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The Effect of Mephenesin on Muscle Tension: An Experimental Study

The Effect of Mephenesin on Muscle Tension: An Experimental Study Abstract Since mephenesin was introduced as a muscle relaxant by Berger and Bradley,1 in 1946, there have been many clinical reports concerning its use in spastic and hyperkinetic states.* No uniformity was noted in regard to its efficacy in the treatment of these disorders. More recently, the use of mephenesin was extended to the treatment of anxiety states.† Once again, ensuing clinical reports concerning its efficiency in alleviating anxiety were of varying degrees of enthusiasm.‡ The increase of muscle tension in anxiety states is well known. To our knowledge, there have been no quantitative studies of muscle tension responses after the administration of mephenesin in humans. We therefore felt it would be useful to study quantitatively muscle tension in anxious people and to report whether or not mephenesin could be shown to reduce muscle tension, in a predictable fashion. Anxiety is a subjective state associated with physiologic changes, which may References 1. References 2, 17, 20, and 21. 2. References 2, 5, 7, 8, 19, 22, and 23. 3. References 2, 5, 7, 8, 19, 22, 23, and 25. 4. References 6, 9, 10, 12, 15, and 18. 5. We used a projector with an electronic timing device to control the duration of exposure of the stimulus words. This was devised and built in our department. 6. References 3 and 16. 7. Berger, F. M., and Bradley, W.: The Pharmacological Properties of α:β-Dihydroxy-γ-(2Methylphenoxy)-Propane (Myanesin) , Brit. J. Pharmacol. 1:265, 1946. 8. Berger, F. M., and Schwartz, R. P.: Oral "Myanesin" in Treatment of Spastic and Hyperkinetic Disorders , J. A. M. A. 137:772, 1948.Crossref 9. Bruner, J. S., and Postman, L.: Emotional Selectivity in Perception and Reaction , J. Personality 16:69, 1947.Crossref 10. Davis, J. M.: Manual of Surface Electromyography , McGill University, Montreal, Canada, privately published. 11. Dixon, H. H.; Dickel, H. A.; Coen, R. A., and Haugen, G.: Clinical Observations on Tolserol in Handling Anxiety Tension States , Am. J. M. Sc. 220:23, 1950.Crossref 12. Gottschalk, L. A.; Serota, H. M., and Shapiro, L. B.: Psychological Conflict and Neuromuscular Tension: Preliminary Report and Method, as Applied to Rheumatoid Arthritis , Psychosom. Med. 12:315, 1950.Crossref 13. Hecker, A. O.; Mercer, M., and Griffin, N. A., Jr.: Further Clinical Investigation of Tolserol (Myanesin) , Dis. Nerv. System 12:99, 1951. 14. Herman, M., and Effron, A. S.: Tolserol in Treatment of Postalcoholic State , Quart. J. Stud. Alcohol 12:261, 1951. 15. Hoefer, P. F.: Innervation and "Tonus" of Striated Muscle in Man , Arch. Neurol. & Psychiat. 46:947, 1941. 16. Jacobson, E.: Innervation and "Tonus" of Striated Muscle in Man , J. Nerv. & Ment. Dis. 97: 197, 1943. 17. Lazarus, R. S., and McCleary, R. A.: Autonomic Discrimination Without Awareness: A Study of Subconception , Psychiat. Rev. 58:113, 1951. 18. Malmo, R., and Shagass, C.: Physiologic Studies of Reaction to Stress in Anxiety and Early Schizophrenia , Psychosom. Med. 11:9, 1949. 19. Malmo, R., and Shagass, C.: Physiologic Study of Symptom Mechanisms in Psychiatric Patients Under Stress , Psychosom. Med. 11:25, 1949. 20. Malmo, R.; Shagass, C., and Davis, F. R.: Symptom Specificity and Bodily Reactions During Psychiatric Interview , Psychosom. Med. 12:362, 1950. 21. Malmo, R.; Shagass, C., and Davis, J. F.: Electromyographic Studies of Muscular Tension in Psychiatric Patients Under Stress , J. Clin. & Exper. Psychopath. 12:45, 1951. 22. McGinnies, E.: Emotionality and Perceptional Defense , Psychiat. Rev. 56:244, 1949. 23. Mead, S.; Mueller, E. E., and Harell, A.: Use of Intravenous Mephenesin (Tolserol) in Physical Medicine: Clinical and Laboratory Study , Brit. J. Phys. Med. 14:223, 1951. 24. Ruesch, J., and Finesinger, J. E.: Muscular Tension in Psychiatric Patients , Psychosom. Med. 5:132, 1943. 25. Schlan, L. S., and Unna, K. R.: Some Effects of Myanesin in Psychiatric Patients , J. A. M. A. 140:672, 1949. 26. Schlesinger, E. B.: Clinical Applications of Myanesin , Tr. New York Acad. Sc. 11:5, 1948. 27. Schlesinger, E. B.; Drew, L. A., and Wood, B.: Clinical Studies in Use of Myanesin , Am. J. Med. 4:365, 1948. 28. Spreng, R. W. E.: Tolserol in Acute Alcoholism , J. Nerv. & Ment. Dis. 118:545, 1953. 29. Stephen, C. R., and Chandy, J.: Clinical and Experimental Studies with Myanesin (Preliminary Report) , Canad. M. A. J. 57:463, 1947. 30. Thorndike, E. L., and Frage, J.: The Teachers' Word Book of 3,000 Words , New York, Columbia University Press, 1944. 31. Wolf, S., and Pinsky, R. H.: Effects of Placebo Administration and Occurrence of Toxic Reactions , J. A. M. A. 155:339, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

