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The Effect of Dimethyl Sulfoxide (DMSO) on Animal and Human Eyes

The Effect of Dimethyl Sulfoxide (DMSO) on Animal and Human Eyes Abstract Based on animal results and as regards shortterm administration of dimethyl sulfoxide (DMSO) clinically, repetitious and detailed ophthalmoscopic rechecking of patients seems unnecessary. However, when long-term administration is contemplated, exacting pretreatment study is necessary in order that lenticular abnormalities or other pathologic ocular conditions already present may be identified and quantitated. Only with such base-line information can the possible undesired effects of medication be objectively followed. if any single fact has emerged from animal and human studies with DMSO to date, it is that the lens toxicity findings originally reported in dogs and later confirmed in certain other species have no equivalent or counterpart in human therapy utilizing DMSO in generally accepted regimens. References 1. Beckloff, G.L.; Oliver, P.M.; and Demos, D.H.: Dimethyl Sulfoxide in Musculoskeletal Disorders , Ann NY Acad Sci 141:517, 1967.Crossref 2. Rubin, L., and Barnett, K.C.: Ocular Effects of Oral and Dermal Applications of Dimethyl Sulfoxide in Animals , Ann NY Acad Sci 141:333, 1967.Crossref 3. Rubin, L., and Mattis, P.A.: Dimethyl Sulfoxide: Lens Changes in Dogs During Oral Administration , Science 153:83-84, 1966.Crossref 4. Kleberger, K.E.: " Zur Toxikologie des DMSO am Auge ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 56. 5. Kleberger, K.E.: An Ophthalmological Evaluation of DMSO , Ann NY Acad Sci 141:381, 1967.Crossref 6. Wood, D.C., et al: A Study of DMSO and Corticosteroids in Rabbit Eyes , Ann NY Acad Sci 141:346, 1967.Crossref 7. Jacob, S.W., and Rosenbaum, E.E.: The Toxicology of Dimethyl Sulfoxide (DMSO) , Headache 6:127, 1966.Crossref 8. Wood, D.C., and Wirth, N.B.: " Further Studies on the Effect of Dimethyl Sulfoxide on the Eyes in Rabbits ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 58. 9. Esilä, R., and Tenhunen, T.: Dimethyl Sulfoxide: Lens Changes, Composition of the Anterior Aqueous Humour and Intraocular Pressure in Rabbits During Oral Administration , Acta Ophthal 14:530, 1967. 10. Barnett, K.C., and Noel, P.R.B.: Dimethyl Sulphoxide and Lens Changes in Primates , Nature 214:1115 ( (June 10) ) 1967.Crossref 11. Kutschera, E.: " Ergebnisse von Augenuntersuchungen bei lengerdauernder DMSO-Therapie ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 177. 12. Gordon, D.: DMSO in Ophthalmology—With Special Reference to Possible Influences Upon Refraction , Ann NY Acad Sci 141:392, 1967.Crossref 13. Gordon, D.: " Dimethyl Sulfoxyd in der Ophthalmologischen Praxis ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 179. 14. Scherbel, A.: " Use of DMSO for the Treatment of Scleroderma ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966. 15. Laudahn, G., and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966. 16. Kolb, K.H., et al: Absorption, Distribution and Elimination of Labelled Dimethyl Sulfoxide in Man and Animals , Ann NY Acad Sci 141:85, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Effect of Dimethyl Sulfoxide (DMSO) on Animal and Human Eyes

Archives of Ophthalmology , Volume 79 (4) – Apr 1, 1968

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1968.03850040425011
Publisher site
See Article on Publisher Site

Abstract

Abstract Based on animal results and as regards shortterm administration of dimethyl sulfoxide (DMSO) clinically, repetitious and detailed ophthalmoscopic rechecking of patients seems unnecessary. However, when long-term administration is contemplated, exacting pretreatment study is necessary in order that lenticular abnormalities or other pathologic ocular conditions already present may be identified and quantitated. Only with such base-line information can the possible undesired effects of medication be objectively followed. if any single fact has emerged from animal and human studies with DMSO to date, it is that the lens toxicity findings originally reported in dogs and later confirmed in certain other species have no equivalent or counterpart in human therapy utilizing DMSO in generally accepted regimens. References 1. Beckloff, G.L.; Oliver, P.M.; and Demos, D.H.: Dimethyl Sulfoxide in Musculoskeletal Disorders , Ann NY Acad Sci 141:517, 1967.Crossref 2. Rubin, L., and Barnett, K.C.: Ocular Effects of Oral and Dermal Applications of Dimethyl Sulfoxide in Animals , Ann NY Acad Sci 141:333, 1967.Crossref 3. Rubin, L., and Mattis, P.A.: Dimethyl Sulfoxide: Lens Changes in Dogs During Oral Administration , Science 153:83-84, 1966.Crossref 4. Kleberger, K.E.: " Zur Toxikologie des DMSO am Auge ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 56. 5. Kleberger, K.E.: An Ophthalmological Evaluation of DMSO , Ann NY Acad Sci 141:381, 1967.Crossref 6. Wood, D.C., et al: A Study of DMSO and Corticosteroids in Rabbit Eyes , Ann NY Acad Sci 141:346, 1967.Crossref 7. Jacob, S.W., and Rosenbaum, E.E.: The Toxicology of Dimethyl Sulfoxide (DMSO) , Headache 6:127, 1966.Crossref 8. Wood, D.C., and Wirth, N.B.: " Further Studies on the Effect of Dimethyl Sulfoxide on the Eyes in Rabbits ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 58. 9. Esilä, R., and Tenhunen, T.: Dimethyl Sulfoxide: Lens Changes, Composition of the Anterior Aqueous Humour and Intraocular Pressure in Rabbits During Oral Administration , Acta Ophthal 14:530, 1967. 10. Barnett, K.C., and Noel, P.R.B.: Dimethyl Sulphoxide and Lens Changes in Primates , Nature 214:1115 ( (June 10) ) 1967.Crossref 11. Kutschera, E.: " Ergebnisse von Augenuntersuchungen bei lengerdauernder DMSO-Therapie ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 177. 12. Gordon, D.: DMSO in Ophthalmology—With Special Reference to Possible Influences Upon Refraction , Ann NY Acad Sci 141:392, 1967.Crossref 13. Gordon, D.: " Dimethyl Sulfoxyd in der Ophthalmologischen Praxis ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966, p 179. 14. Scherbel, A.: " Use of DMSO for the Treatment of Scleroderma ," in Laudahn, G. and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966. 15. Laudahn, G., and Gertich, K. (eds.): Dimethyl-Sulfoxyd Internationale Symposium am 8/9 November 1966 , Berlin: Saladruck, 1966. 16. Kolb, K.H., et al: Absorption, Distribution and Elimination of Labelled Dimethyl Sulfoxide in Man and Animals , Ann NY Acad Sci 141:85, 1967.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1968

References