilic pneumonia (Carrington's): A follow-up study. Mayo Clin Proc 1978;53:73-78. 30. Cole P: Drug-induced lung disease. Drugs 1977;13:422-444.Crossref 31. Sovijarvi ARA, Lemola M, Stenius B, et al: Nitrofurantoin-induced acute, subacute, and chronic pulmonary reaction. Scand J Respir Dis 1977;58:41-50. 32. Chusid MJ, Dale DL, West BC, et al: The hypereosinophilic syndrome: Analysis of 14 cases with review of the literature. Medicine 1975;54:1-27.Crossref 33. Parrillo J, Fauci AS, Wolff SM: Therapy of the hypereosinophilic syndrome. Ann Intern Med 1978;89:167-172.Crossref 34. Neva FA, Ottesen FA: Tropical (filarial) eosinophilia. N Engl J Med 1978;298:1129-1131.Crossref 35. Tan JS: Common and uncommon parasitic infections in the United States. Med Clin North Am 1978;62:1059-1081. 36. Phills JA, Harrold AJ, Whiteman GV, et al: Pulmonary infiltrates, asthma, and eosinophilia due to Ascaris worm infestion in man. N Engl J Med 1972;286:965-970.Crossref 37. Drugs for parasitic infections. Med Lett Drugs Ther 1982;24:5-12. 38. Chumbley LC, Harrison EG Jr, DeRemee RA: Allergic granulomatosis and angitis: Report and analysis of 30 cases. Mayo Clin Proc 1977;52:477-484. 39. Cooper BJ, Bacal E, Patterson R: Allergic angiitis and granulomatosis: Prolonged remission induced by combined prednisone-azathioprine therapy. Arch Intern Med 1978;138:367-371.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1982

References