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References (9)
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I. Frantz, M. Mobberley, G. Schroepfer (1960)
Effects of MER-29 on the intermediary metabolism of cholesterol.Progress in cardiovascular diseases, 2
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W. Hollander, A. Chobanian (1959)
The effects of an inhibitor of cholesterol biosynthesis triparanol (MER-29), in subjects with and without coronary artery disease.BMQ; the Boston medical quarterly, 10 2
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Inhibition of cholesterol synthesis with the use of Mer-29.Archives of internal medicine, 104
- Publisher
- American Medical Association
- Copyright
- Copyright © 1960 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.1960.03030010007002
- Publisher site
- See Article on Publisher Site
Abstract
Triparanol, an inhibitor of cholesterol biosynthesis, significantly reduced the serum cholesterol in 71 of 89 subjects with and without hypercholesterolemia. The compound in a maximally effective dose of 250 mg. per day was well tolerated and caused no serious side effects. The decrease in serum cholesterol (Abell) averaged 45 mg. % and ranged from 20 to 110 mg. %. The ratio of serum cholesterol to serum phospholipid also was favorably influenced by therapy. Triparanol, as indicated by radioisotopic tracer studies, also appeared to reduce the total sterol and cholesterol content of the body by decreasing the formation of cholesterol the body. The compound appeared to have an anti-anginal effect in 12 of 28 subjects and to improve the electrocardiographic responses to exercise in 3 of 11 subjects with angina pectoris. These effects were associated with a fall in serum cholesterol.
Journal
JAMA – American Medical Association
Published: Sep 3, 1960