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The Effect of Intravenous Demecolcine (Colcemid) on Acute Gout

The Effect of Intravenous Demecolcine (Colcemid) on Acute Gout Abstract In 1950 Šantavý and Reichstein 1 reported the isolation of several previously unknown alkaloids from the meadow saffron (Colchicum autumnale), the source of colchicine. Subsequently the pharmacological properties of these alkaloids were investigated by Schär, Loustalot, and Gross,2 and one of the compounds, demecolcine, was found to have an antimitotic effect equivalent to that of colchicine in fibroblast cultures and considerably less toxicity in laboratory animals. Structurally, demecolcine differs from colchicine in the replacement of the acetyl group at the nitrogen by a methyl radical (Fig.). Formulas of colchicine (left) and demecolcine (desacetylmethylcolcine) (right). Extensive laboratory study by Schär, Loustalot, and Gross demonstrated that, in all animal species, demecolcine is considerably less toxic than colchicine. In mice, for example, the intravenous lethal dose of demecolcine is as much as 40 times greater than that of colchicine. Paradoxically, in mice demecolcine is about six times more toxic orally than intravenously References 1. von Uffer, A.; Schindler, O.; Šantavý, F., and Reichstein, T.: Teilsynthese des Demecolcins und einiger anderer Colchicinderivate , Helvet. chim. acta 37:18, 1954.Crossref 2. Schär, B.; Loustalot, P., and Gross, F.: Demecolcin (Substanz F), ein neues, aus Colchicum autumnale isoliertes Alkaloid mit starker antimitotischer Wirkung , Klin. Wchnschr. 32:49-57, 1954.Crossref 3. Moeschlin, S.; Meyer, H., and Lichtman, A.: Ein neues Colchicumnebenalkaloid (Demecolcin Ciba) als Zytostatikum myeloischer Leukämien , Schweiz. med. Wchnschr. 83:990, 1953. 4. Leonard, B. J., and Wilkinson, J. F.: Desacetylmethylcolchicine in Treatment of Myeloid Leukaemia , Brit. M. J. 1:874, 1955.Crossref 5. Bock, H. E., and Gross, R.: Colchicinwirkungen und Granulocytopoese: Klinische und experimentelle Beobachtungen mit Substanz F aus Colchicum autumnale , Klin. Wchnschr. 31:816, 1953.Crossref 6. Davis, J. S., Jr., and Bartfeld, H.: Effect of Intravenous Colchicine on Acute Gout , Am. J. Med. 16:218, 1954.Crossref 7. Mugler, A.: Action de la colchicine sur les accidents allergiques , Ann. méd. 51:495, 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

The Effect of Intravenous Demecolcine (Colcemid) on Acute Gout

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1955.00250130027003
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1950 Šantavý and Reichstein 1 reported the isolation of several previously unknown alkaloids from the meadow saffron (Colchicum autumnale), the source of colchicine. Subsequently the pharmacological properties of these alkaloids were investigated by Schär, Loustalot, and Gross,2 and one of the compounds, demecolcine, was found to have an antimitotic effect equivalent to that of colchicine in fibroblast cultures and considerably less toxicity in laboratory animals. Structurally, demecolcine differs from colchicine in the replacement of the acetyl group at the nitrogen by a methyl radical (Fig.). Formulas of colchicine (left) and demecolcine (desacetylmethylcolcine) (right). Extensive laboratory study by Schär, Loustalot, and Gross demonstrated that, in all animal species, demecolcine is considerably less toxic than colchicine. In mice, for example, the intravenous lethal dose of demecolcine is as much as 40 times greater than that of colchicine. Paradoxically, in mice demecolcine is about six times more toxic orally than intravenously References 1. von Uffer, A.; Schindler, O.; Šantavý, F., and Reichstein, T.: Teilsynthese des Demecolcins und einiger anderer Colchicinderivate , Helvet. chim. acta 37:18, 1954.Crossref 2. Schär, B.; Loustalot, P., and Gross, F.: Demecolcin (Substanz F), ein neues, aus Colchicum autumnale isoliertes Alkaloid mit starker antimitotischer Wirkung , Klin. Wchnschr. 32:49-57, 1954.Crossref 3. Moeschlin, S.; Meyer, H., and Lichtman, A.: Ein neues Colchicumnebenalkaloid (Demecolcin Ciba) als Zytostatikum myeloischer Leukämien , Schweiz. med. Wchnschr. 83:990, 1953. 4. Leonard, B. J., and Wilkinson, J. F.: Desacetylmethylcolchicine in Treatment of Myeloid Leukaemia , Brit. M. J. 1:874, 1955.Crossref 5. Bock, H. E., and Gross, R.: Colchicinwirkungen und Granulocytopoese: Klinische und experimentelle Beobachtungen mit Substanz F aus Colchicum autumnale , Klin. Wchnschr. 31:816, 1953.Crossref 6. Davis, J. S., Jr., and Bartfeld, H.: Effect of Intravenous Colchicine on Acute Gout , Am. J. Med. 16:218, 1954.Crossref 7. Mugler, A.: Action de la colchicine sur les accidents allergiques , Ann. méd. 51:495, 1950.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1955

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