Abstract Objective: To validate a model for skin flap edema in the piglet and determine whether intraoperative and postoperative intradermal corticosteroids reduce the edema created. Design: Prospective, randomized, matched-control animal model. Setting: Animal laboratory. Participants: Twenty-five weight-matched purebred Yorkshire piglets. Intervention: Intraoperative and postoperative injections of intradermal triamcinolone. Main Outcomes Measured: Flap edema. Results: A reproducible skin flap edema model was validated in the piglet. Intraoperative intradermal corticosteroids decreased flap edema but postoperative corticosteroids did not. Conclusion: Clinical improvement in skin flap and supratip fullness may result from mechanisms other than edema.(Arch Otolaryngol Head Neck Surg. 1995;121:654-657) References 1. Fauci AS, Dale DC, Balow JE. Glucocorticosteroid therapy: mechanisms of action and clinical considerations . Ann Intern Med . 1976;84:304-315.Crossref 2. Marcus R, Coulston AM. Water-soluble vitamins: the vitamin B complex and ascorbic acid . In: Gilman AG, Rall TW, Nies AS, Taylor P, eds. Pharmacologic Basis of Therapeutics . Elmsford, NY: Pergamon Press Inc; 1990:1530-1552. 3. Hoffmann DF, Cook TA, Quatela VC, Wang TD, Brownrigg PJ, Brummett RE. Steroids in rhinoplasty . Arch Otolaryngol Head Neck Surg . 1991;117:990-993.Crossref 4. Griffies WS, Kennedy K, Gasser C, Fankhauser C, Taylor R. Steroids in rhinoplasty . Laryngoscope . 1989;99:1161-1164.Crossref 5. Simons RL. Steroids in rhinoplasty: a double-blind study . Arch Otolaryngol Head Neck Surg . 1991;117:994.Crossref 6. Cook TA, Hoffman DF. Rhinoplasty . Arch Otolaryngol Head Neck Surg . 1992; 118:1365.Crossref 7. Caci F, Gluck GM. Double-blind study of prednisolone and papase as inhibitors of complications after oral surgery . J Am Dent Assoc . 1976;93:325-327. 8. Huffman GG. Use of methylprednisolone sodium succinate to reduce postoperative edema after removal of impacted third molars . J Oral Surg . 1977;35: 198-199. 9. Schmidt JH. The efficacy of methylprednisolone in reducing flap edema . Plast Reconstr Surg . 1990;86:1148-1151.Crossref 10. Kerrigan CL. The pig as an experimental animal in plastic surgery research for the study of skin flap, myocutaneous flaps, and fasciocutaneous flaps . Lab Anim Sci . 1986;36:408-412. 11. Donovan WE. Experimental models in skin flap research . In: Grabb WC, Myers MB, eds. Skin Flaps . Boston, Mass: Little Brown & Co Inc; 1975:11-20. 12. Daniel RK, Williams HB. The free transfer of skin flaps by microvascular anastomoses: an experimental study and reappraisal, part 1: vascular supply of the skin . Plast Reconstr Surg . 1973;52:16-31.Crossref 13. Rasner B. Statistical methods in ophthalmology: an adjustment for the intraclass correlation between eyes . Biometrics . 1982;38:105-114.Crossref
Archives of Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Jun 1, 1995
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera