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The Effect of Thio-TEPA on Wound Healing

The Effect of Thio-TEPA on Wound Healing Abstract It has been shown by several investigators that tumor cell emboli are present in the blood stream of patients with carcinoma. Cancer cells were demonstrated in the venous blood draining organs involved by cancer by McGrew et al.1 and by Fisher and Turnbull.2 Engel3 and Moore et al.4 have also demonstrated the presence of tumor cell emboli in the peripheral blood of patients with carcinoma. The administration of cancericidal chemotherapeutic agents at the time of surgical removal of carcinoma to destroy any tumor cells existing as emboli was suggested by Cruz, McDonald, and Cole.5 Mechlorethamine (nitrogen mustard) and Thio-TEPA (triethylenethiophosphoramide) have been shown by Cole and his group6 to be markedly effective in reducing the incidence of tumor cell "take" when given to animals having Walker 256 carcinosarcoma cell suspensions injected into the portal vein. The clinical use of cancericidal agents at the time References 1. McGrew, E. A.; Laws, J. F., and Cole, W. H.: Free Malignant Cells in Relation to Recurrence of Carcinoma of the Colon , J.A.M.A. 154:1251, 1954.Crossref 2. Fisher, D. R., and Turnbull, R. B., Jr.: The Cytologic Demonstration and Significance of Tumor Cells in the Mesenteric Venous Blood in Patients with Colorectal Carcinoma , Surg., Gynec. & Obst. 100:102, 1955. 3. Engel, H. C.: Cancer Cells in the Circulating Blood , Acta chir. scandinav. Supp. 201, 1955. 4. Moore, G. E.; Sandberg, A., and Schubarg, J. R.: Clinical and Experimental Observations of the Occurrence and Fate of Tumor Cells in the Blood Stream , Ann. Surg. 146:580, 1957. 5. Cruz, E. P.; McDonald, G. O., and Cole, W. H.: Prophylactic Treatment of Cancer , Surgery 40:291, 1956. 6. McDonald, G. O.; Livingston, C.; Boyles, C. F., and Cole, W. H.: The Prophylactic Treatment of Malignant Disease with Nitrogen Mustard and Triethylenethiophosphoramdide (Thio-TEPA) , Ann. Surg. 145:5, 1957. 7. Morales, F.; Bell, M.; McDonald, G. O., and Cole, W. H.: The Prophylactic Treatment of Cancer at the Time of Operation , Ann. Surg. 146:588, 1957. 8. Moore, G. E., and Kondo, T.: Study of Adjuvant Cancer Chemotherapy by Model Experiments , Surgery 44:199, 1958. 9. Krementz, E. T.; Giddens, W. R., and Chapman, W. L.: Effects of Triethylenemelamine on Wound Healing , S. Forum 8:83, 1957. 10. Farhat, S. M.; Amer, N. S.; Weeks, D. S., and Musselman, M. M.: Effect of Mechlorethamine Hydrochloride (Nitrogen Mustard) on Healing of Abdominal Wounds , A.M.A. Arch. Surg. 76:749, 1958. 11. Conn, J. H.; Leb, S. M., and Hardy, J. D.: Effect of Nitrogen Mustard and Thio-TEPA on Wound Healing , S. Forum 8:80, 1957. 12. Fast, J.; Nelson, C., and Dennis, C.: Rate of Gain in Strength in Sutured Abdominal Wall Wounds , Surg., Gynec. & Obst. 84:685, 1947. 13. Nelson, C. A., and Dennis, C.: Wound Healing: Technical Factors in the Gain of Strength in Sutured Abdominal Wall Wounds in Rabbits , Surg., Gynec. & Obst. 93:461, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

The Effect of Thio-TEPA on Wound Healing

A.M.A. Archives Surgery , Volume 79 (5) – Nov 1, 1959

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1959.04320110114018
Publisher site
See Article on Publisher Site

Abstract

Abstract It has been shown by several investigators that tumor cell emboli are present in the blood stream of patients with carcinoma. Cancer cells were demonstrated in the venous blood draining organs involved by cancer by McGrew et al.1 and by Fisher and Turnbull.2 Engel3 and Moore et al.4 have also demonstrated the presence of tumor cell emboli in the peripheral blood of patients with carcinoma. The administration of cancericidal chemotherapeutic agents at the time of surgical removal of carcinoma to destroy any tumor cells existing as emboli was suggested by Cruz, McDonald, and Cole.5 Mechlorethamine (nitrogen mustard) and Thio-TEPA (triethylenethiophosphoramide) have been shown by Cole and his group6 to be markedly effective in reducing the incidence of tumor cell "take" when given to animals having Walker 256 carcinosarcoma cell suspensions injected into the portal vein. The clinical use of cancericidal agents at the time References 1. McGrew, E. A.; Laws, J. F., and Cole, W. H.: Free Malignant Cells in Relation to Recurrence of Carcinoma of the Colon , J.A.M.A. 154:1251, 1954.Crossref 2. Fisher, D. R., and Turnbull, R. B., Jr.: The Cytologic Demonstration and Significance of Tumor Cells in the Mesenteric Venous Blood in Patients with Colorectal Carcinoma , Surg., Gynec. & Obst. 100:102, 1955. 3. Engel, H. C.: Cancer Cells in the Circulating Blood , Acta chir. scandinav. Supp. 201, 1955. 4. Moore, G. E.; Sandberg, A., and Schubarg, J. R.: Clinical and Experimental Observations of the Occurrence and Fate of Tumor Cells in the Blood Stream , Ann. Surg. 146:580, 1957. 5. Cruz, E. P.; McDonald, G. O., and Cole, W. H.: Prophylactic Treatment of Cancer , Surgery 40:291, 1956. 6. McDonald, G. O.; Livingston, C.; Boyles, C. F., and Cole, W. H.: The Prophylactic Treatment of Malignant Disease with Nitrogen Mustard and Triethylenethiophosphoramdide (Thio-TEPA) , Ann. Surg. 145:5, 1957. 7. Morales, F.; Bell, M.; McDonald, G. O., and Cole, W. H.: The Prophylactic Treatment of Cancer at the Time of Operation , Ann. Surg. 146:588, 1957. 8. Moore, G. E., and Kondo, T.: Study of Adjuvant Cancer Chemotherapy by Model Experiments , Surgery 44:199, 1958. 9. Krementz, E. T.; Giddens, W. R., and Chapman, W. L.: Effects of Triethylenemelamine on Wound Healing , S. Forum 8:83, 1957. 10. Farhat, S. M.; Amer, N. S.; Weeks, D. S., and Musselman, M. M.: Effect of Mechlorethamine Hydrochloride (Nitrogen Mustard) on Healing of Abdominal Wounds , A.M.A. Arch. Surg. 76:749, 1958. 11. Conn, J. H.; Leb, S. M., and Hardy, J. D.: Effect of Nitrogen Mustard and Thio-TEPA on Wound Healing , S. Forum 8:80, 1957. 12. Fast, J.; Nelson, C., and Dennis, C.: Rate of Gain in Strength in Sutured Abdominal Wall Wounds , Surg., Gynec. & Obst. 84:685, 1947. 13. Nelson, C. A., and Dennis, C.: Wound Healing: Technical Factors in the Gain of Strength in Sutured Abdominal Wall Wounds in Rabbits , Surg., Gynec. & Obst. 93:461, 1951.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Nov 1, 1959

References