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The Efficacy of Steroids in the Treatment of Idiopathic Sudden Hearing Loss: A Double-blind Clinical Study

The Efficacy of Steroids in the Treatment of Idiopathic Sudden Hearing Loss: A Double-blind... Abstract • Double-blind studies were conducted for the treatment of idiopathic sudden hearing loss (ISHL) with oral steroids. The condition was defined as not less than a 30-dB loss over three contiguous frequencies in three days or less. Follow-up audiograms were obtained four weeks and three months later. Specific audiologic guidelines for the assessment of hearing recovery were used to ensure objectivity. Steroids had a statistically significant effect on the recovery of hearing in patients with moderate hearing losses. The nature of the hearing loss and its susceptibility to improvement with steroid therapy lend support to the hypothesis that viral cochlitis is the primary cause of ISHL. (Arch Otolaryngol 106:772-776, 1980) References 1. Siegel LG: The treatment of idiopathic sudden sensorineural hearing loss . Otolaryngol Clin North Am 8:467-473, 1975. 2. Shaia FT, Sheey JL: Sudden sensorineural hearing impairment: A report of 1,220 cases . Laryngoscope 86:389-398, 1976.Crossref 3. Shae JJ, Emmett JR, Harell M: Treatment of sudden hearing loss with diatrizoate meglumine (Hypaque) . Laryngoscope 87:1809-1814, 1977. 4. Byl FM: Seventy-six cases of presumed sudden hearing loss occurring in 1973: Prognosis and incidence . Laryngoscope 87:817-824, 1977.Crossref 5. Schuknecht HF, Kimura RS, Naufal PM: The pathology of sudden deafness . Acta Otolaryngol 76:75-97, 1973.Crossref 6. Sando I, Harada T, Loehr A, et al: Sudden deafness: Histopathologic correlation in temporal bone . Ann Otolaryngol 86:269-279, 1977. 7. Gussen R: Sudden deafness of vascular origin: A human temporal bone study . Ann Otolaryngol 85:94-100, 1976. 8. Simmons FB: Theory of membrane breaks in sudden hearing loss . Arch Otolaryngol 88:67-74, 1968.Crossref 9. Harner SG, Heeny BA, Newell RC: Herpes zoster oticus . Arch Otolaryngol 92:632-635, 1970.Crossref 10. Byl FM, Adour K: Auditory symptoms associated with herpes zoster or idiopathic facial paralysis . Laryngoscope 87:372-379, 1977.Crossref 11. Bishop YMM, Fienberg SE, Holland PW: Discrete Multivariate Analysis . Cambridge, Mass, Massachusetts Institute of Technology Press, 1975. 12. Mattox DE, Simmons FB: Natual history of sudden sensorineural hearing loss . Ann Otol Rhinol Laryngol 86:463-480, 1977. 13. Simmons FB: The double-membrane breaks syndrome in sudden hearing loss . Laryngoscope 89:59-66, 1979.Crossref 14. Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Publishing Co Inc, 1970, p 164. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

The Efficacy of Steroids in the Treatment of Idiopathic Sudden Hearing Loss: A Double-blind Clinical Study

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1980.00790360050013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Double-blind studies were conducted for the treatment of idiopathic sudden hearing loss (ISHL) with oral steroids. The condition was defined as not less than a 30-dB loss over three contiguous frequencies in three days or less. Follow-up audiograms were obtained four weeks and three months later. Specific audiologic guidelines for the assessment of hearing recovery were used to ensure objectivity. Steroids had a statistically significant effect on the recovery of hearing in patients with moderate hearing losses. The nature of the hearing loss and its susceptibility to improvement with steroid therapy lend support to the hypothesis that viral cochlitis is the primary cause of ISHL. (Arch Otolaryngol 106:772-776, 1980) References 1. Siegel LG: The treatment of idiopathic sudden sensorineural hearing loss . Otolaryngol Clin North Am 8:467-473, 1975. 2. Shaia FT, Sheey JL: Sudden sensorineural hearing impairment: A report of 1,220 cases . Laryngoscope 86:389-398, 1976.Crossref 3. Shae JJ, Emmett JR, Harell M: Treatment of sudden hearing loss with diatrizoate meglumine (Hypaque) . Laryngoscope 87:1809-1814, 1977. 4. Byl FM: Seventy-six cases of presumed sudden hearing loss occurring in 1973: Prognosis and incidence . Laryngoscope 87:817-824, 1977.Crossref 5. Schuknecht HF, Kimura RS, Naufal PM: The pathology of sudden deafness . Acta Otolaryngol 76:75-97, 1973.Crossref 6. Sando I, Harada T, Loehr A, et al: Sudden deafness: Histopathologic correlation in temporal bone . Ann Otolaryngol 86:269-279, 1977. 7. Gussen R: Sudden deafness of vascular origin: A human temporal bone study . Ann Otolaryngol 85:94-100, 1976. 8. Simmons FB: Theory of membrane breaks in sudden hearing loss . Arch Otolaryngol 88:67-74, 1968.Crossref 9. Harner SG, Heeny BA, Newell RC: Herpes zoster oticus . Arch Otolaryngol 92:632-635, 1970.Crossref 10. Byl FM, Adour K: Auditory symptoms associated with herpes zoster or idiopathic facial paralysis . Laryngoscope 87:372-379, 1977.Crossref 11. Bishop YMM, Fienberg SE, Holland PW: Discrete Multivariate Analysis . Cambridge, Mass, Massachusetts Institute of Technology Press, 1975. 12. Mattox DE, Simmons FB: Natual history of sudden sensorineural hearing loss . Ann Otol Rhinol Laryngol 86:463-480, 1977. 13. Simmons FB: The double-membrane breaks syndrome in sudden hearing loss . Laryngoscope 89:59-66, 1979.Crossref 14. Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Publishing Co Inc, 1970, p 164.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Dec 1, 1980

References