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The Effect of Systemic Chloroquine Therapy on Actinic Keratoses: Report of Two Cases in Albino Negroes

The Effect of Systemic Chloroquine Therapy on Actinic Keratoses: Report of Two Cases in Albino... Abstract One of the problems in persons with "chataigne," or farmer's, type of skin is the continuous development of senile keratoses and the frequent malignant transformation of these keratoses following chronic exposure to sunlight. Recent experience with two patients suggests that chloroquine may be a partial inhibitor of this process. The usefulness of antimalarial drugs in the treatment of lupus erythematosus has been known for several years now.1 More recently, these drugs have been found to be effective therapeutic agents for polymorphic light-sensitivity eruptions.2,3 In 1957, two albino Negro women reported to the Dermatology Clinic at Jefferson Davis Hospital for treatment of discoid lupus erythematosus and a chlorpromazine photosensitivity, respectively. Both had advanced actinic degeneration and numerous senile keratoses in exposed areas. The patients were followed at regular intervals for the keratotic lesions, as well as for their primary condition. Report of Cases References 1. Page. F.: Treatment of Lupus Erythematosus with Mepacrine , Lancet 2:755-758 ( (Oct. 27) ) 1951.Crossref 2. Knox, J. M.; Lamb, J. H.; Shelmire, B., and Morgan, R. J.: Light Sensitive Eruptions Treated with Atabrine and Chloroquine , J. Invest. Dermat. 22:11-16, 1954.Crossref 3. Cahn, M. M.; Levy, E. J., and Shaffer, B.: The Use of Chloroquine Diphosphate (Aralen) and Quinacrine (Atabrine) Hydrochloride in the Prevention of Polymorphous Light Eruptions , J. Invest. Dermat. 22:93-96, 1954. 4. Griffin, A. C.; Hakim, R. E., and Knox, J. M.: The Effect of Chloroquine on the Erythematous and Carcinogenic Response to Ultraviolet Light , presented before the Dermatology Section at the meeting of the American Medical Association, Atlantic City, N. J., June 1959 . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Effect of Systemic Chloroquine Therapy on Actinic Keratoses: Report of Two Cases in Albino Negroes

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560210089019
Publisher site
See Article on Publisher Site

Abstract

Abstract One of the problems in persons with "chataigne," or farmer's, type of skin is the continuous development of senile keratoses and the frequent malignant transformation of these keratoses following chronic exposure to sunlight. Recent experience with two patients suggests that chloroquine may be a partial inhibitor of this process. The usefulness of antimalarial drugs in the treatment of lupus erythematosus has been known for several years now.1 More recently, these drugs have been found to be effective therapeutic agents for polymorphic light-sensitivity eruptions.2,3 In 1957, two albino Negro women reported to the Dermatology Clinic at Jefferson Davis Hospital for treatment of discoid lupus erythematosus and a chlorpromazine photosensitivity, respectively. Both had advanced actinic degeneration and numerous senile keratoses in exposed areas. The patients were followed at regular intervals for the keratotic lesions, as well as for their primary condition. Report of Cases References 1. Page. F.: Treatment of Lupus Erythematosus with Mepacrine , Lancet 2:755-758 ( (Oct. 27) ) 1951.Crossref 2. Knox, J. M.; Lamb, J. H.; Shelmire, B., and Morgan, R. J.: Light Sensitive Eruptions Treated with Atabrine and Chloroquine , J. Invest. Dermat. 22:11-16, 1954.Crossref 3. Cahn, M. M.; Levy, E. J., and Shaffer, B.: The Use of Chloroquine Diphosphate (Aralen) and Quinacrine (Atabrine) Hydrochloride in the Prevention of Polymorphous Light Eruptions , J. Invest. Dermat. 22:93-96, 1954. 4. Griffin, A. C.; Hakim, R. E., and Knox, J. M.: The Effect of Chloroquine on the Erythematous and Carcinogenic Response to Ultraviolet Light , presented before the Dermatology Section at the meeting of the American Medical Association, Atlantic City, N. J., June 1959 .

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1959

References