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The Effect of Oral Sodium Phosphate Drug Products on Renal Function in Adults Undergoing Bowel Endoscopy

The Effect of Oral Sodium Phosphate Drug Products on Renal Function in Adults Undergoing Bowel... ORIGINAL INVESTIGATION The Effect of Oral Sodium Phosphate Drug Products on Renal Function in Adults Undergoing Bowel Endoscopy Anand Khurana, MD; Luciana McLean, MD; Sheree Atkinson, BS, CCRP; Charles J. Foulks, MD Background: Oral sodium phosphate solution (OSPS) line glomerular filtration rate (GFR) in the study group preparations are preferred cleansing agents for colonos- was 79 mL/min/1.73 m , which declined to 73 mL/min/ copy because of ease of use and excellent preparation qual- 1.73 m at 6 months after exposure to OSPS prepara- ity. Besides causing acute renal failure in some patients, tion. This finding was significantly different from the con- the high phosphorus content can potentially cause chronic trol group, in whom the baseline GFR was 76 mL/min/ kidney damage to patients undergoing colonoscopy. 1.73 m and remained stable at 6 months. Linear regression analysis showed that use of angiotensin- Methods: We carried out a retrospective study on pa- converting enzyme inhibitors and/or angiotensin recep- tients with creatinine levels in the normal range who had tor blockers and the presence of diabetes were signifi- undergone colonoscopy or flexible sigmoidoscopy using cant determinants of the fall in GFR after use of OSPS OSPS preparation from January 1998 to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

The Effect of Oral Sodium Phosphate Drug Products on Renal Function in Adults Undergoing Bowel Endoscopy

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Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinte.168.6.593
pmid
18362251
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION The Effect of Oral Sodium Phosphate Drug Products on Renal Function in Adults Undergoing Bowel Endoscopy Anand Khurana, MD; Luciana McLean, MD; Sheree Atkinson, BS, CCRP; Charles J. Foulks, MD Background: Oral sodium phosphate solution (OSPS) line glomerular filtration rate (GFR) in the study group preparations are preferred cleansing agents for colonos- was 79 mL/min/1.73 m , which declined to 73 mL/min/ copy because of ease of use and excellent preparation qual- 1.73 m at 6 months after exposure to OSPS prepara- ity. Besides causing acute renal failure in some patients, tion. This finding was significantly different from the con- the high phosphorus content can potentially cause chronic trol group, in whom the baseline GFR was 76 mL/min/ kidney damage to patients undergoing colonoscopy. 1.73 m and remained stable at 6 months. Linear regression analysis showed that use of angiotensin- Methods: We carried out a retrospective study on pa- converting enzyme inhibitors and/or angiotensin recep- tients with creatinine levels in the normal range who had tor blockers and the presence of diabetes were signifi- undergone colonoscopy or flexible sigmoidoscopy using cant determinants of the fall in GFR after use of OSPS OSPS preparation from January 1998 to

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Mar 24, 2008

References