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The Effect of Intradermal Corticosteroids on Skin Flap Edema

The Effect of Intradermal Corticosteroids on Skin Flap Edema Abstract Objective: To validate a model for skin flap edema in the piglet and determine whether intraoperative and postoperative intradermal corticosteroids reduce the edema created. Design: Prospective, randomized, matched-control animal model. Setting: Animal laboratory. Participants: Twenty-five weight-matched purebred Yorkshire piglets. Intervention: Intraoperative and postoperative injections of intradermal triamcinolone. Main Outcomes Measured: Flap edema. Results: A reproducible skin flap edema model was validated in the piglet. Intraoperative intradermal corticosteroids decreased flap edema but postoperative corticosteroids did not. Conclusion: Clinical improvement in skin flap and supratip fullness may result from mechanisms other than edema.(Arch Otolaryngol Head Neck Surg. 1995;121:654-657) References 1. Fauci AS, Dale DC, Balow JE. Glucocorticosteroid therapy: mechanisms of action and clinical considerations . Ann Intern Med . 1976;84:304-315.Crossref 2. Marcus R, Coulston AM. Water-soluble vitamins: the vitamin B complex and ascorbic acid . In: Gilman AG, Rall TW, Nies AS, Taylor P, eds. Pharmacologic Basis of Therapeutics . Elmsford, NY: Pergamon Press Inc; 1990:1530-1552. 3. Hoffmann DF, Cook TA, Quatela VC, Wang TD, Brownrigg PJ, Brummett RE. Steroids in rhinoplasty . Arch Otolaryngol Head Neck Surg . 1991;117:990-993.Crossref 4. Griffies WS, Kennedy K, Gasser C, Fankhauser C, Taylor R. Steroids in rhinoplasty . Laryngoscope . 1989;99:1161-1164.Crossref 5. Simons RL. Steroids in rhinoplasty: a double-blind study . Arch Otolaryngol Head Neck Surg . 1991;117:994.Crossref 6. Cook TA, Hoffman DF. Rhinoplasty . Arch Otolaryngol Head Neck Surg . 1992; 118:1365.Crossref 7. Caci F, Gluck GM. Double-blind study of prednisolone and papase as inhibitors of complications after oral surgery . J Am Dent Assoc . 1976;93:325-327. 8. Huffman GG. Use of methylprednisolone sodium succinate to reduce postoperative edema after removal of impacted third molars . J Oral Surg . 1977;35: 198-199. 9. Schmidt JH. The efficacy of methylprednisolone in reducing flap edema . Plast Reconstr Surg . 1990;86:1148-1151.Crossref 10. Kerrigan CL. The pig as an experimental animal in plastic surgery research for the study of skin flap, myocutaneous flaps, and fasciocutaneous flaps . Lab Anim Sci . 1986;36:408-412. 11. Donovan WE. Experimental models in skin flap research . In: Grabb WC, Myers MB, eds. Skin Flaps . Boston, Mass: Little Brown & Co Inc; 1975:11-20. 12. Daniel RK, Williams HB. The free transfer of skin flaps by microvascular anastomoses: an experimental study and reappraisal, part 1: vascular supply of the skin . Plast Reconstr Surg . 1973;52:16-31.Crossref 13. Rasner B. Statistical methods in ophthalmology: an adjustment for the intraclass correlation between eyes . Biometrics . 1982;38:105-114.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

The Effect of Intradermal Corticosteroids on Skin Flap Edema

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1995.01890060052010
Publisher site
See Article on Publisher Site

Abstract

Abstract Objective: To validate a model for skin flap edema in the piglet and determine whether intraoperative and postoperative intradermal corticosteroids reduce the edema created. Design: Prospective, randomized, matched-control animal model. Setting: Animal laboratory. Participants: Twenty-five weight-matched purebred Yorkshire piglets. Intervention: Intraoperative and postoperative injections of intradermal triamcinolone. Main Outcomes Measured: Flap edema. Results: A reproducible skin flap edema model was validated in the piglet. Intraoperative intradermal corticosteroids decreased flap edema but postoperative corticosteroids did not. Conclusion: Clinical improvement in skin flap and supratip fullness may result from mechanisms other than edema.(Arch Otolaryngol Head Neck Surg. 1995;121:654-657) References 1. Fauci AS, Dale DC, Balow JE. Glucocorticosteroid therapy: mechanisms of action and clinical considerations . Ann Intern Med . 1976;84:304-315.Crossref 2. Marcus R, Coulston AM. Water-soluble vitamins: the vitamin B complex and ascorbic acid . In: Gilman AG, Rall TW, Nies AS, Taylor P, eds. Pharmacologic Basis of Therapeutics . Elmsford, NY: Pergamon Press Inc; 1990:1530-1552. 3. Hoffmann DF, Cook TA, Quatela VC, Wang TD, Brownrigg PJ, Brummett RE. Steroids in rhinoplasty . Arch Otolaryngol Head Neck Surg . 1991;117:990-993.Crossref 4. Griffies WS, Kennedy K, Gasser C, Fankhauser C, Taylor R. Steroids in rhinoplasty . Laryngoscope . 1989;99:1161-1164.Crossref 5. Simons RL. Steroids in rhinoplasty: a double-blind study . Arch Otolaryngol Head Neck Surg . 1991;117:994.Crossref 6. Cook TA, Hoffman DF. Rhinoplasty . Arch Otolaryngol Head Neck Surg . 1992; 118:1365.Crossref 7. Caci F, Gluck GM. Double-blind study of prednisolone and papase as inhibitors of complications after oral surgery . J Am Dent Assoc . 1976;93:325-327. 8. Huffman GG. Use of methylprednisolone sodium succinate to reduce postoperative edema after removal of impacted third molars . J Oral Surg . 1977;35: 198-199. 9. Schmidt JH. The efficacy of methylprednisolone in reducing flap edema . Plast Reconstr Surg . 1990;86:1148-1151.Crossref 10. Kerrigan CL. The pig as an experimental animal in plastic surgery research for the study of skin flap, myocutaneous flaps, and fasciocutaneous flaps . Lab Anim Sci . 1986;36:408-412. 11. Donovan WE. Experimental models in skin flap research . In: Grabb WC, Myers MB, eds. Skin Flaps . Boston, Mass: Little Brown & Co Inc; 1975:11-20. 12. Daniel RK, Williams HB. The free transfer of skin flaps by microvascular anastomoses: an experimental study and reappraisal, part 1: vascular supply of the skin . Plast Reconstr Surg . 1973;52:16-31.Crossref 13. Rasner B. Statistical methods in ophthalmology: an adjustment for the intraclass correlation between eyes . Biometrics . 1982;38:105-114.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Jun 1, 1995

References

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