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The Effect of Hydrocortisone on the Healing of Wounds of the Brain: An Experimental Study on the Cat

The Effect of Hydrocortisone on the Healing of Wounds of the Brain: An Experimental Study on the Cat Abstract The literature concerning the effects of the adrenal steroids cortisone and hydrocortisone on tissues and systems is exhaustive. Hydrocortisone U. S. P. (17-hydroxycorticosterone; Compound F) has been reported to be more potent, milligram by milligram, than cortisone,1 and the main physiologic actions of the two are similar.2 Hydrocortisone used in local application allows a higher concentration of the hormone in the tissue, and the difference in local effectiveness as compared with that of cortisone remains unexplained.3 Wound healing is delayed by cortisone,* and several tissues have been reported to be affected in the healing process when the adrenocortical steroid is given in high doses parenterally,7 by local application, by subcutaneous injection,8 or subconjunctivally.† The action of cortisone in the healing of the central nervous system as noted experimentally has been observed to be a depression of the early inflammatory phase in puncture wounds of the References 1. References 4 to 6. 2. References 9 and 10. 3. Beltran, G. P.: La Intervención del acetato de cortisona en los procesos cicatriciales post-traumaticos del sistema nervioso , Thesis, Universidad Nacional Autonoma de Mexico, Facultad de Medicina, 1953. 4. Gibson, R. N.: The Effect of Cortisone in the Healing of Incised Cerebral Wounds , Thesis, McGill University, 1951. 5. The hydrocortisone acetate was supplied by Merck & Co., Ltd., Montreal, Canada, in saline suspension of Hydrocortone acetate and as hydrocortisone acetate powder. 6. References 14 and 15. 7. References 16 and 17. 8. References 19 and 20. 9. Ingle, D. J.; Nezamis, J. E., and Morley, E. H.: Work Performance of Adrenalectomized Rats Given Cortisone and 17-Hydroxycorticosterone by Continuous Intravenous Injection , Proc. Soc. Exper. Biol. & Med. 78:79-81, 1951. 10. Perera, G. A.; Ragan, C., and Werner, S. C.: Clinical and Metabolic Study of 17-Hydroxycorticosterone (Kendall Compound F): Comparison with Cortisone , Proc. Soc. Exper. Biol. & Med. 77:326-330, 1951. 11. Thorn, W. G., and others: Pharmacological Aspects of Adrenocortical Steroids and ACTH in Man , New England J. Med. 248:414-422, 1953. 12. Howes, E. L.; Plotz, C. M.; Blunt, J. W., and Ragan, C.: Retardation of Wound Healing by Cortisone , Surgery 28:177-181, 1950. 