The Effect of Mephenesin on Muscle Tension: An Experimental Study

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330180008002
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Abstract

Abstract Since mephenesin was introduced as a muscle relaxant by Berger and Bradley,1 in 1946, there have been many clinical reports concerning its use in spastic and hyperkinetic states.* No uniformity was noted in regard to its efficacy in the treatment of these disorders. More recently, the use of mephenesin was extended to the treatment of anxiety states.† Once again, ensuing clinical reports concerning its efficiency in alleviating anxiety were of varying degrees of enthusiasm.‡ The increase of muscle tension in anxiety states is well known. To our knowledge, there have been no quantitative studies of muscle tension responses after the administration of mephenesin in humans. We therefore felt it would be useful to study quantitatively muscle tension in anxious people and to report whether or not mephenesin could be shown to reduce muscle tension, in a predictable fashion. Anxiety is a subjective state associated with physiologic changes, which may References 1. References 2, 17, 20, and 21. 2. References 2, 5, 7, 8, 19, 22, and 23. 3. References 2, 5, 7, 8, 19, 22, 23, and 25. 4. References 6, 9, 10, 12, 15, and 18. 5. We used a projector with an electronic timing device to control the duration of exposure of the stimulus words. This was devised and built in our department. 6. References 3 and 16. 7. Berger, F. M., and Bradley, W.: The Pharmacological Properties of α:β-Dihydroxy-γ-(2Methylphenoxy)-Propane (Myanesin) , Brit. J. Pharmacol. 1:265, 1946. 8. Berger, F. M., and Schwartz, R. P.: Oral "Myanesin" in Treatment of Spastic and Hyperkinetic Disorders , J. A. M. A. 137:772, 1948.Crossref 9. Bruner, J. S., and Postman, L.: Emotional Selectivity in Perception and Reaction , J. Personality 16:69, 1947.Crossref 10. Davis, J. M.: Manual of Surface Electromyography , McGill University, Montreal, Canada, privately published. 11. Dixon, H. H.; Dickel, H. A.; Coen, R. A., and Haugen, G.: Clinical Observations on Tolserol in Handling Anxiety Tension States , Am. J. M. Sc. 220:23, 1950.Crossref 12. Gottschalk, L. A.; Serota, H. M., and Shapiro, L. B.: Psychological Conflict and Neuromuscular Tension: Preliminary Report and Method, as Applied to Rheumatoid Arthritis , Psychosom. Med. 12:315, 1950.Crossref 13. Hecker, A. O.; Mercer, M., and Griffin, N. A., Jr.: Further Clinical Investigation of Tolserol (Myanesin) , Dis. Nerv. System 12:99, 1951. 14. Herman, M., and Effron, A. S.: Tolserol in Treatment of Postalcoholic State , Quart. J. Stud. Alcohol 12:261, 1951. 15. Hoefer, P. F.: Innervation and "Tonus" of Striated Muscle in Man , Arch. Neurol. & Psychiat. 46:947, 1941. 16. Jacobson, E.: Innervation and "Tonus" of Striated Muscle in Man , J. Nerv. & Ment. Dis. 97: 197, 1943. 17. Lazarus, R. S., and McCleary, R. A.: Autonomic Discrimination Without Awareness: A Study of Subconception , Psychiat. Rev. 58:113, 1951. 18. Malmo, R., and Shagass, C.: Physiologic Studies of Reaction to Stress in Anxiety and Early Schizophrenia , Psychosom. Med. 11:9, 1949. 19. Malmo, R., and Shagass, C.: Physiologic Study of Symptom Mechanisms in Psychiatric Patients Under Stress , Psychosom. Med. 11:25, 1949. 20. Malmo, R.; Shagass, C., and Davis, F. R.: Symptom Specificity and Bodily Reactions During Psychiatric Interview , Psychosom. Med. 12:362, 1950. 21. Malmo, R.; Shagass, C., and Davis, J. F.: Electromyographic Studies of Muscular Tension in Psychiatric Patients Under Stress , J. Clin. & Exper. Psychopath. 12:45, 1951. 22. McGinnies, E.: Emotionality and Perceptional Defense , Psychiat. Rev. 56:244, 1949. 23. Mead, S.; Mueller, E. E., and Harell, A.: Use of Intravenous Mephenesin (Tolserol) in Physical Medicine: Clinical and Laboratory Study , Brit. J. Phys. Med. 14:223, 1951. 24. Ruesch, J., and Finesinger, J. E.: Muscular Tension in Psychiatric Patients , Psychosom. Med. 5:132, 1943. 25. Schlan, L. S., and Unna, K. R.: Some Effects of Myanesin in Psychiatric Patients , J. A. M. A. 140:672, 1949. 26. Schlesinger, E. B.: Clinical Applications of Myanesin , Tr. New York Acad. Sc. 11:5, 1948. 27. Schlesinger, E. B.; Drew, L. A., and Wood, B.: Clinical Studies in Use of Myanesin , Am. J. Med. 4:365, 1948. 28. Spreng, R. W. E.: Tolserol in Acute Alcoholism , J. Nerv. & Ment. Dis. 118:545, 1953. 29. Stephen, C. R., and Chandy, J.: Clinical and Experimental Studies with Myanesin (Preliminary Report) , Canad. M. A. J. 57:463, 1947. 30. Thorndike, E. L., and Frage, J.: The Teachers' Word Book of 3,000 Words , New York, Columbia University Press, 1944. 31. Wolf, S., and Pinsky, R. H.: Effects of Placebo Administration and Occurrence of Toxic Reactions , J. A. M. A. 155:339, 1954.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Dec 1, 1955

References