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THE EFFECT OF TEMPORARY OCCLUSION OF RENAL CIRCULATION ON RENAL FUNCTION

THE EFFECT OF TEMPORARY OCCLUSION OF RENAL CIRCULATION ON RENAL FUNCTION Abstract Of great importance in relation to the surgery of the kidney is the is the question concerning the length of time that the renal vessels may be clamped without permanent injury to renal function or renal tissue. The question is dealt with here experimentally. The renal vessels in rabbits and dogs have been clamped for varying periods of time, and subsequently renal function has been tested by the excretion of phenolsulphonephthalein, lactose, potassium iodid, salt and water. The presence or absence of albumin and casts in the urine has been observed. The results of such functional studies have been controlled by histological examination of the kidneys. The effect of obstruction to the renal circulation on the urinary picture and the histology of the kidney has already been investigated. Robinson1 showed that tying of the renal vein resulted in the appearance of albumin, blood, or both, in the References 1. Robinson: Med. Chir. Tr. , 1843, xxvi, 51. 2. Paneth: Pflüger's Arch. , 1886, xxxix, 515.Crossref 3. Munk: Berl. klin. Wchnschr. , 1864, i, 333. 4. De Souza: Jour. Physiol. , 1900, xxvi, 139. 5. Ludwig Physiologie , 1856, ii, 416. 6. Heidenhain: Hermann's Handb. d. Physiol. , 1883, v, Teil 1, 321. 7. Litten: Ztschr. f. klin. Med. , 1880, p. 131. 8. Chirié and Mayer: Compt. rend. Soc. de biol. , 1907, i, 598. 9. Carrel: Compt. rend. d. Soc. de biol. , 1909, i, 527. 10. Eisendrath and Strauss: Jour. Am. Med. Assn. , 1910, lv, 2286Crossref 11. Guthrie: The Archives Int. Med. , 1910, v, 232.Crossref 12. Rowntree and Geraghty: Jour. Phar. and Exper. Therap. , 1910, i, 579. 13. Rowntree and Geraghty: The Archives Int. Med. , 1912, ix, 284.Crossref 14. Schlayer: Deutsch. Arch. f. klin. Med. , 1911, cii, 311 15. Schlayer and Takayasu: Deutsch. Arch. f. klin. Med. , 1891, xcviii, 17 16. 1910, ci, 333. 17. For a review of the literature on this test and the others described below, see our previous paper. We have shown in a previous publication, however, that lactose is not excreted solely by the glomeruli. 18. Sandow's method consists in adding 1 c.c. of 2 per cent. sodium nitrite solution and 1 c.c. of 10 per cent. H2SO4 to from 10 to 30 c.c. of urine, followed by the addition of a small amount of chloroform. This is shaken together and allowed to separate into layers, the presence of the iodid being indicated by a purplish red or violet color in the chloroform. 19. Sahli: Lehrbuch der klinischen untersuchungs, Methoden , Franz Deuticke, Leipzig and Wien, 1899, p. 421. 20. In addition seven rabbits were used, one with circulation clamped for ten minutes, three for thirty minutes, and two for forty minutes. All died within sixteen hours of operation. Realizing the individual variation in susceptibility and vitality of rabbits, it seemed fair to exclude these animals from their appropriate tables, especially as all had been deeply anesthetized, all but one had made poor ether recoveries, and one rabbit at operation had suffered from a severe hemorrhage due to trauma of the liver. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE EFFECT OF TEMPORARY OCCLUSION OF RENAL CIRCULATION ON RENAL FUNCTION

FITZ, R.; ROWNTREE, L. G.
Archives of Internal Medicine , Volume XII (1) – Jul 1, 1913
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Publisher
American Medical Association
Copyright
Copyright © 1913 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1913.00070010027002
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Abstract

Abstract Of great importance in relation to the surgery of the kidney is the is the question concerning the length of time that the renal vessels may be clamped without permanent injury to renal function or renal tissue. The question is dealt with here experimentally. The renal vessels in rabbits and dogs have been clamped for varying periods of time, and subsequently renal function has been tested by the excretion of phenolsulphonephthalein, lactose, potassium iodid, salt and water. The presence or absence of albumin and casts in the urine has been observed. The results of such functional studies have been controlled by histological examination of the kidneys. The effect of obstruction to the renal circulation on the urinary picture and the histology of the kidney has already been investigated. Robinson1 showed that tying of the renal vein resulted in the appearance of albumin, blood, or both, in the References 1. Robinson: Med. Chir. Tr. , 1843, xxvi, 51. 2. Paneth: Pflüger's Arch. , 1886, xxxix, 515.Crossref 3. Munk: Berl. klin. Wchnschr. , 1864, i, 333. 4. De Souza: Jour. Physiol. , 1900, xxvi, 139. 5. Ludwig Physiologie , 1856, ii, 416. 6. Heidenhain: Hermann's Handb. d. Physiol. , 1883, v, Teil 1, 321. 7. Litten: Ztschr. f. klin. Med. , 1880, p. 131. 8. Chirié and Mayer: Compt. rend. Soc. de biol. , 1907, i, 598. 9. Carrel: Compt. rend. d. Soc. de biol. , 1909, i, 527. 10. Eisendrath and Strauss: Jour. Am. Med. Assn. , 1910, lv, 2286Crossref 11. Guthrie: The Archives Int. Med. , 1910, v, 232.Crossref 12. Rowntree and Geraghty: Jour. Phar. and Exper. Therap. , 1910, i, 579. 13. Rowntree and Geraghty: The Archives Int. Med. , 1912, ix, 284.Crossref 14. Schlayer: Deutsch. Arch. f. klin. Med. , 1911, cii, 311 15. Schlayer and Takayasu: Deutsch. Arch. f. klin. Med. , 1891, xcviii, 17 16. 1910, ci, 333. 17. For a review of the literature on this test and the others described below, see our previous paper. We have shown in a previous publication, however, that lactose is not excreted solely by the glomeruli. 18. Sandow's method consists in adding 1 c.c. of 2 per cent. sodium nitrite solution and 1 c.c. of 10 per cent. H2SO4 to from 10 to 30 c.c. of urine, followed by the addition of a small amount of chloroform. This is shaken together and allowed to separate into layers, the presence of the iodid being indicated by a purplish red or violet color in the chloroform. 19. Sahli: Lehrbuch der klinischen untersuchungs, Methoden , Franz Deuticke, Leipzig and Wien, 1899, p. 421. 20. In addition seven rabbits were used, one with circulation clamped for ten minutes, three for thirty minutes, and two for forty minutes. All died within sixteen hours of operation. Realizing the individual variation in susceptibility and vitality of rabbits, it seemed fair to exclude these animals from their appropriate tables, especially as all had been deeply anesthetized, all but one had made poor ether recoveries, and one rabbit at operation had suffered from a severe hemorrhage due to trauma of the liver.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jul 1, 1913

References

  • Hermann's Handb. d. Physiol.
    Heidenhain
  • Lehrbuch der klinischen untersuchungs, Methoden
    Sahli