13. Blunt, J. W., Jr.; Plotz, C. M.; Lattes, R.; Howes, E. L.; Meyer, K., and Ragan, C.: Effect of Cortisone on Experimental Fractures in Rabbit , Proc. Soc. Exper. Biol. & Med. 73:678-681, 1950. 14. Ragan, C.; Howes, E. L.; Plotz, C. M.; Meyer, K., and Blunt, J. W.: Effect of Cortisone in the Production of Granulation Tissue on Rabbit , Proc. Soc. Exper. Biol. & Med. 72:718-721, 1949. 15. Wrenn, R. N.; Goldner, J. L., and Markle, J. L.: An Experimental Study of the Effect of Cortisone on the Healing Process and Tensile Strength of Tendons , J. Bone & Joint Surg. 36-A: 588-601, 1954. 16. Baker, L.; Wayne, W. L., and Whitaker, L.: Interference with Wound Healing by the Local Action of Adrenocortical Steroids , Endocrinology 46:544-551, 1950. 17. Ashton, N., and Cook, C.: Effects of Cortisone on the Healing of Corneal Wounds , Brit. J. Ophth. 35:708-717, 1951. 18. Newell, F. W., and Dixon, J. M.: Effect of Subconjunctival Cortisone upon the Immediate Union of Experimental Corneal Grafts , Am. J. Ophth. 34:977-982, 1951. 19. Foley, J. M.; Chambers, R. A., and Adams, R. D.: The Effect of Cortisone on the Early Repair of Brain Wounds in Guinea Pigs , J. Neuropath. & Exper. Neurol. 12:101-104, 1953. 20. Caso, A.: Effectos del tratamiento de las lesiones cerebrales con ACTH , Bol. Inst. estud. med. y biol. 11:61-74, 1953. 21. Oppenheimer, J. H., and Riester, W. H.: Influence of Cortisone on Leptomeningeal Reaction Induced by Talc , Proc. Soc. Exper. Biol. & Med. 83:844-847, 1953. 22. Baron, D. N., and Abelson, D.: Cortisone and Hydrocortisone in Cerebrospinal Fluid , Nature, London , 173:174, 1954. 23. Macek, T. H.; Baade, W. H.; Bornn, A., and Bacher, F. A.: Observations on the Solubility of Some Cortical Hormones , Science 116:399, 1952. 24. Spain, D. M.; Molomut, N., and Haber, A.: Biological Studies of Cortisone in Mice , Science 112:335-337, 1950. 25. Gordon, A. S., and Katsch, G. F.: Relation of Adrenal Cortex to Structure and Phagocytic Activity of Macrophagic System , Ann. New York Acad. Sc. 52:1-30, 1949. 26. Ramón y Cajal, S.: Degeneration and Regeneration of the Nervous System , London, Oxford University Press, 1928, Vol. 2, pp. 727-733. 27. Grossfeld, H., and Ragan, C.: Action of Hydrocortisone on Cells in Tissue Culture , Proc. Soc. Exper. Biol. & Med. 86:63-68, 1954. 28. Castor, W. C., and Baker, B. L.: Local Action of Adrenocortical Steroids on Epidermis and Connective Tissue of the Skin , Endocrinology 47: 234-241, 1950. 29. Bush, I. E.: Species Differences and Other Factors Influencing Adrenocortical Secretion, Ciba Foundation Colloquia on Endocrinology , Boston, Little, Brown & Company, 1953, Vol. 7, pp. 210-232. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

The Effect of Hydrocortisone on the Healing of Wounds of the Brain: An Experimental Study on the Cat

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330160057008
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Abstract

Abstract The literature concerning the effects of the adrenal steroids cortisone and hydrocortisone on tissues and systems is exhaustive. Hydrocortisone U. S. P. (17-hydroxycorticosterone; Compound F) has been reported to be more potent, milligram by milligram, than cortisone,1 and the main physiologic actions of the two are similar.2 Hydrocortisone used in local application allows a higher concentration of the hormone in the tissue, and the difference in local effectiveness as compared with that of cortisone remains unexplained.3 Wound healing is delayed by cortisone,* and several tissues have been reported to be affected in the healing process when the adrenocortical steroid is given in high doses parenterally,7 by local application, by subcutaneous injection,8 or subconjunctivally.† The action of cortisone in the healing of the central nervous system as noted experimentally has been observed to be a depression of the early inflammatory phase in puncture wounds of the References 1. References 4 to 6. 2. References 9 and 10. 3. Beltran, G. P.: La Intervención del acetato de cortisona en los procesos cicatriciales post-traumaticos del sistema nervioso , Thesis, Universidad Nacional Autonoma de Mexico, Facultad de Medicina, 1953. 4. Gibson, R. N.: The Effect of Cortisone in the Healing of Incised Cerebral Wounds , Thesis, McGill University, 1951. 5. The hydrocortisone acetate was supplied by Merck & Co., Ltd., Montreal, Canada, in saline suspension of Hydrocortone acetate and as hydrocortisone acetate powder. 6. References 14 and 15. 7. References 16 and 17. 8. References 19 and 20. 9. Ingle, D. J.; Nezamis, J. E., and Morley, E. H.: Work Performance of Adrenalectomized Rats Given Cortisone and 17-Hydroxycorticosterone by Continuous Intravenous Injection , Proc. Soc. Exper. Biol. & Med. 78:79-81, 1951. 10. Perera, G. A.; Ragan, C., and Werner, S. C.: Clinical and Metabolic Study of 17-Hydroxycorticosterone (Kendall Compound F): Comparison with Cortisone , Proc. Soc. Exper. Biol. & Med. 77:326-330, 1951. 11. Thorn, W. G., and others: Pharmacological Aspects of Adrenocortical Steroids and ACTH in Man , New England J. Med. 248:414-422, 1953. 12. Howes, E. L.; Plotz, C. M.; Blunt, J. W., and Ragan, C.: Retardation of Wound Healing by Cortisone , Surgery 28:177-181, 1950. 13. Blunt, J. W., Jr.; Plotz, C. M.; Lattes, R.; Howes, E. L.; Meyer, K., and Ragan, C.: Effect of Cortisone on Experimental Fractures in Rabbit , Proc. Soc. Exper. Biol. & Med. 73:678-681, 1950. 14. Ragan, C.; Howes, E. L.; Plotz, C. M.; Meyer, K., and Blunt, J. W.: Effect of Cortisone in the Production of Granulation Tissue on Rabbit , Proc. Soc. Exper. Biol. & Med. 72:718-721, 1949. 15. Wrenn, R. N.; Goldner, J. L., and Markle, J. L.: An Experimental Study of the Effect of Cortisone on the Healing Process and Tensile Strength of Tendons , J. Bone & Joint Surg. 36-A: 588-601, 1954. 16. Baker, L.; Wayne, W. L., and Whitaker, L.: Interference with Wound Healing by the Local Action of Adrenocortical Steroids , Endocrinology 46:544-551, 1950. 17. Ashton, N., and Cook, C.: Effects of Cortisone on the Healing of Corneal Wounds , Brit. J. Ophth. 35:708-717, 1951. 18. Newell, F. W., and Dixon, J. M.: Effect of Subconjunctival Cortisone upon the Immediate Union of Experimental Corneal Grafts , Am. J. Ophth. 34:977-982, 1951. 19. Foley, J. M.; Chambers, R. A., and Adams, R. D.: The Effect of Cortisone on the Early Repair of Brain Wounds in Guinea Pigs , J. Neuropath. & Exper. Neurol. 12:101-104, 1953. 20. Caso, A.: Effectos del tratamiento de las lesiones cerebrales con ACTH , Bol. Inst. estud. med. y biol. 11:61-74, 1953. 21. Oppenheimer, J. H., and Riester, W. H.: Influence of Cortisone on Leptomeningeal Reaction Induced by Talc , Proc. Soc. Exper. Biol. & Med. 83:844-847, 1953. 22. Baron, D. N., and Abelson, D.: Cortisone and Hydrocortisone in Cerebrospinal Fluid , Nature, London , 173:174, 1954. 23. Macek, T. H.; Baade, W. H.; Bornn, A., and Bacher, F. A.: Observations on the Solubility of Some Cortical Hormones , Science 116:399, 1952. 24. Spain, D. M.; Molomut, N., and Haber, A.: Biological Studies of Cortisone in Mice , Science 112:335-337, 1950. 25. Gordon, A. S., and Katsch, G. F.: Relation of Adrenal Cortex to Structure and Phagocytic Activity of Macrophagic System , Ann. New York Acad. Sc. 52:1-30, 1949. 26. Ramón y Cajal, S.: Degeneration and Regeneration of the Nervous System , London, Oxford University Press, 1928, Vol. 2, pp. 727-733. 27. Grossfeld, H., and Ragan, C.: Action of Hydrocortisone on Cells in Tissue Culture , Proc. Soc. Exper. Biol. & Med. 86:63-68, 1954. 28. Castor, W. C., and Baker, B. L.: Local Action of Adrenocortical Steroids on Epidermis and Connective Tissue of the Skin , Endocrinology 47: 234-241, 1950. 29. Bush, I. E.: Species Differences and Other Factors Influencing Adrenocortical Secretion, Ciba Foundation Colloquia on Endocrinology , Boston, Little, Brown & Company, 1953, Vol. 7, pp. 210-232.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Oct 1, 1955

References